γδ T cell mediated immune responses in Disease and Therapy [PDF]
Frontiers in Immunology, 2014 The role of γδ T cells in immunotherapy has gained specific importance in the recent years because of their prominent function involving directly or indirectly in the rehabilitation of the diseases. γδ T cells represent a minor population of T cells that
Sree Latha eT +6 more
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Generation and first characterization of TRDC-knockout pigs lacking γδ T cells [PDF]
Scientific Reports, 2021 The TRDC-locus encodes the T cell receptor delta constant region, one component of the γδ T cell receptor which is essential for development of γδ T cells.
Bjoern Petersen +9 more
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Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells
Cell Reports, 2017 Summary: Despite a growing appreciation of γδ T cell contributions to numerous immune responses, the mechanisms that underpin their thymic development remain poorly understood. Here, using precursor/product relationships, we identify thymic stages in two
Nital Sumaria +3 more
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Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus [PDF]
Frontiers in Immunology, 2019 Here we investigate the function of Hedgehog (Hh) signaling in thymic γδ T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signaling promotes γδ T-cell development in the thymus and influences γδ T-cell effector subset ...
Konstantinos Mengrelis +8 more
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The transcription factor PU.1 regulates γδ T cell homeostasis.
PLoS ONE, 2011 BackgroundT cell development results in the generation of both mature αβ and γδ T cells. While αβ T cells predominate in secondary lymphoid organs, γδ T cells are more abundant in mucosal tissues. PU.1, an Ets family transcription factor, also identified
Rukhsana Jabeen +4 more
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PLoS ONE, 2019 Using induced pluripotent stem cells (iPSCs) to derive chimeric antigen receptor-modified T (CAR-T) cells has great industrial potential. A previous study used αβ T cell-derived CAR-modified iPSCs to produce CAR-T cells.
Jieming Zeng, Shin Yi Tang, Shu Wang
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Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner. [PDF]
, 2023 Immune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity.
Blankenhaus, Birte +27 more
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Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity [PDF]
, 2021 The γδ T cell immune cell lineage has remained relatively enigmatic and under-characterised since their identification. Conversely, the insights we have, highlight their central importance in diverse immunological roles and homeostasis.
Davey, MS +5 more
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Monitoring Circulating γδ T Cells in Cancer Patients to Optimize γδ T Cell-Based Immunotherapy [PDF]
Frontiers in Immunology, 2014 The success of γδ T cell-based immunotherapy, where the cytotoxic activity of circulating γδ T lymphocytes is activated by nitrogen-containing bisphosphonates (n-BP), or possibly by bispecific antibodies or the combination of both, requires a profound knowledge of patients' γδ T cells.
Oberg, Hans-Heinrich +7 more
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An increased number of circulating γ/δ TCR + T cells in patients with chronic viral hepatitis [PDF]
FEMS Immunology & Medical Microbiology, 1995 Abstract There is evidence that γ δ TCR + T cells are specialized in recognizing different antigens, but their immunologic role as a second TCR is still unclear. The aim of this study was to investigate the percentage and absolute numbers of circulating γ δ TCR + T cells in patients with chronic viral hepatitis (CVH) and to compare with
Vassiliki Nikolopoulou +4 more
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