Delayed cortical development in mice with a neural specific deletion of β1 integrin [PDF]
Frontiers in Neuroscience, 2023 The adhesion systems employed by migrating cortical neurons are not well understood. Genetic deletion studies of focal adhesion kinase (FAK) and paxillin in mice suggested that these classical focal adhesion molecules control the morphology and speed of ...
Mamunur Rashid +2 more
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Regulation of Renin Expression by Β1-Integrin in As4.1 Juxtaglomerular Line Cells [PDF]
Biomedicines, 2023 (1) Background: Renal dysfunction and hypertension are mutually aggravating factors; however, the details of their interaction remain unclear. In a study using renal tissue from diabetic rats, we found that β1-integrin, a cell-substrate adhesion molecule,
Nobumichi Saito +7 more
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New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain [PDF]
Life Science Alliance, 2022 This study investigates phosphorylation of and kindlin recruitment by the double-threonine motif in the β1 integrin cytoplasmic tails. Integrins require an activation step before ligand binding and signaling that is mediated by talin and kindlin binding ...
Ralph T Böttcher +3 more
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Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice [PDF]
Journal of Orthopaedic Translation, 2022 Background: The key focal adhesion protein β1 integrin plays an essential role in early skeletal development. However, roles of β1 integrin expression in osteocytes during the regulation of bone homeostasis and mechanotransduction are incompletely ...
Lei Qin +14 more
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Calreticulin Regulates β1-Integrin mRNA Stability in PC-3 Prostate Cancer Cells [PDF]
Biomedicines, 2022 Prostate cancer (PCa) is the major cause of cancer-related death among aging men worldwide. Recent studies have suggested that calreticulin (CRT), a multifunctional chaperon protein, may play an important role in the regulation of PCa tumorigenesis and ...
Yueh-Chien Lin +6 more
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Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling [PDF]
The Journal of Clinical InvestigationThe blood and lymphatic vascular systems are regulated by angiopoietin (ANGPT) growth factors, which signal via endothelial TIE receptor tyrosine kinases and integrins. However, mechanistic understanding of how these receptors crosstalk is limited. Here,
Tuomas Sipilä +15 more
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TIMP1 protects against blood-brain barrier disruption after subarachnoid haemorrhage by inhibiting ubiquitination of astrocytic β1-integrin [PDF]
Stroke and Vascular NeurologyBackground Astrocytes regulate blood-brain barrier (BBB) integrity, whereas subarachnoid haemorrhage (SAH) results in astrocyte dysregulation and BBB disruption. Here, we explored the involvement of tissue inhibitor of matrix metalloprotease-1 (TIMP1) in
Jing Liu +18 more
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β1 integrin is essential for blood–brain barrier integrity under stable and vascular remodelling conditions; effects differ with age [PDF]
Fluids and Barriers of the CNS, 2023 Background Maintaining a tight blood–brain barrier (BBB) is an important prerequisite for the preservation of neurological health, though current evidence suggests it declines with age. While extracellular matrix-integrin interactions play critical roles
Sebok K. Halder +2 more
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Analysis of the expression and prognostic value of MT1-MMP, β1-integrin and YAP1 in glioma [PDF]
Open Medicine, 2022 Increased expression of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) is associated with the development of many cancers. MT1-MMP may promote the entry of yes-associated protein1 (YAP1) into the nucleus by regulating the regulation of β1 ...
Zhai Yangyang +5 more
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β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny. [PDF]
PLoS ONE, 2013 β1 integrin regulates multiple epithelial cell functions by connecting cells with the extracellular matrix (ECM). While β1 integrin-mediated signaling in murine epithelial stem cells is well-studied, its role in human adult epithelial progenitor cells ...
Nancy Ernst +6 more
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