Results 81 to 90 of about 197,418 (252)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer′s disease mice

Neural Regeneration Research, 2016
Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer′s disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential therapeutic strategy for Alzheimer′s disease.
Gao-shang Chai, Yang-yang Wang, Amina Yasheng, Peng Zhao   +3 more
doaj   +1 more source

Transforming Growth Factor-β1 Decreases β2-Agonist–induced Relaxation in Human Airway Smooth Muscle [PDF]

, 2019
Helper T effector cytokines implicated in asthma modulate the contractility of human airway smooth muscle (HASM) cells. We have reported recently that a profibrotic cytokine, transforming growth factor (TGF)-β1, induces HASM cell shortening and airway ...
Corpuz, Maia L., Narayan, Shreya, Williams, Jazmean K., Ostrom, Rennolds S., Schwab, Anthony, Paek, Sam, Nunez, Francisco J., Bexiga, Natalia M., Ojiaku, Christie A., Chung, Elena, Lui, Victoria, Parikh, Vishal, Fuentes, Ana Lucia, An, Kwangmi, An, Steven S., Pannettieri, Reynold A., Jr.   +15 more
core   +1 more source

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

Simulation modeling: an illustrative method to estimate drug clinical and economic effectiveness (retrospective meta-analysis of anti-asthmatic therapy in children in a hospital setting)

Сеченовский вестник, 2017
The article presents an assessment of the clinical, economic and clinical-economic components of the basic anti-asthmatic therapy regimens in children in hospital setting.
O. V. Zhukova
doaj  

Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited by inverse agonists

Communications Biology
The concept of agonist-independent signalling that can be attenuated by inverse agonists is a fundamental element of the cubic ternary complex model of G protein-coupled receptor (GPCR) activation.
Sean A. Cullum, Simon Platt, Natasha Dale, Oliver C. Isaac, Edward S. Wragg, Mark Soave, Dmitry B. Veprintsev, Jeanette Woolard, Laura E. Kilpatrick, Stephen J. Hill   +9 more
doaj   +1 more source

A review of practical strategies for managing bronchial asthma in conventional medical systems

Indian Journal of Allergy Asthma and Immunology
Bronchial asthma is a chronic airway condition affecting about 10%–12% of adults and 15% of children worldwide. Treatment guidelines vary by asthma nature and severity.
Khadija Abdul Hafiz, Kaleem Ahmad, Mohd Aleemuddin Quamri   +2 more
doaj   +1 more source

Clinical Use of β2-adrenergic Receptor Agonists Based on Their Intrinsic Efficacy

Allergology International, 2005
Clinical choice of β2-adrenergic receptor agonists (β2-agonists) is based on the parameter of receptor selectivity, potency, and duration of action. The guidelines for asthma management describe nothing about intrinsic efficacy concerning the use of β2 ...
Hiroaki Kume
doaj   +1 more source

Over-the-counter β2-agonist purchase versus script: A cross-sectional study [PDF]

, 2012
SummaryBackgroundPurchase of short-acting β2-agonist (SABA), but not anti-inflammatory asthma medication, is permitted in Australia without a doctor’s prescription. This has been associated with worse asthma outcomes.
Kay Stewart, Aroni, Rosalie A., Sawyer, Susan M., Edwina A. McCarthy, Goeman, Dianne P., Dianne P. Goeman, Rosalie A. Aroni, Jo A. Douglass, Abramson, Michael J., McCarthy, Edwina A., Stewart, Kay, Douglass, Jo A., Susan M. Sawyer, Michael J. Abramson   +13 more
core   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source