Results 31 to 40 of about 4,401,008 (278)

γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation. [PDF]

PLoS ONE, 2013
Both antigen recognition and CD28 costimulation are required for the activation of naïve αβ T cells and their subsequent differentiation into cytokine-producing or cytotoxic effectors.
Renee M Laird, Benjamin J Wolf, Michael F Princiotta, Sandra M Hayes   +3 more
doaj   +1 more source

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing [PDF]

, 2019
BACKGROUND: Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to date.
Andersch, Lena, Eggert, Angelika, Flemmig, Carina, Grunewald, Laura, Henssen, Anton, Jensen, Michael C., Joussen, Antonia, Klaus, Anika, Künkele, Annette, Radke, Josefine, Rossig, Claudia, Schulte, Johannes H., Schumann, Elisa, Schwiebert, Silke, Winkler, Annika, Zirngibl, Felix   +15 more
core   +2 more sources

Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation [PDF]

Frontiers in Immunology, 2015
Despite effective anti-viral therapies, cytomegalovirus (CMV) is still associated with direct (CMV disease) and indirect effects (rejection and poor graft survival) in kidney transplant recipients. Recently, an unconventional T cell population (collectively designated as Vδ2(neg) γδ T cells) has been characterized during the anti-CMV immune response in
Couzi, Lionel, Pitard, Vincent, Moreau, Jean-François, Merville, Pierre, Déchanet-Merville, Julie   +4 more
openaire   +2 more sources

Obesity impairs γδ T cell homeostasis and antiviral function in humans. [PDF]

PLoS ONE, 2015
Obese patients are susceptible to increased morbidity and mortality associated with infectious diseases such as influenza A virus. γδ T cells and memory αβ T cells play key roles in reducing viral load by rapidly producing IFN-γ and lysing infected cells.
Anne E Costanzo, Kristen R Taylor, Shelley Dutt, Peggy P Han, Ken Fujioka, Julie M Jameson   +5 more
doaj   +1 more source

The Jekyll and Hyde story of IL17-Producing γδT Cells [PDF]

Frontiers in Immunology, 2015
In comparison to conventional αβT cells, γδT cells are considered as specialized T cells based on their contributions in regulating immune response. γδT cells sense early environmental signals and initiate local immune-surveillance. The development of functional subtypes of γδT cells takes place in the thymus but they also exhibit plasticity in ...
Patil, Rushikesh S., Bhat, Sajad A., Dar, Asif A., Chiplunkar, Shubhada V.   +3 more
openaire   +2 more sources

Cancer Immunotherapy Using γδT Cells: Dealing with Diversity [PDF]

Frontiers in Immunology, 2014
The broad and potent tumor-reactivity of innate-like γδT cells makes them valuable additions to current cancer immunotherapeutic concepts based on adaptive immunity, such as monoclonal antibodies and αβT cells. However, clinical success using γδT cells to treat cancer has so far fallen short.
Scheper, Wouter, Sebestyen, Zsolt, Kuball, Jürgen   +2 more
openaire   +3 more sources

Generation and first characterization of TRDC-knockout pigs lacking γδ T cells

Scientific Reports, 2021
The TRDC-locus encodes the T cell receptor delta constant region, one component of the γδ T cell receptor which is essential for development of γδ T cells.
Bjoern Petersen, Robert Kammerer, Antje Frenzel, Petra Hassel, Tung Huy Dau, Roswitha Becker, Angele Breithaupt, Reiner Georg Ulrich, Andrea Lucas-Hahn, Gregor Meyers   +9 more
doaj   +1 more source

γδ T cells as early sensors of tissue damage and mediators of secondary neurodegeneration [PDF]

Frontiers in Cellular Neuroscience, 2014
Spontaneous or medically induced reperfusion occurs in up to 70% of patients within 24 h after cerebral ischemia. Reperfusion of ischemic brain tissue can augment the inflammatory response that causes additional injury. Recently, T cells have been shown to be an essential part of the post-ischemic tissue damage, and especially IL-17 secreting T cells ...
Gelderblom, Mathias, Arunachalam, Priyadharshini, Magnus, Tim   +2 more
openaire   +3 more sources

Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation [PDF]

Frontiers in Immunology, 2015
The contributions of γδ T-cells to immunity to infection or tumors critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells. These processes are molecularly controlled by surface receptors that capture key extracellular cues and convey downstream intracellular ...
Ribeiro, Sérgio T, Ribot, Julie, Silva-Santos, Bruno   +2 more
openaire   +4 more sources

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. [PDF]

, 2012
Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal.
A Kadioglu, A Kadioglu, A Nalbant, A Strasser, AD Badley, Andrea M. Mitchell, C Riccardi, CA Janeway Jr, CK Sung, D Zhou, David H. Dockrell, DH Dockrell, DH Dockrell, DH Dockrell, DR Cundell, EE McGrath, FK Swirski, Frank R. DeLeo, G Matute-Bello, Helen M. Marriott, HM Marriott, HM Marriott, I Nicoletti, J Warwick-Davies, JA Carrero, Julie A. Preston, K Beiter, K Kemp, K LeMessurier, KA Browne, KE Price, L Galluzzi, L Maggi, L Ziegler-Heitbrock, LA Kirkham, M Daigneault, M Lenardo, M Witzenrath, MA Barocchi, MA Bewley, Marc Daigneault, Martin A. Bewley, MJ Jedrzejas, Moira K. B. Whyte, N Olivares-Zavaleta, N Oyaizu, NV Serbina, PA Kiener, R Malley, RA Hirst, Robert C. Read, RS Hotchkiss, RS Hotchkiss, RS Hotchkiss, SE Weber, SJ Webster, SL Newman, T Mattern, T Takahashi, Thushan I. De Silva, Timothy J. Mitchell, WL Farrar, WP Hausdorff, YJ Lu, Z Zhang   +64 more
core   +4 more sources