Results 101 to 110 of about 197,418 (252)

Effect of Procaterol, a β2 Selective Adrenergic Receptor Agonist, on Airway Inflammation and Hyperresponsiveness [PDF]

, 2007
Backgroundβ-agonists are frequently used as bronchodilators for asthma as not only a reliever but also a controller, and their utility has increased with the development of long-acting β2 selective drugs. Although antiinflammatory effects of β2 selective-
Nagase, Hiroyuki, Hisanao Yoshihara, Yamashita, Naomi, Hirofumi Ishida, Adachi, Tetsuya, Nakano, Junichi, Tashimo, Hiroyuki, Tomoko Yano, Hiroyuki Nagase, Ishida, Hirofumi, Hiroyuki Tashimo, Tetsuya Adachi, Junichi Nakano, Ohta, Ken, Yano, Tomoko, Ken Ohta, Yamamura, Koichi, Naomi Yamashita, Koichi Yamamura, Yoshihara, Hisanao   +19 more
core   +1 more source

Synthesis of Microbial‐Derived Octadecanoids

Lipids, EarlyView.
C18‐carbon containing dietary polyunsaturated fatty acids (e.g., linoleic acid, α‐linolenic acid, and γ‐linolenic acid) are metabolized by bacteria in the gut into oxygenated lipid mediators termed octadecanoids. To study the biological function of these compounds, we report here the chemical synthesis of multiple octadecanoids.
Johanna Revol‐Cavalier, Katarína Bankóová, Olivier Salamin, Alessandro Quaranta, Juan Du, Mats Hamberg, Craig E. Wheelock   +6 more
wiley   +1 more source

Effect of short- and long-acting β2-adrenoceptor agonists on pulmonary β2-adrenoceptor expression in human lung

, 1996
β-Adrenoceptor agonists induce the down-regulation of β2-adrenoceptors and mRNA expression in animal lung. The down-regulation of β2-adrenoceptors may limit the therapeutic efficacy of β2-adrenoceptor-mediated bronchodilators in obstructive airways ...
Barnes, PJ, Mak, JCW, Nishikawa, M
core   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Ursodeoxycholic Acid and Parkinson's Disease Risk: An Emulated Target Trial in UK Electronic Health Records

Movement Disorders, EarlyView.
Abstract Background Ursodeoxycholic acid (UDCA) has shown mitochondrial and neuroprotective effects and has been proposed as a treatment for Parkinson's disease (PD). However, population‐level evidence on its effect on PD risk is lacking. Objectives To compare the risk of incident PD among UDCA initiators versus matched non‐initiators within a ...
Chengsheng Ju, Anette Schrag, Camille Carroll, Xi Xiong, James Carpenter, Oliver Bandmann, Thomas Foltynie, Li Wei   +7 more
wiley   +1 more source

Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells

Journal of Pharmacological Sciences, 2018
Insulin resistance is a condition in which there is a defect in insulin actions to induce glucose uptake into the cells. Overstimulation of β2-adrenergic receptors (β2ARs) is associated with the pathogenesis of insulin resistance in the heart.
Warisara Parichatikanond, Akiyuki Nishimura, Motohiro Nishida, Supachoke Mangmool   +3 more
doaj   +1 more source

Discovery of a Potent, Orally Available, and Isoform-Selective Retinoic Acid β2 Receptor Agonist

, 2016
4‘-Octyl-4-biphenylcarboxylic acid (1g, AC-55649) was identified as a highly isoform-selective agonist at the human RARβ2 receptor in a functional intact cell-based screening assay.
Natalie K. Gauthier (2384398), Vladimir Sherbukhin (2417572), Roger Olsson (1399453), Erika Currier (2661499), Anne Eeg (2661493), Birgitte W. Lund (2335357), Fabrice Piu (2335363), Uli Hacksell (2384404), Mark R. Brann (2661496)   +8 more
core   +2 more sources

The importance of choice of agonist in studies designed to predict β2:β1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria

, 1979
1. pA2 values have been obtained for propranolol, butoxamine, H35/25 and atenolol on guinea-pig isolated trachea and atria (rate) using noradrenaline (β1-selective), isoprenaline (non-selective) and fenoterol (β2-selective) as agonists. 2.
O'Donnell S.R., Wanstall J.C.
core   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source