Single-cell omics and flow cytometry identify distinct immune states of dural and brain-infiltrating IL-17-producing γδ T cells after experimental stroke [PDF]
Journal of NeuroinflammationBackground γδ T cells boost inflammatory responses and exacerbate tissue damage after ischemic stroke. However, the origin, dynamics, and tissue adaptation of γδ T cells in the ischemic brain and its border regions remain poorly understood.
Mingming Zha +7 more
doaj +2 more sources
Characterization of Stimulated γδ T Cells: Phenotypic Analysis and Implications for Allogeneic Cellular Immunotherapy [PDF]
CellsDue to their anti-tumor activity and non-major histocompatibility complex (MHC) binding T cell receptor, γδ T cells are suitable candidates for allogeneic cellular immunotherapy in cancer.
Anna Bold +5 more
doaj +2 more sources
Fitness Training for γδ T cells in mouse and human atherosclerosis takes place in plaques and artery tertiary lymphoid organs [PDF]
Genome MedicineBackground γδ T cells represent a heterogeneous family of innate-like lymphocytes with adaptive immunity features. Although abundant in barrier tissues such as skin and intestine, γδ T cells are rare in the cardiovascular system, which severely limits ...
Zhihua Wang +20 more
doaj +2 more sources
Comparing Mouse and Human Tissue-Resident γδ T Cells
Frontiers in Immunology, 2022 Circulating immune cell compartments have been extensively studied for decades, but limited access to peripheral tissue and cell yield have hampered our understanding of tissue-based immunity, especially in γδ T cells. γδ T cells are a unique subset of T
Guanyu Qu +5 more
doaj +1 more source
Engineering γδ T Cells: Recognizing and Activating on Their Own Way
Frontiers in Immunology, 2022 Adoptive cell therapy (ACT) with engineered T cells has emerged as a promising strategy for the treatment of malignant tumors. Among them, there is great interest in engineered γδ T cells for ACT.
Ruoyu Dong +3 more
doaj +1 more source
Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]
PLoS ONE, 2018 Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Dongchun Liang +6 more
doaj +1 more source
γδ T Cells in Brain Homeostasis and Diseases
Frontiers in Immunology, 2022 γδ T cells are a distinct subset of T cells expressing γδ T cell receptor (TCR) rather than αβTCR. Since their discovery, the critical roles of γδ T cells in multiple physiological systems and diseases have been investigated.
Jang Hyun Park, In Kang, Heung Kyu Lee
doaj +1 more source
Cell Death and Disease, 2022 Liver fibrosis represents a severe stage of liver damage, with hallmarks of inflammation, hepatic stellate cell activation, and extracellular matrix accumulation.
Qihui Liu +21 more
doaj +1 more source
γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation. [PDF]
PLoS ONE, 2013 Both antigen recognition and CD28 costimulation are required for the activation of naïve αβ T cells and their subsequent differentiation into cytokine-producing or cytotoxic effectors.
Renee M Laird +3 more
doaj +1 more source
Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation. [PDF]
PLoS ONE, 2013 Gammadelta (γδ) T lymphocytes respond quickly upon antigen encounter to produce a cytokine response. In this study, we sought to understand how functions of γδ T cells are differentially regulated compared to αβ T cells.
Hsin-Yuan Cheng +7 more
doaj +1 more source