Results 21 to 30 of about 33,979 (285)

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

Journal of Experimental Medicine, 2020
T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR–mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to
Sarah C. Edwards, Caroline E. Sutton, Kristin Ladell, Emma J. Grant, James E. McLaren, Fiona Roche, Pradyot Dash, Nopporn Apiwattanakul, Walid Awad, Kelly L. Miners, Stephen J. Lalor, Julie C. Ribot, Song Baik, Barry Moran, Aoife McGinley, Valerie Pivorunas, Lori Dowding, Michael Macoritto, Jesus Paez-Cortez, Anthony Slavin, Graham Anderson, Bruno Silva-Santos, Karsten Hokamp, David A. Price, Paul G. Thomas, Rachel M. McLoughlin, Kingston H.G. Mills   +26 more
openaire   +4 more sources

Plasticity of γδ T Cells: Impact on the Anti-Tumor Response [PDF]

Frontiers in Immunology, 2014
The tumor immune microenvironment contributes to tumor initiation, progression, and response to therapy. Among the immune cell subsets that play a role in the tumor microenvironment, innate-like T cells that express T cell receptors composed of γ and δ chains (γδ T cells) are of particular interest.
Lafont, Virginie, Sanchez, Françoise, Laprevotte, Emilie, Michaud, Henri-Alexandre, Gros, Laurent, Eliaou, Jean-François, Bonnefoy, Nathalie   +6 more
openaire   +2 more sources

γδ T Lymphocytes in the Diagnosis of Human T Cell Receptor Immunodeficiencies [PDF]

Frontiers in Immunology, 2015
Human T cell receptor (TCR) immunodeficiencies (TCRID) are rare autosomal recessive disorders caused by mutations affecting TCR, CD3, or CD247 chains, which share developmental, functional, and TCR expression defects (1). Their rapid diagnosis is fundamental for patient survival and early hematopoietic stemcell transplantation.Here,we propose that ...
Garcillan, B, Marin, AVM, Jimenez-Reinoso, A, Briones, AC, Munoz-Ruiz, M, Garcia-Leon, MJ, Gil, J, Allende, LM, Martinez-Naves, E, Toribio, ML, Regueiro, JR   +10 more
openaire   +7 more sources

Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy

Frontiers in Medicine, 2020
Gamma delta (γδ) T cells recently emerged as an attractive candidate for cancer immunotherapy treatments due to their inherent cytotoxicity against both hematological and solid tumors.
Rebecca E. Burnham, Rebecca E. Burnham, Jaquelyn T. Zoine, Jaquelyn T. Zoine, Jamie Y. Story, Jamie Y. Story, Swetha N. Garimalla, Greg Gibson, Aaron Rae, Erich Williams, Lisa Bixby, David Archer, Christopher B. Doering, H. Trent Spencer   +13 more
doaj   +1 more source

The Jekyll and Hyde story of IL17-Producing γδT Cells [PDF]

Frontiers in Immunology, 2015
In comparison to conventional αβT cells, γδT cells are considered as specialized T cells based on their contributions in regulating immune response. γδT cells sense early environmental signals and initiate local immune-surveillance. The development of functional subtypes of γδT cells takes place in the thymus but they also exhibit plasticity in ...
Patil, Rushikesh S., Bhat, Sajad A., Dar, Asif A., Chiplunkar, Shubhada V.   +3 more
openaire   +2 more sources

A close look at current γδ T-cell immunotherapy

Frontiers in Immunology, 2023
Owing to their antitumor and major histocompatibility complex (MHC)-independent capacities, γδ T cells have gained popularity in adoptive T-cell immunotherapy in recent years. However, many unknowns still exist regarding γδ T cells, and few clinical data
Ling Ma, Ling Ma, Yanmin Feng, Zishan Zhou   +3 more
doaj   +1 more source

γδ T Cells in HIV Disease: Past, Present, and Future [PDF]

Frontiers in Immunology, 2015
Human immunodeficiency virus (HIV) type 1 dysregulates γδ T cells as part of an immune evasion mechanism. Nearly three decades of research defined the effects of HIV on γδ T cells and how this impacts disease. With highly effective antiretroviral therapy providing virus suppression and longer survival, we expected a return to normal for γδ T cells ...
Pauza, C. David, Poonia, Bhawna, Li, Haishan, Cairo, Cristiana, Chaudhry, Suchita   +4 more
openaire   +3 more sources

Exosomes derived from γδ-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment

Journal for ImmunoTherapy of Cancer, 2022
Background Radiotherapy is the first-line treatment for patients nasopharyngeal carcinoma (NPC), but its therapeutic efficacy is poor in some patients due to radioresistance.
Godfrey Chi-fung Chan, Xiwei Wang, Yanmei Zhang, Xiaofeng Mu, Chloe Ran Tu, Yuet Chung, Sai Wah Tsao, Wing-Hang Leung, Yu-lung Lau, Yinping Liu, Wenwei Tu   +10 more
doaj   +1 more source

γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation. [PDF]

PLoS ONE, 2013
Both antigen recognition and CD28 costimulation are required for the activation of naïve αβ T cells and their subsequent differentiation into cytokine-producing or cytotoxic effectors.
Renee M Laird, Benjamin J Wolf, Michael F Princiotta, Sandra M Hayes   +3 more
doaj   +1 more source

γδ T cells as early sensors of tissue damage and mediators of secondary neurodegeneration [PDF]

Frontiers in Cellular Neuroscience, 2014
Spontaneous or medically induced reperfusion occurs in up to 70% of patients within 24 h after cerebral ischemia. Reperfusion of ischemic brain tissue can augment the inflammatory response that causes additional injury. Recently, T cells have been shown to be an essential part of the post-ischemic tissue damage, and especially IL-17 secreting T cells ...
Gelderblom, Mathias, Arunachalam, Priyadharshini, Magnus, Tim   +2 more
openaire   +3 more sources