Results 51 to 60 of about 1,803,893 (333)
Activation status of γδ T cells dictates their effect on osteoclast generation and bone resorption
Bone Reports, 2015 γδ T cells, a small subset of T cell population (5–10%), forms a bridge between innate and adaptive immunity. Although the role of γδ T cells in infectious diseases and antitumor immunity is well investigated, their role in bone biology needs to be ...
Swati P. Phalke, Shubhada V. Chiplunkar
doaj +1 more source
Journal of Extracellular Vesicles, 2023 γδ‐T cells are innate‐like T cells with dual antitumor activities. They can directly eradicate tumor cells and function as immunostimulatory cells to promote antitumor immunity.
Xiwei Wang +11 more
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OncoImmunology, 2022 Adoptive transfer of γδ T cells is a novel immunotherapeutic approach to glioblastoma. Few recent studies have shown the efficacy of γδ T cells against glioblastoma, but no previous studies have identified the ligand–receptor interactions between γδ T ...
Haeyoun Choi +9 more
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Cancer immunotherapy with γδ T cells: many paths ahead of us
Cellular & Molecular Immunology, 2020 γδ T cells play uniquely important roles in stress surveillance and immunity for infections and carcinogenesis. Human γδ T cells recognize and kill transformed cells independently of human leukocyte antigen (HLA) restriction, which is an essential ...
D. Kabelitz +4 more
semanticscholar +1 more source
Gut microbes, 2022 Gastrointestinal dysfunction is a common symptom of acute mountain sickness (AMS). The gut microbiota and γδ T cells play critical roles in intestinal disease.
Yuyu Li +8 more
semanticscholar +1 more source
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation [PDF]
Frontiers in Immunology, 2015 The contributions of γδ T-cells to immunity to infection or tumors critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells. These processes are molecularly controlled by surface receptors that capture key extracellular cues and convey downstream intracellular ...
Ribeiro, Sérgio T +2 more
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The co-stimulatory effects of MyD88-dependent Toll-like receptor signaling on activation of murine γδ T cells. [PDF]
PLoS ONE, 2014 γδ T cells express several different toll-like receptor (TLR)s. The role of MyD88- dependent TLR signaling in TCR activation of murine γδ T cells is incompletely defined. Here, we report that Pam3CSK4 (PAM, TLR2 agonist) and CL097 (TLR7 agonist), but not
Jinping Zhang +12 more
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Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells [PDF]
Frontiers in Immunology, 2014 Lymphocytes of the gamma delta (γδ) T-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. γδ T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoid cells.
Vasileios eBekiaris +3 more
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Skin γδ T Cells and Their Function in Wound Healing
Frontiers in Immunology, 2022 For the skin immune system, γδ T cells are important components, which help in defensing against damage and infection of skin. Compared to the conventional αβ T cells, γδ T cells have their own differentiation, development and activation characteristics.
Wengang Hu +7 more
semanticscholar +1 more source
Human Vδ2+ γδ T Cells Differentially Induce Maturation, Cytokine Production, and Alloreactive T Cell Stimulation by Dendritic Cells and B Cells [PDF]
Frontiers in Immunology, 2014 Human γδ T cells expressing the Vγ9Vδ2 T cell receptor can induce maturation of dendritic cells (DC) into antigen-presenting cells (APC) and B cells into antibody-secreting plasma cells. Since B cells are capable of presenting antigens to T cells, we investigated if Vγ9Vδ2 T cells can influence antigen-presentation by these cells. We report that Vγ9Vδ2
Doherty, Derek, Phelan, Andreea
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