Results 211 to 220 of about 33,979 (285)

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, EarlyView.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source

<i>Ex vivo</i> cytokine responses and metabolic reprogramming are associated with γδ T cell differentiation in <i>Plasmodium falciparum</i> placental malaria. [PDF]

Front Immunol
Nana Mbianda CM, Kwanou Tchakounte BD, Bitye Zambo BM, Ntankheuh Tchinkou J, Atchombat Nyasse D, Fogang B, Argüello RJ, Ayong L, Megnekou R.   +8 more
europepmc   +1 more source

Single-Cell Signalling Analysis of γδ T Cell Biotherapeutics for the Treatment of Colorectal Cancer

Colorectal cancer (CRC) is a devastating disease that is responsible for the deaths of >900,000 people worldwide annually, with immunotherapies struggling against the immunosuppressive CRC tumour microenvironment (TME).
Nattress, Callum Baird
core  

Evolution and Phylogenetics of the Javan Hawk‐Eagle Nisaetus bartelsi (Stresemann, 1924) Using Mitochondrial Data 爪哇鹰雕 Nisaetus bartelsi (Stresemann, 1924) 基于线粒体数据的演化与系统发育研究

Integrative Conservation, EarlyView.
This study reconstructs the phylogeny of the Javan Hawk‐Eagle (Nisaetus bartelsi) within the subfamily Aquilinae using Maximum Likelihood and Bayesian Inference algorithms on a blood sample and GenBank data. The analysis reveals that the sampled genus Nisaetus forms a monophyletic group. Furthermore, N. bartelsi occupies a sister‐taxon of N.
Almas Lathifatul Ula, Tuty Arisuryanti, Rury Eprilurahman, Dwi Sendi Priyono   +3 more
wiley   +1 more source

cGAS/STING-mediated γδ T cell recruitment drives radioresistance: implications for improving radioimmunotherapy outcomes. [PDF]

J Clin Invest
Braman BC, Raleigh DR.
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Black phosphorus‐based photothermal disruption of cancer‐associated fibroblast barriers and tumor‐associated macrophage targeting to enhance anti‐PD‐L1 immunotherapy in triple‐negative breast cancer

Interdisciplinary Medicine, EarlyView.
MBB modulates the TNBC tumor microenvironment by targeting TAM/CXCL1 and facilitates anti‐PD‐L1 therapy by disrupting CAF barriers via its photothermal effect. This combined strategy subsequently enhances the efficacy of PD‐L1 mAb and suppresses TNBC progression, metastasis, and recurrence.
Bo Pan, Shicui Hong, Xinyue Wang, Yanghang Li, Cai Wang, Yaxiao Liu, Ying Chen, Chen Fang, Yifeng Zheng, Shengqi Wang, Juping Zhang, Neng Wang, Zhiyu Wang   +12 more
wiley   +1 more source

αPD-L1-γδ T cell conjugates: expanding function beyond direct tumor killing. [PDF]

Natl Sci Rev
Wang X, Wu P.
europepmc   +1 more source

c‐Met‐Targeted Imaging Agents: Progress and Challenges

iRADIOLOGY, EarlyView.
This review summarizes recent advances in c‐Met‐targeted imaging probes, including hepatocyte growth factor (HGF) ligands, antibodies, peptides, and small molecules across magnetic resonance imaging (MRI), positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and optical imaging modalities.
Yonghao Li, Aiyan Ji, Qihang Ding, Hongyue Lou, Zhen Cheng   +4 more
wiley   +1 more source

Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases. [PDF]

Dis Model Mech
Santillo D, Bellos E, Sancho-Shimizu V.
europepmc   +1 more source