Results 21 to 30 of about 117,473 (191)

Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance

Microbiome, 2023
Background Gamma-delta (γδ) T cells are a major cell population in the intestinal mucosa and are key mediators of mucosal tolerance and microbiota composition.
Rafael M. Rezende, Laura M. Cox, Thais G. Moreira, Shirong Liu, Selma Boulenouar, Fyonn Dhang, Danielle S. LeServe, Brenda N. Nakagaki, Juliana R. Lopes, Bruna K. Tatematsu, Luisa Lemos, Julia Mayrink, Eduardo L. C. Lobo, Lydia Guo, Marilia G. Oliveira, Chantal Kuhn, Howard L. Weiner   +16 more
doaj   +1 more source

Gamma delta T-lymphocytes in hepatitis C and chronic liver disease

Frontiers in Immunology, 2014
Discovered thirty years ago, gamma delta (γδ) T-lymphocytes remain an intriguing and enigmatic T-cell subset. Although in humans they comprise a small fraction of the total circulating T-lymphocyte pool, they represent an important T-cell subset in ...
neil erajoriya, neil erajoriya, Joannah Ruth Fergusson, Jo eLeithead, Paul eKlenerman   +4 more
doaj   +1 more source

Non-V delta 2 gamma delta T lymphocytes as effectors of cancer immunotherapy [PDF]

, 2014
Gamma delta T cells (γδT) are potent mediators of antitumor cytotoxicity and have shown promising efficacy in early phase clinical trials. Most is known about the tumoricidal properties of cells bearing the Vδ2 T cell receptor chain, but recent studies ...
Anderson, J, Fisher, J, Gustafsson, K, Kramer, AM   +3 more
core   +1 more source

The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing

Clinical & Translational Immunology, 2019
Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes ...
Lucy C Sullivan, Evangeline M Shaw, Sanda Stankovic, Gregory I Snell, Andrew G Brooks, Glen P Westall   +5 more
doaj   +1 more source

Climate change, in the framework of the constructal law [PDF]

, 2011
Here we present a simple and transparent alternative to the complex models of Earth thermal behavior under time-changing conditions. We show the one-to-one relationship between changes in atmospheric properties and time-dependent changes in temperature ...
Alberton, Bruna, Almeida, Jurandy, Miranda, Waner O., Morellato, Leonor Patricia C., Santos, Jefersson A. dos, Torres, Ricardo da S.   +5 more
core   +1 more source

Mycobacterium tuberculosis promotes Th17 expansion via regulation of human dendritic cells toward a high CD14 and low IL-12p70 phenotype that reprograms upon exogenous IFN-γ. [PDF]

, 2014
Item does not contain fulltextThe capacity to develop protective immunity against mycobacteria is heterogeneously distributed among human beings, and it is currently unknown why the initial immune response induced against Mycobacterium tuberculosis (Mtb)
Acosta-Rodriguez, Agrawal, Bakdash, Bazil, Bazil, Bratke, Chackerian, Chen, Cheong, Chu, Cohn, Demedts, Desjardins, Evans, Fujii, Gautier, Geijtenbeek, Gerosa, Giacomini, Harding, Henderson, Hoene, Hsieh, Ishikawa, Iwasaki, Janne Marie Laursen, Jiao, Jonas Nørskov Søndergaard, Jung, Lai, Lauener, Lisbeth Buus Rosholm, Lucas, Martin, Nathan, Nathan, Nestle, Nigou, Ní Cheallaigh, Owaki, Ramakrishnan, Redford, Russell, Sallusto, Schreiber, Serbina, Susanne Brix, Søndergaard, Tailleux, Tailleux, Torrado, Trinchieri, Uehori, Underhill, Van der Aar, Van Haarst, van Haarst, Varol, Wilson, Winslow, Wolf, World Health Organization, Zanoni, Zenaro   +63 more
core   +1 more source

Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential

Cell Reports Medicine
Summary: Gamma-delta T cells (γδ T cells) play a crucial role in both innate and adaptive immunity within tumors, yet their presence and prognostic value in cancer remain underexplored. This study presents a large-scale analysis of γδ T cell receptor (γδ
Xiaoqing Yu, Li Song, Ling Cen, Biwei Cao, Ranran Tao, Yuanyuan Shen, Daniel Abate-Daga, Paulo C. Rodriguez, Jose R. Conejo-Garcia, Xuefeng Wang   +9 more
doaj   +1 more source

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Frontiers in Immunology, 2018
The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising ...
André E. Simões, Biagio Di Lorenzo, Biagio Di Lorenzo, Bruno Silva-Santos   +3 more
doaj   +1 more source

Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches

Cells, 2022
Gamma/delta (γδ) T cells are innate-like immune effectors that are a critical component linking innate and adaptive immune responses. They are recognized for their contribution to tumor surveillance and fight against infectious diseases.
Marta Sanz, Brendan T. Mann, Alisha Chitrakar, Natalia Soriano-Sarabia   +3 more
doaj   +1 more source

Pig peripheral blood mononuclear leucocyte subsets are heritable and genetically correlated with performance [PDF]

, 2008
Indicator traits used to select pigs for increased resistance to infection or improved health must be heritable and, preferably, be associated with improved performance.
Ahmadi, Cheeseman, Chen, Clapperton, Clapperton, Clapperton, Davis, de Haan, Denham, Denyer, Duarte, E.J. Glass, Edfors-Lilja, Edfors-Lilja, Eurell, Evans, Galina-Pantoja, Gheorgiou, Gilmour, Grellner, Hall, Hall, Haverson, Henryon, Henryon, Jayagopala Reddy, Joling, Lee, Lodoen, Loeffen, Luhtala, Lyons, M. Clapperton, Mallard, Morrison, Myrick, Ober, O’Connor, Pallarés, Parra, Pedrini, Petersen, Poppe, Regula, Roberts, S.C. Bishop, Saalmuller, Segalés, Snowder, Spurlock, Tecles, Thacker, Wonigeit, Yang, Zuckermann   +54 more
core   +1 more source