Results 11 to 20 of about 4,401,008 (278)

γδ T cell mediated immune responses in Disease and Therapy [PDF]

Frontiers in Immunology, 2014
The role of γδ T cells in immunotherapy has gained specific importance in the recent years because of their prominent function involving directly or indirectly in the rehabilitation of the diseases. γδ T cells represent a minor population of T cells that
Sree Latha eT, Madhava C Reddy, Prasad Vijaya Raghava Durbaka, Aparna eRachamallu, Pallu eReddanna, Pallu eReddanna, Dakshayani eLomada   +6 more
doaj   +3 more sources

Monitoring Circulating γδ T Cells in Cancer Patients to Optimize γδ T Cell-Based Immunotherapy [PDF]

Frontiers in Immunology, 2014
The success of γδ T cell-based immunotherapy, where the cytotoxic activity of circulating γδ T lymphocytes is activated by nitrogen-containing bisphosphonates (n-BP), or possibly by bispecific antibodies or the combination of both, requires a profound knowledge of patients' γδ T cells.
Oberg, Hans-Heinrich, Kellner, Christian, Peipp, Matthias, Sebens, Susanne, Adam-Klages, Sabine, Gramatzki, Martin, Kabelitz, Dieter, Wesch, Daniela   +7 more
openaire   +2 more sources

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions. [PDF]

, 2017
T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo ...
Coles, Marc, Debes, Gudrun F., Detmar, Michael, Frei, Thomas, Halin, Cornelia, Hunter, Morgan C., Melero, Ignacio, Proulx, Steven T, Rouzaut, Ana, Russo, Erica, Teijeira, Alvaro   +10 more
core   +6 more sources

An increased number of circulating γ/δ TCR + T cells in patients with chronic viral hepatitis [PDF]

FEMS Immunology & Medical Microbiology, 1995
Abstract There is evidence that γ δ TCR + T cells are specialized in recognizing different antigens, but their immunologic role as a second TCR is still unclear. The aim of this study was to investigate the percentage and absolute numbers of circulating γ δ TCR + T cells in patients with chronic viral hepatitis (CVH) and to compare with
Vassiliki Nikolopoulou, Athanasios Skoutelis, Konstantinos Thomopoulos, Bassam Salsaa, Nicholas Zoumbos   +4 more
openaire   +1 more source

Intracellular radar: Understanding γδ T cell immune surveillance and implications for clinical strategies in oncology

Frontiers in Oncology, 2022
T cells play a key role in anticancer immunity, with responses mediated through a diversity of αβ or γδ T cell receptors. Although αβ and γδ T cells stem from common thymic precursors, the development and subsequent biological roles of these two subsets ...
Anne B. C. Cherry, Nicholas A. Gherardin, Hafiz I. Sikder   +2 more
doaj   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source

A close look at current γδ T-cell immunotherapy

Frontiers in Immunology, 2023
Owing to their antitumor and major histocompatibility complex (MHC)-independent capacities, γδ T cells have gained popularity in adoptive T-cell immunotherapy in recent years. However, many unknowns still exist regarding γδ T cells, and few clinical data
Ling Ma, Ling Ma, Yanmin Feng, Zishan Zhou   +3 more
doaj   +1 more source

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

Journal of Experimental Medicine, 2020
T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR–mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to
Sarah C. Edwards, Caroline E. Sutton, Kristin Ladell, Emma J. Grant, James E. McLaren, Fiona Roche, Pradyot Dash, Nopporn Apiwattanakul, Walid Awad, Kelly L. Miners, Stephen J. Lalor, Julie C. Ribot, Song Baik, Barry Moran, Aoife McGinley, Valerie Pivorunas, Lori Dowding, Michael Macoritto, Jesus Paez-Cortez, Anthony Slavin, Graham Anderson, Bruno Silva-Santos, Karsten Hokamp, David A. Price, Paul G. Thomas, Rachel M. McLoughlin, Kingston H.G. Mills   +26 more
openaire   +4 more sources

Plasticity of γδ T Cells: Impact on the Anti-Tumor Response [PDF]

Frontiers in Immunology, 2014
The tumor immune microenvironment contributes to tumor initiation, progression, and response to therapy. Among the immune cell subsets that play a role in the tumor microenvironment, innate-like T cells that express T cell receptors composed of γ and δ chains (γδ T cells) are of particular interest.
Lafont, Virginie, Sanchez, Françoise, Laprevotte, Emilie, Michaud, Henri-Alexandre, Gros, Laurent, Eliaou, Jean-François, Bonnefoy, Nathalie   +6 more
openaire   +2 more sources

Characterization of Adaptive-like γδ T Cells in Ugandan Infants during Primary Cytomegalovirus Infection

Viruses, 2021
Gamma-delta (γδ) T cells are unconventional T cells that help control cytomegalovirus (CMV) infection in adults. γδ T cells develop early in gestation, and a fetal public γδ T cell receptor (TCR) clonotype is detected in congenital CMV infections ...
Jessica Tuengel, Sanya Ranchal, Alexandra Maslova, Gurpreet Aulakh, Maria Papadopoulou, Sibyl Drissler, Bing Cai, Cetare Mohsenzadeh-Green, Hugo Soudeyns, Sara Mostafavi, Peter van den Elzen, David Vermijlen, Laura Cook, Soren Gantt   +13 more
doaj   +1 more source