The primacy of β1 integrin activation in the metastatic cascade. [PDF]
PLoS ONE, 2012 After neoplastic cells leave the primary tumor and circulate, they may extravasate from the vasculature and colonize tissues to form metastases. β1 integrins play diverse roles in tumorigenesis and tumor progression, including extravasation.
Hisashi Kato +7 more
doaj +2 more sources
β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells.
PLoS ONE, 2014 Astrogliosis with glial scar formation after damage to the nervous system is a major impediment to axonal regeneration and functional recovery. The present study examined the role of β1-integrin signaling in regulating astrocytic differentiation of ...
Liuliu Pan +7 more
doaj +2 more sources
Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer
Cancer Cell International, 2018 Background Integrins play a critical role in carcinogenesis. Integrin β1 localization is regulated by the guanosine-5′-triphosphate hydrolase Rab25 and integrin β1 levels are elevated in the serum of colon cancer patients; thus, the present study ...
Kyung Sook Hong +4 more
doaj +2 more sources
The linkage between β1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of β1 integrin in normal and cancerous human breast cells [PDF]
BMC Cell Biology, 2001 Background Structural requirements for the β1 integrin functions in cell adhesion, spreading and signaling have been well documented mainly for fibroblasts.
Takahashi Kazuhide
doaj +2 more sources
Integrin β1, Osmosensing, and Chemoresistance in Mouse Ehrlich Carcinoma Cells
Cellular Physiology and Biochemistry, 2015 Background/Aims: Altered expression of the integrin family of cell adhesion receptors has been associated with initiation, progression, and metastasis of solid tumors as well as in the development of chemoresistance.
Belinda Halling Sørensen +7 more
doaj +2 more sources
Integrin β1 activation induces an anti-melanoma host response. [PDF]
PLoS ONE, 2017 TGF-β is a cytokine thought to function as a tumor promoter in advanced malignancies. In this setting, TGF-β increases cancer cell proliferation, survival, and migration, and orchestrates complex, pro-tumorigenic changes in the tumor microenvironment ...
Laila Ritsma +7 more
doaj +2 more sources
Effective treatment of HER2-amplified breast cancer by targeting HER3 and β1 integrin [PDF]
Breast Cancer Research and Treatment, 2016 The central role of HER2 as the disease driver and HER3 as its essential partner has made them rational targets for the treatment of HER2-amplifed breast cancers, and there is considerable interest in developing highly effective treatment regimens for this disease that consist of targeted therapies alone.
Campbell, Marcia R +9 more
openaire +4 more sources
Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles [PDF]
Journal of Cell Biology, 2019 ABSTRACT Receptor tyrosine kinases (RTKs) are important cargo in endocytic trafficking, yet their role in endosomal sorting and maturation of multivesicular bodies (MVBs) remains unclear. Here we show that the ErbB3 receptor sorts internalised Integrin β1, and the transferrin receptor (TfR), for endocytic recycling, in a manner that ...
Dorival Mendes Rodrigues-Junior +7 more
openaire +4 more sources
Role of β1 integrin in thrombocytopoiesis. [PDF]
Fac Rev, 2021 : Thrombocytopoiesis is a complex process beginning at the level of hematopoietic stem cells, which ultimately generate megakaryocytes, large marrow cells with a distinctive morphology, and then, through a process of terminal maturation, megakaryocytes ...
Mazzarini M +3 more
europepmc +2 more sources
Frontiers in Cell and Developmental Biology, 2022 β1-integrin is a key receptor that regulates cell-ECM interactions and is important in maintaining mature beta-cell functions, including insulin secretion.
Malina Barillaro +5 more
doaj +1 more source