Results 21 to 30 of about 56,023 (262)
Delayed cortical development in mice with a neural specific deletion of β1 integrin
Frontiers in Neuroscience, 2023 The adhesion systems employed by migrating cortical neurons are not well understood. Genetic deletion studies of focal adhesion kinase (FAK) and paxillin in mice suggested that these classical focal adhesion molecules control the morphology and speed of ...
Mamunur Rashid +2 more
doaj +1 more source
β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny. [PDF]
PLoS ONE, 2013 β1 integrin regulates multiple epithelial cell functions by connecting cells with the extracellular matrix (ECM). While β1 integrin-mediated signaling in murine epithelial stem cells is well-studied, its role in human adult epithelial progenitor cells ...
Nancy Ernst +6 more
doaj +1 more source
Effective treatment of HER2-amplified breast cancer by targeting HER3 and β1 integrin [PDF]
Breast Cancer Research and Treatment, 2016 The central role of HER2 as the disease driver and HER3 as its essential partner has made them rational targets for the treatment of HER2-amplifed breast cancers, and there is considerable interest in developing highly effective treatment regimens for this disease that consist of targeted therapies alone.
Campbell, Marcia R +9 more
openaire +4 more sources
New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain
Life Science Alliance, 2022 This study investigates phosphorylation of and kindlin recruitment by the double-threonine motif in the β1 integrin cytoplasmic tails. Integrins require an activation step before ligand binding and signaling that is mediated by talin and kindlin binding ...
Ralph T Böttcher +3 more
doaj +1 more source
Regulation of Renin Expression by Β1-Integrin in As4.1 Juxtaglomerular Line Cells
Biomedicines, 2023 (1) Background: Renal dysfunction and hypertension are mutually aggravating factors; however, the details of their interaction remain unclear. In a study using renal tissue from diabetic rats, we found that β1-integrin, a cell-substrate adhesion molecule,
Nobumichi Saito +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 β1-integrin is a key receptor that regulates cell-ECM interactions and is important in maintaining mature beta-cell functions, including insulin secretion.
Malina Barillaro +5 more
doaj +1 more source
Calreticulin Regulates β1-Integrin mRNA Stability in PC-3 Prostate Cancer Cells
Biomedicines, 2022 Prostate cancer (PCa) is the major cause of cancer-related death among aging men worldwide. Recent studies have suggested that calreticulin (CRT), a multifunctional chaperon protein, may play an important role in the regulation of PCa tumorigenesis and ...
Yueh-Chien Lin +6 more
doaj +1 more source
Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair [PDF]
, 2012 The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment.
Susan McIntyre +13 more
core +1 more source
Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1
Cell Communication and Signaling, 2019 Background Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits. Methods Here we employed biochemical
Juan Gao +12 more
doaj +1 more source
Oncotarget, 2018 // Zhongyu Zhang 1 , Yuan Guan 1 , Xiyao Yu 1 , Hairong Cheng 1 , Yifa Zhou 1 and Guihua Tai 1 1 School of Life Sciences, Northeast Normal University, Changchun, PR China Correspondence to: Guihua Tai, email: taigh477@nenu.edu.cn Keywords : galectin-3; CRD; migration; HMEC-1; β1 integrin Received: August 18, 2017 Accepted ...
Zhongyu Zhang +11 more
openaire +1 more source