Results 41 to 50 of about 1,803,893 (333)

Double-edged sword: γδ T cells in mucosal homeostasis and disease

Experimental and Molecular Medicine, 2023
The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in direct contact with pathogens, and γδ T cells perform various roles in the tissue. γδ T cells efficiently
In Kang, Yumin Kim, Heung Kyu Lee
doaj   +1 more source

Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation [PDF]

Frontiers in Immunology, 2015
Despite effective anti-viral therapies, cytomegalovirus (CMV) is still associated with direct (CMV disease) and indirect effects (rejection and poor graft survival) in kidney transplant recipients. Recently, an unconventional T cell population (collectively designated as Vδ2(neg) γδ T cells) has been characterized during the anti-CMV immune response in
Couzi, Lionel, Pitard, Vincent, Moreau, Jean-François, Merville, Pierre, Déchanet-Merville, Julie   +4 more
openaire   +2 more sources

D-Mannose Suppresses γδ T Cells and Alleviates Murine Psoriasis

Frontiers in Immunology, 2022
Psoriasis is a chronic skin disorder associated with multiple sequelae, such as psoriatic arthritis and cardiovascular diseases. Increasing evidence has shown that γδ T cells, as sources of IL-17A, play critical roles in psoriatic inflammations. However,
Mingyang Li, Mingyang Li, Mingyang Li, Mingyang Li, Haiyan Cheng, Dan Tian, Dan Tian, Dan Tian, Dan Tian, Lu Yang, Lu Yang, Lu Yang, Xiaonan Du, Xiaonan Du, Xiaonan Du, Yuhualei Pan, Yuhualei Pan, Yuhualei Pan, Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang, Xueling Mei   +22 more
doaj   +1 more source

Exosomes derived from γδ-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment

Journal for ImmunoTherapy of Cancer, 2022
Background Radiotherapy is the first-line treatment for patients nasopharyngeal carcinoma (NPC), but its therapeutic efficacy is poor in some patients due to radioresistance.
Xiwei Wang, Yanmei Zhang, Xiao-Xin Mu, Chloe Ran Tu, Yue-Lin Chung, S. Tsao, G. C. Chan, W. Leung, Y. Lau, Yinping Liu, W. Tu   +10 more
semanticscholar   +1 more source

Multiple Receptor-Ligand Interactions Direct Tissue-Resident γδ T Cell Activation [PDF]

Frontiers in Immunology, 2014
γδ T cells represent a major T cell population in epithelial tissues, such as skin, intestine, and lung, where they function in maintenance of the epithelium and provide a crucial first line defense against environmental and pathogenic insults. Despite their importance, the molecular mechanisms directing their activation and function have remained ...
Witherden, Deborah. A., Ramirez, Kevin, Havran, Wendy L.   +2 more
openaire   +2 more sources

High level expression of A2ARs is required for the enhancing function, but not for the inhibiting function, of γδ T cells in the autoimmune responses of EAU.

PLoS ONE, 2018
We previously reported that activated γδ T cells greatly enhance autoimmune responses, particularly the Th17 response. To determine the mechanisms involved, we made a series of comparisons between activated and non-activated γδ T cells.
Dongchun Liang, Hui Shao, Willi K Born, Rebecca L O'Brien, Henry J Kaplan, Deming Sun   +5 more
doaj   +1 more source

Phosphoantigen-stimulated γδ T cells suppress natural killer cell–responses to missing-self

, 2022
γδ T cells stimulated by phosphoantigens (pAg) are potent effectors that secrete Th1 cytokines and kill tumor cells. Consequently, they are considered candidates for use in cancer immunotherapy.
Cocker, Alexander T. H., Djaoud, Zakia, Parham, Peter, Beyzaie, Niassan, Guethlein, Lisbeth A., Pugh, Jason, Olive, Daniel, Cocker, Alexander T H, Walwyn-Brown, Katherine, Singer, Bernhard B.   +9 more
core   +1 more source

IL17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Nature, 2015
Metastatic disease remains the primary cause of death for patients with breast cancer. The different steps of the metastatic cascade rely on reciprocal interactions between cancer cells and their microenvironment.
S. Coffelt, K. Kersten, C. Doornebal, Jorieke Weiden, K. Vrijland, Cheei-Sing Hau, N. J. Verstegen, M. Ciampricotti, L. Hawinkels, J. Jonkers, K. D. de Visser   +10 more
semanticscholar   +1 more source

Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

Nature Immunology, 2020
Interleukin (IL)-17a has been highly conserved during evolution of the vertebrate immune system and widely studied in contexts of infection and autoimmunity.
Kalil Alves de Lima, Justin Rustenhoven, Sandro Da Mesquita, Morgan K. Wall, A. F. Salvador, I. Smirnov, Guilherme Martelossi Cebinelli, Tornike Mamuladze, Wendy Baker, Zachary Papadopoulos, M. Lopes, W. Cao, X. Xie, Jasmin Herz, J. Kipnis   +14 more
semanticscholar   +1 more source

Cancer Immunotherapy Using γδT Cells: Dealing with Diversity [PDF]

Frontiers in Immunology, 2014
The broad and potent tumor-reactivity of innate-like γδT cells makes them valuable additions to current cancer immunotherapeutic concepts based on adaptive immunity, such as monoclonal antibodies and αβT cells. However, clinical success using γδT cells to treat cancer has so far fallen short.
Scheper, Wouter, Sebestyen, Zsolt, Kuball, Jürgen   +2 more
openaire   +3 more sources