Results 1 to 10 of about 30,987 (118)

A ligand-centered framework for γδ T cell activation in colorectal cancer revealed by single-cell and transformer-based perturbation [PDF]

Frontiers in Immunology
Understanding the activation mechanisms of γδ T cells in colorectal cancer (CRC) is critical for harnessing their therapeutic potential. Here, using an atlas of human CRC-infiltrating γδ T cells that we built by integrating multiple single-cell RNA-seq ...
Ran Ran, Douglas K. Brubaker, Douglas K. Brubaker   +2 more
doaj   +2 more sources

Metformin drives HIF-1α–mediated dual metabolic reprogramming to enhance γδ T cell therapy in triple-negative breast cancer [PDF]

Cancer Immunology, Immunotherapy
Triple-negative breast cancer (TNBC) lacks effective targeted treatments, rendering γδ T cell immunotherapy a promising therapeutic strategy. However, the function of these immune cells is often limited by exhaustion and immunosuppression.
Xuping Qin, Haowen Zhong, Meize Liu, Tiantian Yu, Rong Ma, Ying Zhou, Jingyu Chen, Fen Liu, Xiwei Wang, Jianting Long   +9 more
doaj   +2 more sources

Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]

PLoS ONE, 2018
Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Dongchun Liang, Jeong-Im Woo, Hui Shao, Willi K Born, Rebecca L O'Brien, Henry J Kaplan, Deming Sun   +6 more
doaj   +1 more source

Dissecting the cellular components of ex vivo γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trials

OncoImmunology, 2022
γδ T lymphocytes represent an emerging class of cellular immunotherapy with preclinical promise to treat cancer, notably neuroblastoma. The innate-like immune cell subset demonstrates inherent cytoxicity toward tumor cells independent of MHC recognition,
Hunter C. Jonus, Rebecca E. Burnham, Andrew Ho, Adeiye A. Pilgrim, Jenny Shim, Christopher B. Doering, H. Trent Spencer, Kelly C. Goldsmith   +7 more
doaj   +1 more source

Infliximab induces clonal expansion of γδ-T cells in Crohn's disease: a predictor of lymphoma risk? [PDF]

PLoS ONE, 2011
BackgroundConcominant with the widespread use of combined immunotherapy in the management of Crohn's disease (CD), the incidence of hepato-splenic gamma-delta (γδ)-T cell lymphoma has increased sharply in CD patients.
Jens Kelsen, Anders Dige, Heinrich Schwindt, Francesco D'Amore, Finn S Pedersen, Jørgen Agnholt, Lisbet A Christensen, Jens F Dahlerup, Christian L Hvas   +8 more
doaj   +1 more source

γδ T cells: origin and fate, subsets, diseases and immunotherapy

Signal Transduction and Targeted Therapy, 2023
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune renormalization as a promising strategy in disease treatment.
Yi Hu, Qinglin Hu, Yongsheng Li, Ligong Lu, Zheng Xiang, Zhinan Yin, Dieter Kabelitz, Yangzhe Wu   +7 more
doaj   +1 more source

Two Distinct Mechanisms Underlying γδ T Cell-Mediated Regulation of Collagen Type I in Lung Fibroblasts

Cells, 2022
Idiopathic pulmonary fibrosis is a chronic intractable lung disease, leading to respiratory failure and death. Although anti-fibrotic agents delay disease progression, they are not considered curative treatments, and alternative modalities have attracted
Daisuke Okuno, Noriho Sakamoto, Yoshiko Akiyama, Takatomo Tokito, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Yuji Ishimatsu, Mohammed S. O. Tagod, Haruki Okamura, Yoshimasa Tanaka, Hiroshi Mukae   +11 more
doaj   +1 more source

Characterization of Adaptive-like γδ T Cells in Ugandan Infants during Primary Cytomegalovirus Infection

Viruses, 2021
Gamma-delta (γδ) T cells are unconventional T cells that help control cytomegalovirus (CMV) infection in adults. γδ T cells develop early in gestation, and a fetal public γδ T cell receptor (TCR) clonotype is detected in congenital CMV infections ...
Jessica Tuengel, Sanya Ranchal, Alexandra Maslova, Gurpreet Aulakh, Maria Papadopoulou, Sibyl Drissler, Bing Cai, Cetare Mohsenzadeh-Green, Hugo Soudeyns, Sara Mostafavi, Peter van den Elzen, David Vermijlen, Laura Cook, Soren Gantt   +13 more
doaj   +1 more source

Intracellular radar: Understanding γδ T cell immune surveillance and implications for clinical strategies in oncology

Frontiers in Oncology, 2022
T cells play a key role in anticancer immunity, with responses mediated through a diversity of αβ or γδ T cell receptors. Although αβ and γδ T cells stem from common thymic precursors, the development and subsequent biological roles of these two subsets ...
Anne B. C. Cherry, Nicholas A. Gherardin, Hafiz I. Sikder   +2 more
doaj   +1 more source

Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy

Frontiers in Medicine, 2020
Gamma delta (γδ) T cells recently emerged as an attractive candidate for cancer immunotherapy treatments due to their inherent cytotoxicity against both hematological and solid tumors.
Rebecca E. Burnham, Rebecca E. Burnham, Jaquelyn T. Zoine, Jaquelyn T. Zoine, Jamie Y. Story, Jamie Y. Story, Swetha N. Garimalla, Greg Gibson, Aaron Rae, Erich Williams, Lisa Bixby, David Archer, Christopher B. Doering, H. Trent Spencer   +13 more
doaj   +1 more source