The characteristics and the multiple functions of integrin β1 in human cancers
Journal of Translational Medicine, 2023 Integrins, which consist of two non-covalently linked α and β subunits, play a crucial role in cell–cell adhesion and cell-extracellular matrix (ECM) interactions.
Li Sun +3 more
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Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1
Cell Communication and Signaling, 2019 Background Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits. Methods Here we employed biochemical
Juan Gao +12 more
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Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair [PDF]
, 2012 The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment.
Susan McIntyre +13 more
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Decreased integrin β1 in lipid raft inhibits proliferation and migration of HPS rat serum-induced PMVECs [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate the effects of integrin β1 within lipid raft on PMVECs. Methods PMVECs were divided into four groups: control group; HPS group: HPS; group and MβCD group: the cells were pretreated with 0.01 mol/L MβCD for 1 hour, and
GAO Jing, ZHOU Jia-qi
doaj
Oncotarget, 2018 // Zhongyu Zhang 1 , Yuan Guan 1 , Xiyao Yu 1 , Hairong Cheng 1 , Yifa Zhou 1 and Guihua Tai 1 1 School of Life Sciences, Northeast Normal University, Changchun, PR China Correspondence to: Guihua Tai, email: taigh477@nenu.edu.cn Keywords : galectin-3; CRD; migration; HMEC-1; β1 integrin Received: August 18, 2017 Accepted ...
Zhongyu Zhang +11 more
openaire +1 more source
ß1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli [PDF]
, 2005 Integrins are cell adhesion receptors which mediate interactions between the extracellular matrix and the actin cytoskeleton. They are heterodimers composed of α and β subunits. As adhesion receptors, integrins are important for cell-cell and cell-matrix
Li, Na
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Cdc42 promotes transendothelial migration of cancer cells through β1 integrin. [PDF]
, 2012 Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell ...
Valderrama, F +34 more
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NADPH oxidase (NOX) in the heart : the interplay of NOX-derived ROS in β1-integrin-induced survival signalling [PDF]
, 2011 Moderate levels of reactive oxygen species (ROS) act as mediators in cellular signalling processes. An important source of cardiac ROS is the highly expressed NADPH oxidase (NOX) family isoform NOX2. However, little is known about whether NOX-derived ROS
Rosc-Schlüter, Berit Ines
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Human Parechovirus 1 Infection Occurs via αVβ1 Integrin. [PDF]
PLoS ONE, 2016 Human parechovirus 1 (HPeV-1) (family Picornaviridae) is a global cause of pediatric respiratory and CNS infections for which there is no treatment.
Pirjo Merilahti +2 more
doaj +1 more source
Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation [PDF]
, 2011 Physiological as well as pathological blood vessel formation are fundamentally dependent on cell-matrix interaction. Integrins, a family of major cell adhesion receptors, play a pivotal role in development, maintenance, and remodeling of the vasculature.
Stephan Niland +3 more
core +1 more source