Results 1 to 10 of about 1,803,893 (333)

Hepatocellular carcinoma‐infiltrating γδ T cells are functionally defected and allogenic Vδ2+ γδ T cell can be a promising complement

Clinical and Translational Medicine, 2022
In hepatocellular carcinoma (HCC), γδ T cells participate in mediating the anti‐tumour response and are linked with a positive prognosis. However, these cells can become pro‐tumoural in the tumour microenvironment (TME).
Wenjing He, Yi Hu, Dan Chen, Yijia Li, Dongmei Ye, Qiang Zhao, Li Lin, Xiaomin Shi, Ligong Lu, Zhinan Yin, Xiaoshun He, Yifang Gao, Yangzhe Wu   +12 more
doaj   +3 more sources

Comparing Mouse and Human Tissue-Resident γδ T Cells

Frontiers in Immunology, 2022
Circulating immune cell compartments have been extensively studied for decades, but limited access to peripheral tissue and cell yield have hampered our understanding of tissue-based immunity, especially in γδ T cells. γδ T cells are a unique subset of T
Guanyu Qu, Shengli Wang, Zhenlong Zhou, Dawei Jiang, Aihua Liao, Jing Luo   +5 more
doaj   +2 more sources

Engineering γδ T Cells: Recognizing and Activating on Their Own Way

Frontiers in Immunology, 2022
Adoptive cell therapy (ACT) with engineered T cells has emerged as a promising strategy for the treatment of malignant tumors. Among them, there is great interest in engineered γδ T cells for ACT.
Ruoyu Dong, Yixi Zhang, Haowen Xiao, Xun Zeng   +3 more
doaj   +2 more sources

Gamma-delta (γδ) T cells: friend or foe in cancer development?

Journal of Translational Medicine, 2018
Background γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity.
Yijing Zhao, Chao Niu, Jiuwei Cui
doaj   +2 more sources

Characterization of Stimulated γδ T Cells: Phenotypic Analysis and Implications for Allogeneic Cellular Immunotherapy [PDF]

Cells
Due to their anti-tumor activity and non-major histocompatibility complex (MHC) binding T cell receptor, γδ T cells are suitable candidates for allogeneic cellular immunotherapy in cancer.
Anna Bold, Heike Gross, Marco Bardenbacher, Elisabeth Holzmann, Stefan Knop, Martin Wilhelm   +5 more
doaj   +2 more sources

Fitness Training for γδ T cells in mouse and human atherosclerosis takes place in plaques and artery tertiary lymphoid organs [PDF]

Genome Medicine
Background γδ T cells represent a heterogeneous family of innate-like lymphocytes with adaptive immunity features. Although abundant in barrier tissues such as skin and intestine, γδ T cells are rare in the cardiovascular system, which severely limits ...
Zhihua Wang, Ting Sun, Yixin Zhang, Yutao Li, Chuankai Zhang, Xinwen Dou, Xinyi Deng, Zhipeng Li, Jingpu Zhu, Mingyang Hong, Yi Ran, Shu Wang, Liping Li, Junjie Zheng, Cong Wen, Xi Zhang, Shu Lu, Sagar, Sarajo K. Mohanta, Andreas J.R. Habenicht, Changjun Yin   +20 more
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γδ T cells: origin and fate, subsets, diseases and immunotherapy

Signal Transduction and Targeted Therapy, 2023
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune renormalization as a promising strategy in disease treatment.
Yi Hu, Qinglin Hu, Yongsheng Li, Ligong Lu, Z. Xiang, Z. Yin, Dieter Kabelitz, Yangzhe Wu   +7 more
semanticscholar   +1 more source

γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

Nature, 2023
DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that is thought to explain their exceptional responsiveness to immune checkpoint blockade (ICB)^ 1 , 2 .
Natasja L. de Vries, J. van de Haar, Vivien Veninga, M. Chalabi, M. Ijsselsteijn, Manon van der Ploeg, J. van den Bulk, D. Ruano, J. G. van den Berg, J. Haanen, L. Zeverijn, B. Geurts, G. F. de Wit, Thomas W Battaglia, H. Gelderblom, H. Verheul, T. Schumacher, L. Wessels, F. Koning, N. D. de Miranda, E. Voest   +20 more
semanticscholar   +1 more source

Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]

PLoS ONE, 2018
Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Dongchun Liang, Jeong-Im Woo, Hui Shao, Willi K Born, Rebecca L O'Brien, Henry J Kaplan, Deming Sun   +6 more
doaj   +1 more source

γδ T Cells in Brain Homeostasis and Diseases

Frontiers in Immunology, 2022
γδ T cells are a distinct subset of T cells expressing γδ T cell receptor (TCR) rather than αβTCR. Since their discovery, the critical roles of γδ T cells in multiple physiological systems and diseases have been investigated.
Jang Hyun Park, In Kang, Heung Kyu Lee
doaj   +1 more source