Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease [PDF]
Journal of Immunology Research, 2015 Behçet’s disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown.
Md. Samiul Hasan +3 more
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Genetic engineering and allogeneic optimization of Vδ1 γδ CAR-T cells (ADI-270) for cancer immunotherapy [PDF]
Journal for ImmunoTherapy of CancerGenetic engineering has fundamentally transformed T cell–based therapies by enabling tumor targeting capability, improving their functionality, and facilitating allogeneic use. These strategies—originally developed in αβ chimeric antigen receptor (CAR)-T
Wenlong Liu +2 more
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Potential of gamma/delta T cells for solid tumor immunotherapy
Frontiers in ImmunologyGamma/delta T (γδ T)cells possess a unique mechanism for killing tumors, making them highly promising and distinguished among various cell therapies for tumor treatment.
Dantong Zhu +9 more
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Harnessing the immunotherapeutic potentials of gamma delta T cells against hematological malignancies [PDF]
HemaSphereGamma delta (γδ) T cells, which constitute about 5%–10% of peripheral blood lymphocytes, play key roles in tumor immunosurveillance and are often enriched within epithelial tissues.
Charles Agbuduwe +2 more
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PD-1 signaling modulates interferon-γ production by Gamma Delta (γδ) T-Cells in response to leukemia. [PDF]
Oncoimmunology, 2019 Hoeres T +4 more
europepmc +2 more sources
The Cytotoxic Potential of Humanized γδ T Cells Against Human Cancer Cell Lines in In Vitro [PDF]
CellsCancer is a major global health issue, with rising incidence rates highlighting the urgent need for more effective treatments. Despite advances in cancer therapy, challenges such as adverse effects and limitations of existing treatments remain ...
Husheem Michael +8 more
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Nature Communications, 2021 Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and ...
Rueyhung R. Weng +19 more
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γδ T Cell in Cerebral Ischemic Stroke: Characteristic, Immunity-Inflammatory Role, and Therapy
Frontiers in Neurology, 2022 Gamma-delta (γδ) T cells are a small subset of T cells that are reported to have a proinflammatory role in the pathophysiology of cerebral ischemia stroke (CIS). Upon activation by interleukin-1 beta (IL-1β), IL-23 and IL-18, γδ T cells are stimulated to
Li Wang +10 more
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γδ T cells in 3D culture: The potential use in the therapeutics development
Clinical and Translational Discovery, 2022 Gamma‐delta (γδ) T cells have a promising future in various therapies due to their anti‐cancer and anti‐infectious function. As the unique T cell subset plays a vital role in the connection between innate and adaptive immunity, we discussed the potential
Shih‐Han Wang +4 more
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Immune Effects of γδ T Cells in Colorectal Cancer: A Review
Frontiers in Immunology, 2020 Gamma delta (γδ) T cells can effectively recognize and kill colorectal cancer (CRC) cells, thereby suppressing tumor progression via multiple mechanisms. They also have abilities to exert a protumor effect via secreting interleukin-17 (IL-17). γδ T cells
Rulan Ma +4 more
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