Results 31 to 40 of about 145,582 (253)

Integrin β1 regulates the invasion and radioresistance of laryngeal cancer cells by targeting CD147

Cancer Cell International, 2018
Background Increased expression of integrin β1 has been reported to correlate with progression and therapy resistance in many types of cancers. The aim of this study was to investigate the effects of integrin β1 on the invasion and radioresistance of ...
Li Li, Xiaoxia Dong, Feng Peng, Li Shen
doaj   +1 more source

Integrin β1 is a key determinant of the expression of angiotensin-converting enzyme 2 (ACE2) in the kidney epithelial cells.

European Journal of Cell Biology, 2023
The expression of the angiotensin-converting enzyme 2 (ACE2) is altered in multiple chronic kidney diseases like hypertension and renal fibrosis, where the signaling from the basal membrane proteins is critical for the development and progression of the ...
Md Saimon Mia, Delowar Hossain, Emerson Woodbury, Sean Kelleher, Riya.J. Palamuttam, Reena Rao, Preston Steen, Yagna PR Jarajapu, Sijo Mathew   +8 more
doaj   +1 more source

The role of NCAM signaling and its effector protein, [beta]1-integrin, in tumor progression [PDF]

, 2007
Neural Cell Adhesion Molecule (NCAM) is a member of the large family of Ca2+independent, immunoglobulin (Ig)-like cell adhesion molecules. So far, its function in homophilic and heterophilic interactions has been mainly studied in neuronal cells, where ...
Kren, Angelika
core   +1 more source

Galectin-3 induces clustering of CD147 and integrin-β1 transmembrane glycoprotein receptors on the RPE cell surface. [PDF]

PLoS ONE, 2013
Proliferative vitreoretinopathy (PVR) is a blinding disease frequently occurring after retinal detachment surgery. Adhesion, migration and matrix remodeling of dedifferentiated retinal pigment epithelial (RPE) cells characterize the onset of the disease.
Claudia S Priglinger, Christoph M Szober, Siegfried G Priglinger, Juliane Merl, Kerstin N Euler, Marcus Kernt, Gabor Gondi, Jennifer Behler, Arie Geerlof, Anselm Kampik, Marius Ueffing, Stefanie M Hauck   +11 more
doaj   +1 more source

Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress

Cellular Physiology and Biochemistry, 2015
Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities ...
Wenwei Liang, Chunhui Zhu, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Qijia Zhou, Shun Xu, Chenjun Zhai, Weimin Fan   +9 more
doaj   +1 more source

Regulation of opticin on bioactivity of retinal vascular endothelial cells cultured in collagen [PDF]

International Journal of Ophthalmology, 2020
AIM: To investigate the effects of collagen and opticin on the bioactivity of human retinal vascular endothelial cells (hRVECs), and explore its regulations by integrins and RhoA/ROCK1 signal pathway.
Yue Xing, Xue-Ke Li, Si-Duo Lu, Jin Ma
doaj   +1 more source

MOESM1 of Lipid-rafts remain stable even after ionizing radiation induced disintegration of β1 integrin containing focal adhesions

, 2017
Additional file 1. Additional information. Details of experimental procedure and Additional figures S1, S2 and S3.
Babel, Laura, Kruse, Larissa, Bump, Steven, Langhans, Markus, Meckel, Tobias   +4 more
openaire   +1 more source

Integrin β1 Is Required for Dermal Homeostasis [PDF]

, 2013
Integrins are heterodimers that mediate cell attachment to the extracellular matrix. Previously, we used fibroblast-specific knockout mice to show that the integrin β1 subunit was required in vivo for dermal fibrogenesis and cutaneous tissue repair. Here,
Liu, Shangxi, Andrew Leask, Shangxi Liu, Leask, Andrew   +3 more
core   +1 more source

Ligand-independent integrin β1 signaling supports lung adenocarcinoma development

JCI Insight, 2022
Integrins — the principal extracellular matrix (ECM) receptors of the cell — promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis.
Scott M. Haake, Erin J. Plosa, Jonathan A. Kropski, Lindsay A. Venton, Anupama Reddy, Fabian Bock, Betty T. Chang, Allen J. Luna, Kateryna Nabukhotna, Zhi-Qi Xu, Rebecca A. Prather, Sharon Lee, Harikrishna Tanjore, Vasiliy V. Polosukhin, Olga M. Viquez, Angela Jones, Wentian Luo, Matthew H. Wilson, W. Kimryn Rathmell, Pierre P. Massion, Ambra Pozzi, Timothy S. Blackwell, Roy Zent   +22 more
doaj   +1 more source

Additional file 1: of The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration

, 2019
Figure S1. Small vesicles containing CD93 colocalize with caveolin-1 in early spreading ECs. Figure S2. Disruption of the actin cytoskeleton impairs CD93 intracellular trafficking. Figure S3. Microtubule cytoskeleton disruption has no effects on CD93 intracellular trafficking. Figure S4.
Barbera, Stefano, Nardi, Federica, Elia, Ines, Realini, Giulia, Lugano, Roberta, Santucci, Annalisa, Tosi, Gian, Dimberg, Anna, Galvagni, Federico, Orlandini, Maurizio   +9 more
openaire   +1 more source