Results 71 to 80 of about 1,803,893 (333)
γδ T Cells: The Ideal Tool for Cancer Immunotherapy
Cells, 2020 γδ T cells have recently gained considerable attention as an attractive tool for cancer adoptive immunotherapy due to their potent anti-tumor activity and unique role in immunosurveillance.
Mahboubeh Yazdanifar +3 more
semanticscholar +1 more source
A Highly Focused Antigen Receptor Repertoire Characterizes γδ T Cells That are Poised to Make IL-17 Rapidly in Naive Animals [PDF]
Frontiers in Immunology, 2015 Interleukin (IL)-17 plays a key role in immunity. In acute infections, a rapid IL-17 response must be induced without prior antigen exposure, and γδ T cells are the major initial IL-17 producers. In fact, some γδ T cells make IL-17 within hours after an immune challenge. These cells appear to acquire the ability to respond to IL-1 and IL-23 and to make
Yu-Ling eWei +8 more
openaire +3 more sources
The Dual Roles of Human γδ T Cells: Anti-Tumor or Tumor-Promoting
Frontiers in Immunology, 2021 γδ T cells are the unique T cell subgroup with their T cell receptors composed of γ chain and δ chain. Unlike αβ T cells, γδ T cells are non-MHC-restricted in recognizing tumor antigens, and therefore defined as innate immune cells.
Yang Li +4 more
semanticscholar +1 more source
Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro
, 2013 Peer ...
Thompson, K. +3 more
core +1 more source
γδ T cells take the stage [PDF]
, 2019 γδ T cells have been preserved alongside αβ T cells and B cells for ~500 million years of vertebrate evolution. γδ T cells are increasingly recognised as having important roles in immune responses to both microbial and non-microbial challenges in mice ...
Davey, MS +5 more
core +1 more source
, 2021 BACKGROUND Minimal residual disease (MRD) prior to allogeneic stem cell transplantation (allo-SCT) in AML is a poor risk factor for outcome. The γδ T cells represents a unique minority lymphocyte population which is preferentially located in ...
Evgeny Klyuchnikov +17 more
core +1 more source
Expanded Human Blood-Derived γδT Cells Display Potent Antigen-Presentation Functions [PDF]
Frontiers in Immunology, 2014 Cell-based immunotherapy strategies target tumors directly (via cytolytic effector cells) or aim at mobilizing endogenous anti-tumor immunity. The latter approach includes dendritic cells (DC) most frequently in the form of in vitro cultured peripheral blood monocytes-derived DC.
M. W. A. Khan +8 more
openaire +4 more sources
Human γδ T Cells Augment Antigen Presentation in Listeria Monocytogenes Infection
Molecular Medicine, 2016 Circulating γδ T cells In healthy Individuals rapidly respond to bacterial and viral pathogens. Many studies have demonstrated that γδ T cells are activated and expanded by Listeria monocytogenes (L.
Yuli Zhu +7 more
doaj +1 more source
A close look at current γδ T-cell immunotherapy
Frontiers in Immunology, 2023 Owing to their antitumor and major histocompatibility complex (MHC)-independent capacities, γδ T cells have gained popularity in adoptive T-cell immunotherapy in recent years. However, many unknowns still exist regarding γδ T cells, and few clinical data
Ling Ma +3 more
doaj +1 more source
Regulatory Role of Heat Shock Protein-specific T Cells in Host Defense [PDF]
, 1992 1992-03During infection with L.monocytogenes, a facultative intracellular bacteria, TcR γ/δ T cells specific for 65 kd hsp precede TcR α/β T cells specific for the listerial antigens in appearance.
YOSHIKAI, YASUNOBU
core +1 more source