The primacy of β1 integrin activation in the metastatic cascade. [PDF]
PLoS ONE, 2012 After neoplastic cells leave the primary tumor and circulate, they may extravasate from the vasculature and colonize tissues to form metastases. β1 integrins play diverse roles in tumorigenesis and tumor progression, including extravasation.
Hisashi Kato +7 more
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β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells.
PLoS ONE, 2014 Astrogliosis with glial scar formation after damage to the nervous system is a major impediment to axonal regeneration and functional recovery. The present study examined the role of β1-integrin signaling in regulating astrocytic differentiation of ...
Liuliu Pan +7 more
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Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer
Cancer Cell International, 2018 Background Integrins play a critical role in carcinogenesis. Integrin β1 localization is regulated by the guanosine-5′-triphosphate hydrolase Rab25 and integrin β1 levels are elevated in the serum of colon cancer patients; thus, the present study ...
Kyung Sook Hong +4 more
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The linkage between β1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of β1 integrin in normal and cancerous human breast cells [PDF]
BMC Cell Biology, 2001 Background Structural requirements for the β1 integrin functions in cell adhesion, spreading and signaling have been well documented mainly for fibroblasts.
Takahashi Kazuhide
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Integrin β1, Osmosensing, and Chemoresistance in Mouse Ehrlich Carcinoma Cells
Cellular Physiology and Biochemistry, 2015 Background/Aims: Altered expression of the integrin family of cell adhesion receptors has been associated with initiation, progression, and metastasis of solid tumors as well as in the development of chemoresistance.
Belinda Halling Sørensen +7 more
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Integrin β1 activation induces an anti-melanoma host response. [PDF]
PLoS ONE, 2017 TGF-β is a cytokine thought to function as a tumor promoter in advanced malignancies. In this setting, TGF-β increases cancer cell proliferation, survival, and migration, and orchestrates complex, pro-tumorigenic changes in the tumor microenvironment ...
Laila Ritsma +7 more
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New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain
Life Science Alliance, 2022 This study investigates phosphorylation of and kindlin recruitment by the double-threonine motif in the β1 integrin cytoplasmic tails. Integrins require an activation step before ligand binding and signaling that is mediated by talin and kindlin binding ...
Ralph T Böttcher +3 more
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Regulation of Renin Expression by Β1-Integrin in As4.1 Juxtaglomerular Line Cells
Biomedicines, 2023 (1) Background: Renal dysfunction and hypertension are mutually aggravating factors; however, the details of their interaction remain unclear. In a study using renal tissue from diabetic rats, we found that β1-integrin, a cell-substrate adhesion molecule,
Nobumichi Saito +7 more
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Frontiers in Cell and Developmental Biology, 2022 β1-integrin is a key receptor that regulates cell-ECM interactions and is important in maintaining mature beta-cell functions, including insulin secretion.
Malina Barillaro +5 more
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Calreticulin Regulates β1-Integrin mRNA Stability in PC-3 Prostate Cancer Cells
Biomedicines, 2022 Prostate cancer (PCa) is the major cause of cancer-related death among aging men worldwide. Recent studies have suggested that calreticulin (CRT), a multifunctional chaperon protein, may play an important role in the regulation of PCa tumorigenesis and ...
Yueh-Chien Lin +6 more
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