Results 11 to 20 of about 56,023 (262)

Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles [PDF]

Journal of Cell Biology, 2019
ABSTRACT Receptor tyrosine kinases (RTKs) are important cargo in endocytic trafficking, yet their role in endosomal sorting and maturation of multivesicular bodies (MVBs) remains unclear. Here we show that the ErbB3 receptor sorts internalised Integrin β1, and the transferrin receptor (TfR), for endocytic recycling, in a manner that ...
Dorival Mendes Rodrigues-Junior, Ana Rosa Sáez-Ibáñez, Takeshi Terabayashi, Nina Daubel, Taija Mäkinen, Olof Idevall-Hagren, Aristidis Moustakas, Ingvar Ferby   +7 more
openaire   +5 more sources

The primacy of β1 integrin activation in the metastatic cascade. [PDF]

PLoS ONE, 2012
After neoplastic cells leave the primary tumor and circulate, they may extravasate from the vasculature and colonize tissues to form metastases. β1 integrins play diverse roles in tumorigenesis and tumor progression, including extravasation.
Huan-You Wang, John V Mitsios, John V. Mitsios (129840), Elena I Deryugina, James P. Quigley (129859), Zhongji Liao, Huan-You Wang (129843), Sanford J Shattil, Judith A. Varner (129854), James P Quigley, Zhongji Liao (36984), Sanford J. Shattil (129865), Judith A Varner, Hisashi Kato (129837), Elena I. Deryugina (129848), Hisashi Kato   +15 more
core   +2 more sources

Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice

Journal of Orthopaedic Translation, 2022
BACKGROUND: The key focal adhesion protein β1 integrin plays an essential role in early skeletal development. However, roles of β1 integrin expression in osteocytes during the regulation of bone homeostasis and mechanotransduction are incompletely ...
Gao, Huanqing, Yao, Qing, Bin Tang, Qing Yao, Sixiong Lin, Wang, Yishu, Xiao, Guozhi, Lei Qin, Zhen Xu, Yi, Weihong, Qin, Lei, Zecai Chen, Tang, Bin, Dazhi Yang, He, Tailin, Qinnan Yan, Xu, Zhen, Yishu Wang, Peijun Zhang, Tailin He, Zhenjian Li, Yan, Qinnan, Weihong Yi, Li, Zhenjian, Zhang, Peijun, Yang, Dazhi, Huanqing Gao, Chen, Zecai, Lin, Sixiong, Guozhi Xiao   +29 more
core   +2 more sources

β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells.

PLoS ONE, 2014
Astrogliosis with glial scar formation after damage to the nervous system is a major impediment to axonal regeneration and functional recovery. The present study examined the role of β1-integrin signaling in regulating astrocytic differentiation of ...
Vibhu Sahni, Tammy L Mcguire, Samuel I Stupp, Hilary A North, Eric J Berns, Liuliu Pan, John A Kessler, Su Ji Jeong   +7 more
core   +2 more sources

Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer

Cancer Cell International, 2018
Background Integrins play a critical role in carcinogenesis. Integrin β1 localization is regulated by the guanosine-5′-triphosphate hydrolase Rab25 and integrin β1 levels are elevated in the serum of colon cancer patients; thus, the present study ...
Soon Sup Chung, Ryung-Ah Lee, Eun-Young Jeon, Kwang Ho Kim, Kyung Sook Hong   +4 more
core   +2 more sources

The linkage between β1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of β1 integrin in normal and cancerous human breast cells

BMC Cell Biology, 2001
Background Structural requirements for the β1 integrin functions in cell adhesion, spreading and signaling have been well documented mainly for fibroblasts.
Kazuhide Takahashi, Takahashi Kazuhide
core   +2 more sources

Integrin β1, Osmosensing, and Chemoresistance in Mouse Ehrlich Carcinoma Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Altered expression of the integrin family of cell adhesion receptors has been associated with initiation, progression, and metastasis of solid tumors as well as in the development of chemoresistance.
Ian Henry Lambert, Sauter, Daniel Rafael Peter, Rasmussen, Line Jee Hartmann, Broberg, Bjørn Sindballe, Hoffmann, Else Kay, Sørensen, Belinda Halling, Bjørn Sindballe Broberg, Klausen, Thomas Kjær, Daniel Peter Rafael Sauter, Thomas Kjær Klausen, Line Jee Hartmann Rasmussen, Anders Aspberg, Belinda Halling Sørensen, Else Kay Hoffmann, Lambert, Ian Henry, Aspberg, Anders   +15 more
core   +2 more sources

Integrin β1 activation induces an anti-melanoma host response. [PDF]

PLoS ONE, 2017
TGF-β is a cytokine thought to function as a tumor promoter in advanced malignancies. In this setting, TGF-β increases cancer cell proliferation, survival, and migration, and orchestrates complex, pro-tumorigenic changes in the tumor microenvironment ...
Ipsita Dey-Guha, Sole, Xavier, Laila Ritsma, Ramaswamy, S., Nilesh Talele, Xavier Sole, Dey-Guha, I., Kenneth N. Ross, Joeeta Chowdhury, null Salony, Chowdhury, J., Sridhar Ramaswamy, Ross, K.N., Kenneth N Ross, Ramaswamy, Sridhar, Salony, Ritsma, L., Ritsma, Laila, Talele, N., Sole, X., Dey-Guha, Ipsita, Chowdhury, Joeeta, Talele, Nilesh, Ross, Kenneth   +23 more
core   +2 more sources

Cancer-specific cytotoxicity of curcumin through regulation of integrin β1 expression in colon cancer. [PDF]

Sci Rep
Curcumin has attracted attention for its nontoxic chemopreventive effects; however, the pathways underlying these effects in colon cancer remain unclear. We investigated the potential interplay between curcumin and integrin β1 in colon cancer.
Kim HK, Lee RA, Hong KS, Noh GT, Oh BY.
europepmc   +2 more sources

Integrin-β1, not integrin-β5, mediates osteoblastic differentiation and ECM formation promoted by mechanical tensile strain

Biological Research, 2015
BACKGROUND: Mechanical strain plays a great role in growth and differentiation of osteoblast. A previous study indicated that integrin-β (β1, β5) mediated osteoblast proliferation promoted by mechanical tensile strain.
Lu Liu, Xianqiong Zou, Ruixin Li, Qiangcheng Zeng, Xizheng Zhang, Yang Wang, Yong Guo, Xinchang Zhang, Yongming Liu   +8 more
core   +2 more sources