Results 21 to 30 of about 4,401,008 (278)

Multiple Receptor-Ligand Interactions Direct Tissue-Resident γδ T Cell Activation [PDF]

Frontiers in Immunology, 2014
γδ T cells represent a major T cell population in epithelial tissues, such as skin, intestine, and lung, where they function in maintenance of the epithelium and provide a crucial first line defense against environmental and pathogenic insults. Despite their importance, the molecular mechanisms directing their activation and function have remained ...
Witherden, Deborah. A., Ramirez, Kevin, Havran, Wendy L.   +2 more
openaire   +2 more sources

Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy

Frontiers in Medicine, 2020
Gamma delta (γδ) T cells recently emerged as an attractive candidate for cancer immunotherapy treatments due to their inherent cytotoxicity against both hematological and solid tumors.
Rebecca E. Burnham, Rebecca E. Burnham, Jaquelyn T. Zoine, Jaquelyn T. Zoine, Jamie Y. Story, Jamie Y. Story, Swetha N. Garimalla, Greg Gibson, Aaron Rae, Erich Williams, Lisa Bixby, David Archer, Christopher B. Doering, H. Trent Spencer   +13 more
doaj   +1 more source

γδ T Cells in HIV Disease: Past, Present, and Future [PDF]

Frontiers in Immunology, 2015
Human immunodeficiency virus (HIV) type 1 dysregulates γδ T cells as part of an immune evasion mechanism. Nearly three decades of research defined the effects of HIV on γδ T cells and how this impacts disease. With highly effective antiretroviral therapy providing virus suppression and longer survival, we expected a return to normal for γδ T cells ...
Pauza, C. David, Poonia, Bhawna, Li, Haishan, Cairo, Cristiana, Chaudhry, Suchita   +4 more
openaire   +3 more sources

Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus

Frontiers in Immunology, 2019
Here we investigate the function of Hedgehog (Hh) signaling in thymic γδ T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signaling promotes γδ T-cell development in the thymus and influences γδ T-cell effector subset ...
Konstantinos Mengrelis, Ching-In Lau, Jasmine Rowell, Anisha Solanki, Sonia Norris, Susan Ross, Masahiro Ono, Susan Outram, Tessa Crompton   +8 more
doaj   +1 more source

Exosomes derived from γδ-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment

Journal for ImmunoTherapy of Cancer, 2022
Background Radiotherapy is the first-line treatment for patients nasopharyngeal carcinoma (NPC), but its therapeutic efficacy is poor in some patients due to radioresistance.
Godfrey Chi-fung Chan, Xiwei Wang, Yanmei Zhang, Xiaofeng Mu, Chloe Ran Tu, Yuet Chung, Sai Wah Tsao, Wing-Hang Leung, Yu-lung Lau, Yinping Liu, Wenwei Tu   +10 more
doaj   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
Alexander-Miller, Almeida, Appay, Berger, Betts, Bosselut, Cerundolo, Gallimore, Gorman, Hansen, Hollander, Homann, Jelley-Gibbs, Jenkins, Jones, Jones, Judge, Karrer, Kattan, Kedzierska, Kim, Kohlmeier, Lefranc, Liang, Moffat, Neveu, Norbury, Powell, Price, Quigley, Rangel-Moreno, Richards, Roberts, Schluns, Tan, Tough, Trautmann, Valkenburg, Valkenburg, Woodland, Wooldridge, Zammit   +41 more
core   +1 more source

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]

, 2019
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua, Fetcko, Kaleigh, Henriquez, Mario, Huff, Wei X., Kwon, Jae Hyun   +4 more
core   +1 more source

γδ T Lymphocytes in the Diagnosis of Human T Cell Receptor Immunodeficiencies [PDF]

Frontiers in Immunology, 2015
Human T cell receptor (TCR) immunodeficiencies (TCRID) are rare autosomal recessive disorders caused by mutations affecting TCR, CD3, or CD247 chains, which share developmental, functional, and TCR expression defects (1). Their rapid diagnosis is fundamental for patient survival and early hematopoietic stemcell transplantation.Here,we propose that ...
Garcillan, B, Marin, AVM, Jimenez-Reinoso, A, Briones, AC, Munoz-Ruiz, M, Garcia-Leon, MJ, Gil, J, Allende, LM, Martinez-Naves, E, Toribio, ML, Regueiro, JR   +10 more
openaire   +7 more sources

Potential Use of γδ T Cell-Based Vaccines in Cancer Immunotherapy [PDF]

Frontiers in Immunology, 2014
IMMUNOTHERAPY IS A FAST ADVANCING METHODOLOGY INVOLVING ONE OF TWO APPROACHES: (1) compounds targeting immune checkpoints and (2) cellular immunomodulators. The latter approach is still largely experimental and features in vitro generated, live immune effector cells, or antigen-presenting cells.
Khan, Mohd Wajid A., Eberl, Matthias, Moser, Bernhard   +2 more
openaire   +3 more sources

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells

Cell Reports, 2017
Summary: Despite a growing appreciation of γδ T cell contributions to numerous immune responses, the mechanisms that underpin their thymic development remain poorly understood. Here, using precursor/product relationships, we identify thymic stages in two
Nital Sumaria, Capucine L. Grandjean, Bruno Silva-Santos, Daniel J. Pennington   +3 more
doaj   +1 more source