Results 51 to 60 of about 56,023 (262)

Role of β1 integrin in thrombocytopoiesis [PDF]

, 2021
: Thrombocytopoiesis is a complex process beginning at the level of hematopoietic stem cells, which ultimately generate megakaryocytes, large marrow cells with a distinctive morphology, and then, through a process of terminal maturation, megakaryocytes ...
Verachi, Paola, Martelli, Fabrizio, Migliaccio, Anna Rita, Mazzarini, Maria   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

β1-integrin/matrix interactions support blood-brain barrier integrity

, 2011
Brain microvascular endothelium forms an active permeability barrier, the blood-brain barrier (BBB). In neurologic disorders, barrier properties of the BBB are often lost indicating their dependance on molecular cues of the brain microenvironment.
Engelhardt, Britta, Britta Engelhardt
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Conditional deletion of β1‐integrin in astroglia causes partial reactive gliosis [PDF]

Astrocytes play many pivotal roles in the adult brain, including their reaction to injury. A hallmark of astrocytes is the contact of their endfeet with the basement membrane surrounding blood vessels, but still relatively little is known about the ...
Dimou, Leda, Zoubaa, Saida, Götz, Magdalena, 26676, 26678, 26677, Goebbels, Sandra, 26679, Schlegel, Jürgen, 26681, 26680, Sirko, Svetlana, 26683, 26682, 100001237, Robel, Stefanie, 30285043, Faissner, Andreas, Mori, Tetsuji, 2308   +19 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion

Journal of Experimental & Clinical Cancer Research, 2018
Background Increasing evidence reveals a significant correlation between gamma-synuclein (SNCG) level and tumor invasion and metastasis in various human cancers. Our previous investigation showed that SNCG could secrete into extracellular environment and
Caiyun Liu, Like Qu, Chuanke Zhao, Chengchao Shou   +3 more
doaj   +1 more source

β1 integrin is essential for blood–brain barrier integrity under stable and vascular remodelling conditions; effects differ with age

Fluids and Barriers of the CNS, 2023
Background Maintaining a tight blood–brain barrier (BBB) is an important prerequisite for the preservation of neurological health, though current evidence suggests it declines with age. While extracellular matrix-integrin interactions play critical roles
Sebok K. Halder, Violaine D. Delorme-Walker, Richard Milner   +2 more
doaj   +1 more source

Expression of integrin β1 by fibroblasts is required for tissue repair in vivo

, 2010
In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue repair, but their tissue-specific role in this process is poorly understood.
Denton, C.P., Xu Shi-wen, Shangxi Liu, Krieg, T., Mark Eastwood, Abraham, D.J., Liu, S., Shi-Wen, X., Christopher P. Denton, David J. Abraham, Andrew Leask, Blumbach, K., Katrin Blumbach, Thomas Krieg, Eastwood, M., Eckes, B., Leask, A., Beate Eckes   +17 more
core   +1 more source

Integrin β1 in Pancreatic Cancer: Expressions, Functions, and Clinical Implications

, 2022
SIMPLE SUMMARY: Pancreatic cancer (PC) is a highly aggressive malignant tumor with an extremely poor prognosis. Early diagnosis and treatment are key to improving the survival rate of PC patients.
Chen, Qun, Zhao, Tiantian, Ziping Ye, Li, Jiajia, Peng, Liyao, Jiajia Li, Jianguo Gu, Sicong Hou, Ye, Ziping, Qinglei Hang, Qun Chen, Tiantian Zhao, Gu, Jianguo, Liyao Peng, Hou, Sicong, Hang, Qinglei   +15 more
core   +1 more source