Results 51 to 60 of about 33,979 (285)
γδ T Cell-Mediated Antibody-Dependent Cellular Cytotoxicity with CD19 Antibodies Assessed by an Impedance-Based Label-Free Real-Time Cytotoxicity Assay [PDF]
Frontiers in Immunology, 2014 γδ T cells are not MHC restricted, elicit cytotoxicity against various malignancies, are present in early post-transplant phases in novel stem cell transplantation strategies and have been shown to mediate antibody-dependent cellular cytotoxicity (ADCC) with monoclonal antibodies (mAbs).
Ursula Jördis Eva Seidel +10 more
openaire +3 more sources
Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro
, 2013 Peer ...
Thompson, K. +3 more
core +1 more source
, 2023 Triple negative breast cancer (TNBC) lacks targeted therapy options. TNBC is enriched in breast cancer stem cells (BCSCs), which play a key role in metastasis, chemoresistance, relapse and mortality.
Swamy, Mahima; id_orcid, MRC PPU
core +1 more source
γδ T cells as a potential therapeutic agent for glioblastoma
Frontiers in Immunology, 2023 Although γδ T cells comprise a small population of T cells, they perform important roles in protecting against infection and suppressing tumors. With their distinct tissue-localizing properties, combined with their various target recognition mechanisms ...
In Kang +3 more
doaj +1 more source
On the Role of the Pre–T Cell Receptor in αβ versus γδ T Lineage Commitment
, 1998 The role of the pre–T cell receptor (TCR) in lineage commitment to the γδ versus αβ lineage of T cells was addressed by analyzing TCRβ chain rearrangements in γδ T cells from wild-type and pre-TCR-deficient mice by single cell polymerase chain reaction ...
von Boehmer, Harald +5 more
core +1 more source
Clinical & Translational Immunology, 2019 Background Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T‐cell receptor (TCR) clonal expansions.
Sneha Sant +19 more
doaj +1 more source
Superantigen Recognition by γδ T Cells SEA Recognition Site for Human Vγ2 T Cell Receptors
, 2001 Human γδ T cells expressing the Vγ2Vδ2 antigen receptors recognize nonpeptide prenyl pyrophosphate and alkylamine antigens. We find that they also recognize staphylococcal enterotoxin A superantigens in a manner distinct from the recognition of ...
Lamphear, James G. +6 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Notch Activity Influences the αβ versus γδ T Cell Lineage Decision
, 1997 The choice between the αβ or γδ T cell fates is influenced by the production of functional, in-frame rearrangements of the TCR genes, but the mechanism that controls the lineage choice is not known.
Fowlkes, B.J +6 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji +13 more
wiley +1 more source