Results 11 to 20 of about 31,118 (247)

γδ T cell mediated immune responses in Disease and Therapy [PDF]

Frontiers in Immunology, 2014
The role of γδ T cells in immunotherapy has gained specific importance in the recent years because of their prominent function involving directly or indirectly in the rehabilitation of the diseases. γδ T cells represent a minor population of T cells that
Sree Latha eT, Madhava C Reddy, Prasad Vijaya Raghava Durbaka, Aparna eRachamallu, Pallu eReddanna, Pallu eReddanna, Dakshayani eLomada   +6 more
doaj   +3 more sources

Human Peripheral CD4+ Vδ1+ γδT Cells Can Develop into αβT Cells [PDF]

Frontiers in Immunology, 2014
The lifelong generation of αβT cells enables us to continuously build immunity against pathogens and malignancies despite the loss of thymic function with age. Homeostatic proliferation of post-thymic naïve and memory T cells and their transition into effector and long-lived memory cells balance the decreasing output of naïve T cells, and recent ...
Ziegler, Hendrik, Welker, Christian, Sterk, Marco, Haarer, Jan, Rammensee, Hans-Georg, Handgretinger, Rupert, Schilbach, Karin   +6 more
openaire   +2 more sources

An increased number of circulating γ/δ TCR + T cells in patients with chronic viral hepatitis [PDF]

FEMS Immunology & Medical Microbiology, 1995
Abstract There is evidence that γ δ TCR + T cells are specialized in recognizing different antigens, but their immunologic role as a second TCR is still unclear. The aim of this study was to investigate the percentage and absolute numbers of circulating γ δ TCR + T cells in patients with chronic viral hepatitis (CVH) and to compare with
Vassiliki Nikolopoulou, Athanasios Skoutelis, Konstantinos Thomopoulos, Bassam Salsaa, Nicholas Zoumbos   +4 more
openaire   +1 more source

Monitoring Circulating γδ T Cells in Cancer Patients to Optimize γδ T Cell-Based Immunotherapy [PDF]

Frontiers in Immunology, 2014
The success of γδ T cell-based immunotherapy, where the cytotoxic activity of circulating γδ T lymphocytes is activated by nitrogen-containing bisphosphonates (n-BP), or possibly by bispecific antibodies or the combination of both, requires a profound knowledge of patients' γδ T cells.
Oberg, Hans-Heinrich, Kellner, Christian, Peipp, Matthias, Sebens, Susanne, Adam-Klages, Sabine, Gramatzki, Martin, Kabelitz, Dieter, Wesch, Daniela   +7 more
openaire   +3 more sources

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

Journal of Experimental Medicine, 2020
T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR–mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to
Sarah C. Edwards, Caroline E. Sutton, Kristin Ladell, Emma J. Grant, James E. McLaren, Fiona Roche, Pradyot Dash, Nopporn Apiwattanakul, Walid Awad, Kelly L. Miners, Stephen J. Lalor, Julie C. Ribot, Song Baik, Barry Moran, Aoife McGinley, Valerie Pivorunas, Lori Dowding, Michael Macoritto, Jesus Paez-Cortez, Anthony Slavin, Graham Anderson, Bruno Silva-Santos, Karsten Hokamp, David A. Price, Paul G. Thomas, Rachel M. McLoughlin, Kingston H.G. Mills   +26 more
openaire   +4 more sources

Plasticity of γδ T Cells: Impact on the Anti-Tumor Response [PDF]

Frontiers in Immunology, 2014
The tumor immune microenvironment contributes to tumor initiation, progression, and response to therapy. Among the immune cell subsets that play a role in the tumor microenvironment, innate-like T cells that express T cell receptors composed of γ and δ chains (γδ T cells) are of particular interest.
Lafont, Virginie, Sanchez, Françoise, Laprevotte, Emilie, Michaud, Henri-Alexandre, Gros, Laurent, Eliaou, Jean-François, Bonnefoy, Nathalie   +6 more
openaire   +2 more sources

γδ T Lymphocytes in the Diagnosis of Human T Cell Receptor Immunodeficiencies [PDF]

Frontiers in Immunology, 2015
Human T cell receptor (TCR) immunodeficiencies (TCRID) are rare autosomal recessive disorders caused by mutations affecting TCR, CD3, or CD247 chains, which share developmental, functional, and TCR expression defects (1). Their rapid diagnosis is fundamental for patient survival and early hematopoietic stemcell transplantation.Here,we propose that ...
Garcillan, B, Marin, AVM, Jimenez-Reinoso, A, Briones, AC, Munoz-Ruiz, M, Garcia-Leon, MJ, Gil, J, Allende, LM, Martinez-Naves, E, Toribio, ML, Regueiro, JR   +10 more
openaire   +6 more sources

A close look at current γδ T-cell immunotherapy

Frontiers in Immunology, 2023
Owing to their antitumor and major histocompatibility complex (MHC)-independent capacities, γδ T cells have gained popularity in adoptive T-cell immunotherapy in recent years. However, many unknowns still exist regarding γδ T cells, and few clinical data
Ling Ma, Ling Ma, Yanmin Feng, Zishan Zhou   +3 more
doaj   +1 more source

γδ T Cells in HIV Disease: Past, Present, and Future [PDF]

Frontiers in Immunology, 2015
Human immunodeficiency virus (HIV) type 1 dysregulates γδ T cells as part of an immune evasion mechanism. Nearly three decades of research defined the effects of HIV on γδ T cells and how this impacts disease. With highly effective antiretroviral therapy providing virus suppression and longer survival, we expected a return to normal for γδ T cells ...
Pauza, C. David, Poonia, Bhawna, Li, Haishan, Cairo, Cristiana, Chaudhry, Suchita   +4 more
openaire   +3 more sources

Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus

Frontiers in Immunology, 2019
Here we investigate the function of Hedgehog (Hh) signaling in thymic γδ T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signaling promotes γδ T-cell development in the thymus and influences γδ T-cell effector subset ...
Konstantinos Mengrelis, Ching-In Lau, Jasmine Rowell, Anisha Solanki, Sonia Norris, Susan Ross, Masahiro Ono, Susan Outram, Tessa Crompton   +8 more
doaj   +1 more source