Results 31 to 40 of about 33,979 (285)

TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer.

, 2021
Despite its role in cancer surveillance, adoptive immunotherapy using γδ T cells has achieved limited efficacy. To enhance trafficking to bone marrow, circulating Vγ9Vδ2 T cells are expanded in serum-free medium containing TGF-β1 and IL-2 (γδ[T2] cells ...
Martinez, O, Xie, J, Győrffy, B, Joseph, C-YR, de Rosales, RTM, Zabinski, T, Hull, C, Hardiman, T, Taylor, CA, Davies, DM, Draper, B, Tutt, ANJ, Whilding, LM, Achkova, D, Hess-Stumpp, H, Adami, A, Aswad, F, Grigoriadis, A, Cozzetto, D, Maher, J, Obajdin, J, Roider, HG, Luu Hoang, KN, Iqbal, A, Ciprut, S, Man, F, Halim, L, Parente-Pereira, AC, Sommer, A, Beatson, RE, Quist, J   +30 more
core   +1 more source

Potential Use of γδ T Cell-Based Vaccines in Cancer Immunotherapy [PDF]

Frontiers in Immunology, 2014
IMMUNOTHERAPY IS A FAST ADVANCING METHODOLOGY INVOLVING ONE OF TWO APPROACHES: (1) compounds targeting immune checkpoints and (2) cellular immunomodulators. The latter approach is still largely experimental and features in vitro generated, live immune effector cells, or antigen-presenting cells.
Khan, Mohd Wajid A., Eberl, Matthias, Moser, Bernhard   +2 more
openaire   +3 more sources

Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation [PDF]

Frontiers in Immunology, 2015
Despite effective anti-viral therapies, cytomegalovirus (CMV) is still associated with direct (CMV disease) and indirect effects (rejection and poor graft survival) in kidney transplant recipients. Recently, an unconventional T cell population (collectively designated as Vδ2(neg) γδ T cells) has been characterized during the anti-CMV immune response in
Couzi, Lionel, Pitard, Vincent, Moreau, Jean-François, Merville, Pierre, Déchanet-Merville, Julie   +4 more
openaire   +2 more sources

Multiple Receptor-Ligand Interactions Direct Tissue-Resident γδ T Cell Activation [PDF]

Frontiers in Immunology, 2014
γδ T cells represent a major T cell population in epithelial tissues, such as skin, intestine, and lung, where they function in maintenance of the epithelium and provide a crucial first line defense against environmental and pathogenic insults. Despite their importance, the molecular mechanisms directing their activation and function have remained ...
Witherden, Deborah. A., Ramirez, Kevin, Havran, Wendy L.   +2 more
openaire   +2 more sources

Obesity impairs γδ T cell homeostasis and antiviral function in humans. [PDF]

PLoS ONE, 2015
Obese patients are susceptible to increased morbidity and mortality associated with infectious diseases such as influenza A virus. γδ T cells and memory αβ T cells play key roles in reducing viral load by rapidly producing IFN-γ and lysing infected cells.
Anne E Costanzo, Kristen R Taylor, Shelley Dutt, Peggy P Han, Ken Fujioka, Julie M Jameson   +5 more
doaj   +1 more source

Cancer Immunotherapy Using γδT Cells: Dealing with Diversity [PDF]

Frontiers in Immunology, 2014
The broad and potent tumor-reactivity of innate-like γδT cells makes them valuable additions to current cancer immunotherapeutic concepts based on adaptive immunity, such as monoclonal antibodies and αβT cells. However, clinical success using γδT cells to treat cancer has so far fallen short.
Scheper, Wouter, Sebestyen, Zsolt, Kuball, Jürgen   +2 more
openaire   +3 more sources

Crosstalk between γδ T cells and the microbiota.

, 2021
The role of the microbiota in the development and function of γδ T cells-a T cell subset characterized by a T cell receptor composed of one γ-chain and one δ-chain-has been investigated in multiple organs in mice and humans.
Papotto, Pedro H, Yilmaz, Bahtiyar, Silva-Santos, Bruno, Papotto, Pedro H; id_orcid   +3 more
core   +1 more source

Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation [PDF]

Frontiers in Immunology, 2015
The contributions of γδ T-cells to immunity to infection or tumors critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells. These processes are molecularly controlled by surface receptors that capture key extracellular cues and convey downstream intracellular ...
Ribeiro, Sérgio T, Ribot, Julie, Silva-Santos, Bruno   +2 more
openaire   +4 more sources

Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells [PDF]

Frontiers in Immunology, 2014
Lymphocytes of the gamma delta (γδ) T-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. γδ T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoid cells.
Vasileios eBekiaris, Vasileios eBekiaris, John S Šedý, Carl F Ware   +3 more
openaire   +3 more sources

Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients

, 2022
Immunoparalysis and apoptosis of T cells are serious problems for the evolution of septic patients. We aimed to relate changes in the number of αβ and γδ T cells during hospital stay to the poor evolution of sepsis.
Peydró, Federico, Albert, Laura, Cuéllar Del Hoyo, María Del Carmen, Rico, Moises, Navarro, Amparo, Arribas, Miguel, Sorando-Serra, Rosa, Andreu-Ballester, Juan Carlos, García-Ballesteros, Carlos, López-Chuliá, Francesca, Galindo-Regal, Lorena   +10 more
core   +1 more source