Results 81 to 90 of about 1,803,893 (333)

Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the lifespan

Science immunology
During ontogeny, γδ T cells emerge from the thymus and directly seed peripheral tissues for in situ immunity. However, their functional role in humans has largely been defined from blood.
Joshua I. Gray, Daniel P. Caron, Steven B. Wells, Rebecca S Guyer, P. Szabo, Daniel B. Rainbow, Can Ergen, Ksenia Rybkina, Marissa C Bradley, Rei Matsumoto, K. Pethe, Masaru Kubota, Sarah A. Teichmann, Joanne L. Jones, N. Yosef, M. Atkinson, Maigan A. Brusko, T. Brusko, T. Connors, Peter A. Sims, D. Farber   +20 more
semanticscholar   +1 more source

Porcine γδ T cells express cytotoxic cell-associated markers and display killing activity but are not selectively cytotoxic against PRRSV- or swIAV-infected macrophages

Frontiers in Immunology
BackgroundGamma-delta (γδ) T cells are a major immune cell subset in pigs. Approximately 50% of circulating T cells are γδ T cells in young pigs and up to 30% in adult sows.
Leonie Bettin, Leonie Bettin, Joseph Darbellay, Jill van Kessel, Neeraj Dhar, Neeraj Dhar, Neeraj Dhar, Volker Gerdts, Volker Gerdts   +8 more
doaj   +1 more source

Obesity impairs γδ T cell homeostasis and antiviral function in humans. [PDF]

PLoS ONE, 2015
Obese patients are susceptible to increased morbidity and mortality associated with infectious diseases such as influenza A virus. γδ T cells and memory αβ T cells play key roles in reducing viral load by rapidly producing IFN-γ and lysing infected cells.
Anne E Costanzo, Kristen R Taylor, Shelley Dutt, Peggy P Han, Ken Fujioka, Julie M Jameson   +5 more
doaj   +1 more source

Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors.

, 2020
Downregulation of the T cell system has been proposed as a mechanism to block immunity in colonic cancer (CC). However, little has been studied about circulating αβ and γδ T cells and their immunological status in newly diagnosed patients.
Carlos García-Ballesteros, Carolina Hurtado, Juan Carlos Andreu-Ballester, Cuéllar Del Hoyo, María Del Carmen, Uribe, Natalia, Jiménez, Ana Isabel, Carmen Cuéllar, Francisca López-Chuliá, María Del Carmen Martín, Hidalgo-Coloma, Julia, Ana Isabel Jiménez, Hurtado, Carolina, Natalia Uribe, Llombart-Cussac, Antonio, Martín, María del Carmen, Andreu-Ballester, Juan Carlos, Antonio Llombart-Cussac, García-Ballesteros, Carlos, Lorena Galindo-Regal, López-Chuliá, Francisca, Julia Hidalgo-Coloma, Galindo-Regal, Lorena   +21 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Higher TIGIT+ γδ TCM cells may predict poor prognosis in younger adult patients with non-acute promyelocytic AML

Frontiers in Immunology
Introductionγδ T cells recognize and exert cytotoxicity against tumor cells. They are also considered potential immune cells for immunotherapy. Our previous study revealed that the altered expression of immune checkpoint T-cell immunoreceptor with ...
Qi Hou, Penglin Wang, Xueting Kong, Xueting Kong, Junjie Chen, Chao Yao, Xiaodan Luo, Yangqiu Li, Yangqiu Li, Zhenyi Jin, Zhenyi Jin, Xiuli Wu, Xiuli Wu   +12 more
doaj   +1 more source

Human γδ T cell Recognition of lipid A is predominately presented by CD1b or CD1c on dendritic cells

Biology Direct, 2009
Background The γδ T cells serve as early immune defense against certain encountered microbes. Only a few γδ T cell-recognized ligands from microbial antigens have been identified so far and the mechanisms by which γδ T cells recognize these ligands ...
He Wei, Cui Lianxian, Kang Lei, Cui Yongchun   +3 more
doaj   +1 more source

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue

Nature Metabolism, 2020
Ketone bodies are essential alternative fuels that allow humans to survive periods of glucose scarcity induced by starvation and prolonged exercise. A widely used ketogenic diet (KD), which is extremely high in fat with very low carbohydrates, drives the
Emily L. Goldberg, I. Shchukina, J. Asher, S. Sidorov, M. Artyomov, V. Dixit   +5 more
semanticscholar   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

γδ T Cells and B Cells

, 2017
γδ T cells constitute the third arm of a tripartite adaptive immune system in jawed vertebrates, besides αβ T cells and B cells. Like the other two lymphocyte-types, they express diverse antigen receptors, capable of specific ligand recognition ...
Huang, Yafei, Reinhardt, R Lee, Deming Sun, Rebecca L. O’Brien, Sun, Deming, Yafei Huang, R. Lee Reinhardt, Born, Willi K, Willi K. Born, Hua Huang, O’Brien, Rebecca L, Huang, Hua   +11 more
core   +1 more source