Results 1 to 10 of about 215 (70)

Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer

Nature Communications, 2021
Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and ...
Rueyhung R. Weng, Hsuan-Hsuan Lu, Chien-Ting Lin, Chia-Chi Fan, Rong-Shan Lin, Tai-Chung Huang, Shu-Yung Lin, Yi-Jhen Huang, Yi-Hsiu Juan, Yi-Chieh Wu, Zheng-Ci Hung, Chi Liu, Xuan-Hui Lin, Wan-Chen Hsieh, Tzu-Yuan Chiu, Jung-Chi Liao, Yen-Ling Chiu, Shih-Yu Chen, Chong-Jen Yu, Hsing-Chen Tsai   +19 more
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γδ T Cell in Cerebral Ischemic Stroke: Characteristic, Immunity-Inflammatory Role, and Therapy

Frontiers in Neurology, 2022
Gamma-delta (γδ) T cells are a small subset of T cells that are reported to have a proinflammatory role in the pathophysiology of cerebral ischemia stroke (CIS). Upon activation by interleukin-1 beta (IL-1β), IL-23 and IL-18, γδ T cells are stimulated to
Li Wang, Chengye Yao, Jiayi Chen, Yangyang Ge, Chenchen Wang, Yu Wang, Fuquan Wang, Yan Sun, Maosha Dai, Yun Lin, Shanglong Yao   +10 more
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γδ T cells in 3D culture: The potential use in the therapeutics development

Clinical and Translational Discovery, 2022
Gamma‐delta (γδ) T cells have a promising future in various therapies due to their anti‐cancer and anti‐infectious function. As the unique T cell subset plays a vital role in the connection between innate and adaptive immunity, we discussed the potential
Shih‐Han Wang, Te‐An Lee, Chun‐Tse Kuo, Yun‐Ju Lai, Chia‐Wei Li   +4 more
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Immune Effects of γδ T Cells in Colorectal Cancer: A Review

Frontiers in Immunology, 2020
Gamma delta (γδ) T cells can effectively recognize and kill colorectal cancer (CRC) cells, thereby suppressing tumor progression via multiple mechanisms. They also have abilities to exert a protumor effect via secreting interleukin-17 (IL-17). γδ T cells
Rulan Ma, Dawei Yuan, Yizhan Guo, Rong Yan, Kang Li   +4 more
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Gamma Delta T Cells (γδ T Cells) in Health and Disease: In Memory of Professor Wendy Havran

Cells, 2020
Gamma delta (γδ) T cells are a small subset of CD3-positive T cells in the peripheral blood but occur at increased frequency in mucosal tissues [...]
Dieter Kabelitz
doaj   +1 more source

Augmenting human gamma delta lymphocytes for cancer therapy with chimeric antigen receptors

Exploration of Immunology, 2022
Gamma delta lymphocytes (γδ T) sit at the interface between innate and adaptive immunity. They have the capacity to recognize cancer cells by interaction of their surface receptors with an array of cancer cell surface target antigens.
Gabrielle M. Ferry, John Anderson
doaj   +1 more source

The protective role of tissue-resident interleukin 17A–producing gamma delta T cells in Mycobacterium leprae infection

Frontiers in Immunology, 2022
Mycobacterium leprae is a kind of disease-causing bacteria and results in leprosy in human. Gamma delta (γδ) T cell is a T-cell subset that is presented in both human dermis and epidermis.
Yan Liu, Chao Shi, Shanshan Ma, Yuelong Ma, Xinyuan Lu, Jianyu Zhu, Degang Yang   +6 more
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Dermal γδ T-Cells Can Be Activated by Mitochondrial Damage-Associated Molecular Patterns. [PDF]

PLoS ONE, 2016
Gamma delta T-cells have been shown to be important to the early immunoinflammatory response to injury, independent of infection. This unique T-cell population acts to regulate cell trafficking and the release of cytokines and growth factors.
Martin G Schwacha, Meenakshi Rani, Susannah E Nicholson, Aaron M Lewis, Travis L Holloway, Salvador Sordo, Andrew P Cap   +6 more
doaj   +1 more source

Characterization of Adaptive-like γδ T Cells in Ugandan Infants during Primary Cytomegalovirus Infection

Viruses, 2021
Gamma-delta (γδ) T cells are unconventional T cells that help control cytomegalovirus (CMV) infection in adults. γδ T cells develop early in gestation, and a fetal public γδ T cell receptor (TCR) clonotype is detected in congenital CMV infections ...
Jessica Tuengel, Sanya Ranchal, Alexandra Maslova, Gurpreet Aulakh, Maria Papadopoulou, Sibyl Drissler, Bing Cai, Cetare Mohsenzadeh-Green, Hugo Soudeyns, Sara Mostafavi, Peter van den Elzen, David Vermijlen, Laura Cook, Soren Gantt   +13 more
doaj   +1 more source

Revisiting the Role of γδ T Cells in Anti-CMV Immune Response after Transplantation

Viruses, 2021
Gamma delta (γδ) T cells form an unconventional subset of T lymphocytes that express a T cell receptor (TCR) consisting of γ and δ chains. Unlike conventional αβ T cells, γδ T cells share the immune signature of both the innate and the adaptive immunity.
Ahmed Gaballa, Faisal Alagrafi, Michael Uhlin, Arwen Stikvoort   +3 more
doaj   +1 more source