Results 31 to 40 of about 31,118 (247)
Cancer Immunotherapy Using γδT Cells: Dealing with Diversity [PDF]
Frontiers in Immunology, 2014 The broad and potent tumor-reactivity of innate-like γδT cells makes them valuable additions to current cancer immunotherapeutic concepts based on adaptive immunity, such as monoclonal antibodies and αβT cells. However, clinical success using γδT cells to treat cancer has so far fallen short.
Scheper, Wouter +2 more
openaire +3 more sources
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation [PDF]
Frontiers in Immunology, 2015 The contributions of γδ T-cells to immunity to infection or tumors critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells. These processes are molecularly controlled by surface receptors that capture key extracellular cues and convey downstream intracellular ...
Ribeiro, Sérgio T +2 more
openaire +4 more sources
Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells [PDF]
Frontiers in Immunology, 2014 Lymphocytes of the gamma delta (γδ) T-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. γδ T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoid cells.
Vasileios eBekiaris +3 more
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Human Vδ2+ γδ T Cells Differentially Induce Maturation, Cytokine Production, and Alloreactive T Cell Stimulation by Dendritic Cells and B Cells [PDF]
Frontiers in Immunology, 2014 Human γδ T cells expressing the Vγ9Vδ2 T cell receptor can induce maturation of dendritic cells (DC) into antigen-presenting cells (APC) and B cells into antibody-secreting plasma cells. Since B cells are capable of presenting antigens to T cells, we investigated if Vγ9Vδ2 T cells can influence antigen-presentation by these cells. We report that Vγ9Vδ2
Doherty, Derek, Phelan, Andreea
openaire +5 more sources
A monoclonal antibody against T-cell receptor αβ induces endogenous cytokines and prevents mice from a lethal infection withListeria monocytogenes [PDF]
FEMS Immunology & Medical Microbiology, 1995 In vivo induction of cytokines by a monoclonal antibody (mAb) against T-cell receptor (TCR) alpha beta and the protective effect induced by the mAb on a lethal infection with Listeria monocytogenes were studied. Injection of anti-TCR alpha beta mAb induced rapid production of endogenous tumour necrosis factor in the spleens, and gamma interferon and ...
A, Nakane +6 more
openaire +2 more sources
A Novel Prothrombotic Pathway in Systemic Sclerosis Patients: Possible Role of Bisphosphonate-Activated γδ T Cells [PDF]
Frontiers in Immunology, 2014 Infusions of aminobisphonates (ABP) activate Vγ9δ2T cells in vivo and induce an acute inflammatory response in 30% of patients treated for osteoporosis. Following the observation of digital thrombosis in a systemic sclerosis (SSc) patient after treatment with an intravenous ABP, zoledronate (Zol), we evaluated whether patient and control peripheral ...
Victoria eMarcu-Malina +6 more
openaire +3 more sources
Pathogen-Specific Immune Fingerprints during Acute Infection: The Diagnostic Potential of Human γδ T-Cells [PDF]
Frontiers in Immunology, 2014 The last 200 years have seen a dramatic reduction in the prevalence and severity of microbial infections, due to the implementation of groundbreaking measures ranging from improved sanitation and hygiene and the introduction of aseptic techniques to the development of successful vaccines and the discovery of effective antibiotics.
Matthias eEberl +5 more
openaire +4 more sources
A Highly Focused Antigen Receptor Repertoire Characterizes γδ T Cells That are Poised to Make IL-17 Rapidly in Naive Animals [PDF]
Frontiers in Immunology, 2015 Interleukin (IL)-17 plays a key role in immunity. In acute infections, a rapid IL-17 response must be induced without prior antigen exposure, and γδ T cells are the major initial IL-17 producers. In fact, some γδ T cells make IL-17 within hours after an immune challenge. These cells appear to acquire the ability to respond to IL-1 and IL-23 and to make
Yu-Ling eWei +8 more
openaire +3 more sources
Expanded Human Blood-Derived γδT Cells Display Potent Antigen-Presentation Functions [PDF]
Frontiers in Immunology, 2014 Cell-based immunotherapy strategies target tumors directly (via cytolytic effector cells) or aim at mobilizing endogenous anti-tumor immunity. The latter approach includes dendritic cells (DC) most frequently in the form of in vitro cultured peripheral blood monocytes-derived DC.
M. W. A. Khan +8 more
openaire +4 more sources
Cells, 2020 Background: Pancreatic ductal adenocarcinoma (PDAC) is a malignant gastrointestinal disease. The enzyme indoleamine-2,3-dioxgenase (IDO) is often overexpressed in PDAC and its downstream metabolite kynurenine has been reported to inhibit T cell ...
Hannah Jonescheit +7 more
doaj +1 more source