Results 1 to 10 of about 31,357 (216)
Divergent cytotoxic and inflammatory functions of intratumoral Vδ2+ γδ T cells in renal cell carcinoma [PDF]
Frontiers in ImmunologyVγ9Vδ2 T cells are blood-circulating, innate-like lymphocytes that contribute to tumor immunosurveillance and constitute over 95% of Vδ2+ γδ T cells, but how they perform antitumor or protumor functions remains unclear.
Won Joon Oh +13 more
doaj +2 more sources
Killer-cell immunoglobulin-like receptors define a potent effector program in human γδ T cells [PDF]
JCI InsightHuman γδ T cells are a rare but functionally diverse lymphocyte subset critical for tumor surveillance and antimicrobial immunity. Although they express NK cell–associated receptors such as killer-cell immunoglobulin-like receptors (KIRs), the relevance ...
Mahya Razmi +5 more
doaj +2 more sources
Comparing Mouse and Human Tissue-Resident γδ T Cells
Frontiers in Immunology, 2022 Circulating immune cell compartments have been extensively studied for decades, but limited access to peripheral tissue and cell yield have hampered our understanding of tissue-based immunity, especially in γδ T cells. γδ T cells are a unique subset of T
Guanyu Qu +5 more
doaj +1 more source
Engineering γδ T Cells: Recognizing and Activating on Their Own Way
Frontiers in Immunology, 2022 Adoptive cell therapy (ACT) with engineered T cells has emerged as a promising strategy for the treatment of malignant tumors. Among them, there is great interest in engineered γδ T cells for ACT.
Ruoyu Dong +3 more
doaj +1 more source
γδ T Cells in Brain Homeostasis and Diseases
Frontiers in Immunology, 2022 γδ T cells are a distinct subset of T cells expressing γδ T cell receptor (TCR) rather than αβTCR. Since their discovery, the critical roles of γδ T cells in multiple physiological systems and diseases have been investigated.
Jang Hyun Park, In Kang, Heung Kyu Lee
doaj +1 more source
Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]
PLoS ONE, 2018 Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Dongchun Liang +6 more
doaj +1 more source
Cell Death and Disease, 2022 Liver fibrosis represents a severe stage of liver damage, with hallmarks of inflammation, hepatic stellate cell activation, and extracellular matrix accumulation.
Qihui Liu +21 more
doaj +1 more source
γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation. [PDF]
PLoS ONE, 2013 Both antigen recognition and CD28 costimulation are required for the activation of naïve αβ T cells and their subsequent differentiation into cytokine-producing or cytotoxic effectors.
Renee M Laird +3 more
doaj +1 more source
Frontiers in Immunology, 2018 T lymphocytes expressing the γδ T cell receptor (γδ TCR) can recognize antigens expressed by tumor cells and subsequently kill these cells. γδ T cells are indeed used in cancer immunotherapy clinical trials.
Claudia Juraske +30 more
doaj +1 more source
D-Mannose Suppresses γδ T Cells and Alleviates Murine Psoriasis
Frontiers in Immunology, 2022 Psoriasis is a chronic skin disorder associated with multiple sequelae, such as psoriatic arthritis and cardiovascular diseases. Increasing evidence has shown that γδ T cells, as sources of IL-17A, play critical roles in psoriatic inflammations. However,
Mingyang Li +22 more
doaj +1 more source