Results 71 to 80 of about 145,582 (253)

Role of Altered Sialylation of the I-Like Domain of β1 Integrin in the Binding of Fibronectin to β1 Integrin: Thermodynamics and Conformational Analyses [PDF]

, 2010
N-glycosylation of the I-like domain of β1 integrin plays an essential role in integrin structure and function, and the altered sialylation of β1 integrin regulates β1 integrin binding to fibronectin.
Di Pan, Song, Yuhua, Pan, Di, Yuhua Song
core   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Decreased β1 integrin under hypoxia.

, 2016
Representative fluorescent micrographs of β1 integrin abundance under normoxia (A) or hypoxia (C) with the mouse IgG1 isotype control (B and D). Green: β1 integrin, Blue: DAPI.
Hassan Y. Naim (167479), Petra Dersch (183557), Nathalie E. Zeitouni (843137), Maren von Köckritz-Blickwede (311689)   +3 more
core   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

C1GALT1 regulates integrin β1 activity and signaling.

, 2014
(a) The activity of integrin β1 was enhanced in C1GALT1 overexpressing cells. Mock and C1GALT1 transfectants were analyzed by flow cytometry with anti-integrin β1 antibody (left) or anti-activated integrin β1 (HUTS-21) antibody (right).
I-Rue Lai (608592), Yao-Ming Wu (386205), Chia-Hua Chen (234886), Hong-Shiee Lai (301362), Min-Chuan Huang (281425), Rey-Heng Hu (135326), Chiung-Hui Liu (291005), Miao-Juei Huang (281421)   +7 more
core   +1 more source

Beta 1 integrin predicts survival in breast cancer: a clinicopathological and immunohistochemical study

Diagnostic Pathology, 2012
Background The main focus of several studies concerned with cancer progression and metastasis is to analyze the mechanisms that allow cancer cells to interact and quickly adapt with their environment.
dos Santos Petra, Zanetti Juliana S, Ribeiro-Silva Alfredo, Beltrão Eduardo IC   +3 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

Molecular Cancer, 2009
Background Phosphatase of regenerating liver-3 (PRL-3) plays a causative role in tumor metastasis, but the underlying mechanisms are not well understood. In our previous study, we observed that PRL-3 could decrease tyrosine phosphorylation of integrin β1
Wu Jian, Jiang Beihai, Lian Shenyi, Meng Lin, Qu Like, Li Weijun, Xing Xiaofang, Peng Lirong, Shou Chengchao   +8 more
doaj   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Confocal laser scanning micrographs show the double-fluorescence of integrin β1-FAK (A–I), and integrin β1-WT1 (J–R).

, 2014
Under normotensive condition, integrin β1 showed intense staining along the GBM of the glomeruli (A, arrows). FAK was distributed in the cytoplasm and nuclei of the podocytes evenly (B, arrows).
Juan Wang (115708), Zilong Li (245221), Xiaoli Yuan (359671), Xiaohui Yin (547490), Xiaoyue Zhai (547491), Lining Wang (547492), Wei Wang (17594), Kai Li (205203)   +7 more
core   +1 more source