Results 81 to 90 of about 159,798 (214)

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Predictors of excessive short-acting β₂-agonist use and asthma exacerbations: a retrospective analysis of a Polish prescription database. [PDF]

Postepy Dermatol Alergol, 2023
Kupczyk M, Barg W, Bochenek G, Brożek G, D Browiecki P, Brzostek D, D Browski A, Dobek R, Gawlik R, Kucharczyk A, Kupryś-Lipińska I, Mastalerz-Migas A, Kowalski ML.   +12 more
europepmc   +1 more source

Daily Injection of the β2 Adrenergic Agonist Clenbuterol Improved Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and Hyperlipidemia in Juvenile Lambs Following Heat-Stress-Induced Intrauterine Growth Restriction

Stress-induced fetal programming diminishes β2 adrenergic tone, which coincides with intrauterine growth restriction (IUGR) and lifelong metabolic dysfunction. We determined if stimulating β2 adrenergic activity in IUGR-born lambs would improve metabolic
Rachel L. Gibbs, James A. Wilson, Rebecca M. Swanson, Eileen S. Marks-Nelson, Haley N. Beer, Zena M. Hicks, Ty B. Schmidt, Dustin T. Yates, Jessica L. Petersen, Joslyn K. Beard   +9 more
core   +1 more source

How β2-selective is the adrenoceptor antagonist drug, IPS 339?

, 1981
Schild plots for the compound (t-butylamino-3-ol-2-propyl)oximino-9-fluorene (IPS 339) have been obtained on isolated intrinsic tone trachea and atria (rate) of guinea-pigs. α-Adrenoceptors and uptakes were inhibited.
STELLA R O'DONNELL, KARIN WALDUCK
core   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Short-acting β₂-agonist Prescription Patterns in Patients with Asthma in the Philippines: Results from SABINA III. [PDF]

Acta Med Philipp, 2023
Diaz DV, Nicodemus LA, Parena-Santiago EL, Capalla MEV, Samoro RZ, Bayate-Jabines BK, Orcasitas JF, Hernandez-Matibag M, Matibag RS, Bernardo JC, Garcia EFH, Beekman MJ.   +11 more
europepmc   +1 more source

STUDI PENGGUNAAN OBAT GOLONGAN β2-AGONIS PADA PASIEN ASMA (Penelitian dilakukan di Instalasi Rawat Jalan Paru RSUD Dr. Soetomo Surabaya) [PDF]

, 2016
Background. Asthma is a hetergenous disease and usually characterized by chronic airway inflamation. Another study declare that prevalence of asthma in Indonesia were increased.
ANINDYA CARIMA, 051211131062
core  

Mucociliary clearance in COPD can be increased by both a D2/β2 and a standard β2 agonists

, 2005
SummaryIn addition to breathlessness and cough, excessive mucus production is one of the main symptoms of chronic obstructive pulmonary disease (COPD).
Lloyd, J., Agnew, J.E., Hasani, A., Dilworth, J.P., Toms, N.   +4 more
core   +1 more source

A Real‐World Controlled Multicentre Study Evaluating the Association Between Benralizumab Therapy and Major Outcomes in Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Among patients with severe eosinophilic asthma, benralizumab was associated with greater improvements in asthma outcomes—such as improved asthma control, quality of life and remission rates—compared to biologic‐naïve patients. ABSTRACT Background Real‐world data on benralizumab in patients with severe eosinophilic asthma–while controlling for ...
Dennis Thomas, Vanessa M. McDonald, Gijo Thomas, Joy Lee, Li Ping Chung, Matthew Peters, Shakti D. Shukla, Yuto Hamada, Erin S. Harvey, Michael Fricker, Hayley See, Rejoy Sabin Thomas, Claude S. Farah, Andrew Gillman, Constance H. Katelaris, Gregory P. Katsoulotos, David Langton, Peter G. Middleton, Paul Reynolds, Janet Rimmer, Francis Thien, Stephen Vincent, John W. Upham, Peter G. Gibson   +23 more
wiley   +1 more source

Estimating Inhaled Corticosteroid Exposure from Short-Acting β₂-Agonist-Inhaled Corticosteroid Rescue. [PDF]

J Asthma Allergy, 2023
Lugogo N, Gilbert I, Pollack M, Gandhi H, Tkacz J, Lanz MJ.   +5 more
europepmc   +1 more source