Results 21 to 30 of about 31,118 (247)

The Jekyll and Hyde story of IL17-Producing γδT Cells [PDF]

Frontiers in Immunology, 2015
In comparison to conventional αβT cells, γδT cells are considered as specialized T cells based on their contributions in regulating immune response. γδT cells sense early environmental signals and initiate local immune-surveillance. The development of functional subtypes of γδT cells takes place in the thymus but they also exhibit plasticity in ...
Patil, Rushikesh S., Bhat, Sajad A., Dar, Asif A., Chiplunkar, Shubhada V.   +3 more
openaire   +2 more sources

γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation. [PDF]

PLoS ONE, 2013
Both antigen recognition and CD28 costimulation are required for the activation of naïve αβ T cells and their subsequent differentiation into cytokine-producing or cytotoxic effectors.
Renee M Laird, Benjamin J Wolf, Michael F Princiotta, Sandra M Hayes   +3 more
doaj   +1 more source

Exosomes derived from γδ-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment

Journal for ImmunoTherapy of Cancer, 2022
Background Radiotherapy is the first-line treatment for patients nasopharyngeal carcinoma (NPC), but its therapeutic efficacy is poor in some patients due to radioresistance.
Godfrey Chi-fung Chan, Xiwei Wang, Yanmei Zhang, Xiaofeng Mu, Chloe Ran Tu, Yuet Chung, Sai Wah Tsao, Wing-Hang Leung, Yu-lung Lau, Yinping Liu, Wenwei Tu   +10 more
doaj   +1 more source

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells

Cell Reports, 2017
Summary: Despite a growing appreciation of γδ T cell contributions to numerous immune responses, the mechanisms that underpin their thymic development remain poorly understood. Here, using precursor/product relationships, we identify thymic stages in two
Nital Sumaria, Capucine L. Grandjean, Bruno Silva-Santos, Daniel J. Pennington   +3 more
doaj   +1 more source

γδ T cells as early sensors of tissue damage and mediators of secondary neurodegeneration [PDF]

Frontiers in Cellular Neuroscience, 2014
Spontaneous or medically induced reperfusion occurs in up to 70% of patients within 24 h after cerebral ischemia. Reperfusion of ischemic brain tissue can augment the inflammatory response that causes additional injury. Recently, T cells have been shown to be an essential part of the post-ischemic tissue damage, and especially IL-17 secreting T cells ...
Gelderblom, Mathias, Arunachalam, Priyadharshini, Magnus, Tim   +2 more
openaire   +3 more sources

Potential Use of γδ T Cell-Based Vaccines in Cancer Immunotherapy [PDF]

Frontiers in Immunology, 2014
IMMUNOTHERAPY IS A FAST ADVANCING METHODOLOGY INVOLVING ONE OF TWO APPROACHES: (1) compounds targeting immune checkpoints and (2) cellular immunomodulators. The latter approach is still largely experimental and features in vitro generated, live immune effector cells, or antigen-presenting cells.
Khan, Mohd Wajid A., Eberl, Matthias, Moser, Bernhard   +2 more
openaire   +3 more sources

Generation and first characterization of TRDC-knockout pigs lacking γδ T cells

Scientific Reports, 2021
The TRDC-locus encodes the T cell receptor delta constant region, one component of the γδ T cell receptor which is essential for development of γδ T cells.
Bjoern Petersen, Robert Kammerer, Antje Frenzel, Petra Hassel, Tung Huy Dau, Roswitha Becker, Angele Breithaupt, Reiner Georg Ulrich, Andrea Lucas-Hahn, Gregor Meyers   +9 more
doaj   +1 more source

Multiple Receptor-Ligand Interactions Direct Tissue-Resident γδ T Cell Activation [PDF]

Frontiers in Immunology, 2014
γδ T cells represent a major T cell population in epithelial tissues, such as skin, intestine, and lung, where they function in maintenance of the epithelium and provide a crucial first line defense against environmental and pathogenic insults. Despite their importance, the molecular mechanisms directing their activation and function have remained ...
Witherden, Deborah. A., Ramirez, Kevin, Havran, Wendy L.   +2 more
openaire   +2 more sources

Obesity impairs γδ T cell homeostasis and antiviral function in humans. [PDF]

PLoS ONE, 2015
Obese patients are susceptible to increased morbidity and mortality associated with infectious diseases such as influenza A virus. γδ T cells and memory αβ T cells play key roles in reducing viral load by rapidly producing IFN-γ and lysing infected cells.
Anne E Costanzo, Kristen R Taylor, Shelley Dutt, Peggy P Han, Ken Fujioka, Julie M Jameson   +5 more
doaj   +1 more source

Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation [PDF]

Frontiers in Immunology, 2015
Despite effective anti-viral therapies, cytomegalovirus (CMV) is still associated with direct (CMV disease) and indirect effects (rejection and poor graft survival) in kidney transplant recipients. Recently, an unconventional T cell population (collectively designated as Vδ2(neg) γδ T cells) has been characterized during the anti-CMV immune response in
Couzi, Lionel, Pitard, Vincent, Moreau, Jean-François, Merville, Pierre, Déchanet-Merville, Julie   +4 more
openaire   +2 more sources