Preclinical platforms to study therapeutic efficacy of human γδ T cells
Clinical and Translational Medicine, 2022 Background Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell therapy, however, their treatment efficacy is not satisfactory.
Lingling Ou +14 more
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A close look at current γδ T-cell immunotherapy
Frontiers in Immunology, 2023 Owing to their antitumor and major histocompatibility complex (MHC)-independent capacities, γδ T cells have gained popularity in adoptive T-cell immunotherapy in recent years. However, many unknowns still exist regarding γδ T cells, and few clinical data
Ling Ma +3 more
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A Novel Prothrombotic Pathway in Systemic Sclerosis Patients: Possible Role of Bisphosphonate-Activated γδ T Cells [PDF]
Frontiers in Immunology, 2014 Infusions of aminobisphonates (ABP) activate Vγ9δ2T cells in vivo and induce an acute inflammatory response in 30% of patients treated for osteoporosis. Following the observation of digital thrombosis in a systemic sclerosis (SSc) patient after treatment with an intravenous ABP, zoledronate (Zol), we evaluated whether patient and control peripheral ...
Victoria eMarcu-Malina +6 more
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Distribution and functions of γδ T cells infiltrated in the ovarian cancer microenvironment
Journal of Translational Medicine, 2019 Background The role of γδ T cells, innate-like lymphocytes with unrestrained MHC, in various malignancies has recently been extensively studied. However, there is limited research regarding γδ T cells in ovarian cancer (OC) patients.
Xian Chen +7 more
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Single-cell differentiation trajectories define early stages of a human cutaneous T-cell lymphoma
Exploration of Immunology, 2022 Aim: The aim of this article is to characterize in detail the γδ T lymphocytes from an adult patient with primary cutaneous T-cell lymphoma of γδ subtype (γδ CTCL). Methods: Here this article reports trajectory mapping on high-resolution differentiation
Juan-Pablo Cerapio +5 more
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Pathogen-Specific Immune Fingerprints during Acute Infection: The Diagnostic Potential of Human γδ T-Cells [PDF]
Frontiers in Immunology, 2014 The last 200 years have seen a dramatic reduction in the prevalence and severity of microbial infections, due to the implementation of groundbreaking measures ranging from improved sanitation and hygiene and the introduction of aseptic techniques to the development of successful vaccines and the discovery of effective antibiotics.
Matthias eEberl +5 more
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Gamma-delta (γδ) T cells: friend or foe in cancer development?
Journal of Translational Medicine, 2018 Background γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity.
Yijing Zhao, Chao Niu, Jiuwei Cui
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Obesity impairs γδ T cell homeostasis and antiviral function in humans. [PDF]
PLoS ONE, 2015 Obese patients are susceptible to increased morbidity and mortality associated with infectious diseases such as influenza A virus. γδ T cells and memory αβ T cells play key roles in reducing viral load by rapidly producing IFN-γ and lysing infected cells.
Anne E Costanzo +5 more
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A Highly Focused Antigen Receptor Repertoire Characterizes γδ T Cells That are Poised to Make IL-17 Rapidly in Naive Animals [PDF]
Frontiers in Immunology, 2015 Interleukin (IL)-17 plays a key role in immunity. In acute infections, a rapid IL-17 response must be induced without prior antigen exposure, and γδ T cells are the major initial IL-17 producers. In fact, some γδ T cells make IL-17 within hours after an immune challenge. These cells appear to acquire the ability to respond to IL-1 and IL-23 and to make
Yu-Ling eWei +8 more
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Human γδ T Cells Augment Antigen Presentation in Listeria Monocytogenes Infection
Molecular Medicine, 2016 Circulating γδ T cells In healthy Individuals rapidly respond to bacterial and viral pathogens. Many studies have demonstrated that γδ T cells are activated and expanded by Listeria monocytogenes (L.
Yuli Zhu +7 more
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