Results 101 to 110 of about 159,798 (214)

A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes. [PDF]

Biofactors, 2022
Melis M, Tang XH, Attarwala N, Chen Q, Prishker C, Qin L, Gross SS, Gudas LJ, Trasino SE.   +8 more
europepmc   +1 more source

How L2 Learners Negotiate Meaning in GenAI‐Supported Creative Writing

International Journal of Applied Linguistics, EarlyView.
ABSTRACT This qualitative study explores how second language (L2) learners negotiate meaning and co‐construct knowledge with generative AI (GenAI) in a 12‐week multimodal creative writing project. Chinese middle school students (N = 75) created English picture books using a conversational GenAI agent supporting textual and text‐to‐image generation.
Zhihui Zhang, Scott Aubrey, Zihao Guo, Thomas K. F. Chiu   +3 more
wiley   +1 more source

A retinoic acid receptor β2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease. [PDF]

J Biol Chem, 2021
Tang XH, Melis M, Lu C, Rappa A, Zhang T, Jessurun J, Gross SS, Gudas LJ.   +7 more
europepmc   +1 more source

Circadian Deregulation in Multiple Myeloma: BMAL1/CLOCK Expression Patterns and Diagnostic Performance

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Circadian clock disruption has emerged as a relevant axis in cancer; however, the expression patterns and diagnostic relevance of BMAL1 and CLOCK in multiple myeloma (MM) remain insufficiently defined. Methods BMAL1 and CLOCK mRNA expression was quantified by RT‐qPCR in bone marrow samples from 46 newly diagnosed MM patients and 13 ...
Hamide Albayrak, Mustafa Ertan Ay, Anıl Tombak, Kenan Çevik, Özlem İzci Ay, Tuba Kabasakal, Mehmet Emin Erdal   +6 more
wiley   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

Short-acting β₂-agonist prescription patterns and clinical outcomes in Malaysia: A nationwide cohort of the SABINA III study. [PDF]

Malays Fam Physician, 2023
Ban AY, Vengadasalam P, Taher SW, Mohd Zim MA, Sirol Aflah SS, Daut UN, Hyder Ali IA, Pereirasamy L, Omar A, Ibrahim A, Mohd Tarekh NA, Chan SK, Ali N, Mohd Isa NA, Hussain H, Abdul Karim N, Raja Gopal V, Chiam SY, Beekman MJHI.   +18 more
europepmc   +1 more source

Neural modulation of ocular immunity: Exploring a sympathetic‐macrophage neuroimmune link in the human ciliary body

Journal of Anatomy, EarlyView.
Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou, Claire Mackaaij, Mark van Zijverden, Hendrik A. Messal, Jeannette Ossewaarde‐van Norel, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +6 more
wiley   +1 more source

Short-acting β₂ -agonist use and asthma exacerbations in Swedish children: A SABINA Junior study. [PDF]

Pediatr Allergy Immunol, 2022
Melén E, Nwaru BI, Wiklund F, de Fine Licht S, Telg G, Maslova E, van der Valk RJP, Tran TN, Ekström M, Janson C.   +9 more
europepmc   +1 more source

The changing epidemiology of human type 2 diabetes–associated atherosclerosis: Pathophysiological mechanisms and emerging treatment possibilities

Journal of Internal Medicine, EarlyView.
Abstract Type 2 diabetes (T2D) is a major global health concern strongly associated with atherosclerosis and subsequent macrovascular complications. These complications are the leading cause of death among T2D patients. Despite a decline in cardiovascular events over the last decade, individuals with T2D still have an approximately doubled risk ...
Dania Al‐Sharify, Jiangming Sun, Andreas Edsfeldt   +2 more
wiley   +1 more source

Short-acting β₂-agonist prescription patterns for asthma management in the SABINA III primary care cohort. [PDF]

NPJ Prim Care Respir Med, 2022
Price D, Hancock K, Doan J, Taher SW, Muhwa CJ, Farouk H, Beekman MJHI.   +6 more
europepmc   +1 more source