Results 91 to 100 of about 1,803,893 (333)

Roles of the adenosine receptor and CD73 in the regulatory effect of γδ T cells. [PDF]

, 2014
The adenosine A2A receptor (A2AR), the main functional adenosine receptor on murine T cells, plays a unique role in the attenuation of inflammation and tissue damage in vivo.
Deming Sun, Henry J. Kaplan, Hui Shao, Dongchun Liang, Chen, Mingjiazi, Shao, Hui, Liang, Dongchun, Mingjiazi Chen, Sun, Deming, Henry J Kaplan, Aijun Zuo, Kaplan, Henry J, Zuo, Aijun   +12 more
core   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

CD8+γδ T Cells Are More Frequent in CMV Seropositive Bone Marrow Grafts and Display Phenotype of an Adaptive Immune Response

Stem Cells International, 2019
The role of gamma delta (γδ) T cells in human cytomegalovirus (HCMV) immune surveillance has been the focus of research interest for years. Recent reports have shown a substantial clonal proliferation of γδ T cells in response to HCMV, shedding light on ...
Ahmed Gaballa, Lucas C. M. Arruda, Emelie Rådestad, Michael Uhlin   +3 more
doaj   +1 more source

Infliximab induces clonal expansion of γδ-T cells in Crohn's disease: a predictor of lymphoma risk? [PDF]

PLoS ONE, 2011
BackgroundConcominant with the widespread use of combined immunotherapy in the management of Crohn's disease (CD), the incidence of hepato-splenic gamma-delta (γδ)-T cell lymphoma has increased sharply in CD patients.
Jens Kelsen, Anders Dige, Heinrich Schwindt, Francesco D'Amore, Finn S Pedersen, Jørgen Agnholt, Lisbet A Christensen, Jens F Dahlerup, Christian L Hvas   +8 more
doaj   +1 more source

Selective recruitment of γδ T cells by a bispecific antibody for the treatment of acute myeloid leukemia

Leukemia, 2021
Despite significant progress over the last few decades in the treatment of acute myeloid leukemia (AML), there still remains a major unmet medical need for this disease.
R. Ganesan, Vijaykumar Chennupati, B. Ramachandran, M. Hansen, Sanjaya Singh, I. Grewal   +5 more
semanticscholar   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Human γδ T‐cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Clinical & Translational Immunology, 2019
Background Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T‐cell receptor (TCR) clonal expansions.
Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart I Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska   +19 more
doaj   +1 more source

Special features of γδ T cells in ruminants.

Molecular Immunology, 2021
Ruminant γδ T cells were discovered in the mid-1980's shortly after a novel T cell receptor (TCR) gene from murine cells was described in 1984 and the murine TCRγ gene locus in 1985.
C. Baldwin, P. Damani-Yokota, Alehgne Yirsaw, Kathleen Loonie, A. F. Teixeira, Alexandria Gillespie   +5 more
semanticscholar   +1 more source

‐17‐producing γδ T cells

, 2018
© 2018 Australasian Society for Immunology Inc.γδ T cells are an evolutionary conserved branch of the immune system and the first T cells to be generated in the developing mouse embryo.
Silva-Santos, Bruno, Bruno Silva‐Santos, Fiala, Gina, Gina J Fiala   +3 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source