Results 31 to 40 of about 6,064 (187)

Human γδ T Cell Subsets and Their Clinical Applications for Cancer Immunotherapy [PDF]

, 2022
SIMPLE SUMMARY: Research into the immunotherapeutic potential of T cells has predominantly focused on conventional alpha beta (αβ) T cells, which recognize peptide antigens presented by polymorphic major histocompatibility complex (MHC) class I and class
Lili Yang, Rosenthal, Carl J., Rosenthal, Carl, Dunn, Zachary, Zachary Spencer Dunn, Lee, Derek, Yang Zhou, Dunn, Zachary Spencer, Carl J. Rosenthal, Derek Lee, Zhou, Yang, Penn, Natalie E., Yang, Lili, Natalie E. Penn, Penn, Natalie   +14 more
core   +1 more source

Human gamma-delta (γδ) T cells specific for common allergens are Th1-polarized in allergic donors. Yu et al.

, 2022
Gamma-delta (γδ) T cells are a bridge between innate and adaptive immunity and are involved in various immunological disorders. Here we identify and present an initial characterization of human allergen-reactive γδ T cells in peripheral blood, using an ...
Yu, E (via Mendeley Data)
core   +1 more source

Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential

Cell Reports Medicine
Summary: Gamma-delta T cells (γδ T cells) play a crucial role in both innate and adaptive immunity within tumors, yet their presence and prognostic value in cancer remain underexplored. This study presents a large-scale analysis of γδ T cell receptor (γδ
Xiaoqing Yu, Li Song, Ling Cen, Biwei Cao, Ranran Tao, Yuanyuan Shen, Daniel Abate-Daga, Paulo C. Rodriguez, Jose R. Conejo-Garcia, Xuefeng Wang   +9 more
doaj   +1 more source

Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro

, 2013
Peer ...
Thompson, K., A Pappalardo, Pappalardo, A., K Thompson   +3 more
core   +1 more source

Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches

Cells, 2022
Gamma/delta (γδ) T cells are innate-like immune effectors that are a critical component linking innate and adaptive immune responses. They are recognized for their contribution to tumor surveillance and fight against infectious diseases.
Marta Sanz, Brendan T. Mann, Alisha Chitrakar, Natalia Soriano-Sarabia   +3 more
doaj   +1 more source

Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome

Life Science Alliance, 2021
Single-cell sequencing of γδ-T cells from human blood and tumours revealed novel markers of subtypes with distinct effector functions and a subtype that is associated with favourable clinical outcome.
Katerina Boufea, Victor Gonzalez-Huici, Marcus Lindberg, Nelly N Olova, Stefan Symeonides, Olga Oikonomidou, Nizar N Batada   +6 more
doaj   +1 more source

Three-Dimensional Modeling of Camelus dromedarius T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length

Antibodies
Background: In the adaptive immune response of the dromedary (Camelus dromedarius, Camdro), the T cell receptor (TR) repertoire of the gamma–delta (γδ) T cells is unusually diversified both by somatic hypermutation in rearranged TR gamma (TRG) and delta (
Salvatrice Ciccarese, Marie-Paule Lefranc, Giulia C. M. Perrone, Pietro D’Addabbo, Ciro Leonardo Pierri   +4 more
doaj   +1 more source

Activated Chicken Gamma Delta T Cells Are Involved in Protective Immunity against Marek’s Disease

Viruses, 2023
Gamma delta (γδ) T cells play a significant role in the prevention of viral infection and tumor surveillance in mammals. Although the involvement of γδ T cells in Marek’s disease virus (MDV) infection has been suggested, their detailed contribution to ...
Ayumi Matsuyama-Kato, Bahram Shojadoost, Nitish Boodhoo, Sugandha Raj, Mohammadali Alizadeh, Fatemeh Fazel, Charlotte Fletcher, Jiayu Zheng, Bhavya Gupta, Mohamed Faizal Abdul-Careem, Brandon L. Plattner, Shahriar Behboudi, Shayan Sharif   +12 more
doaj   +1 more source

Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes

, 2001
Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity.
Nicholls, Philip K., Parry, N.R., Gough, Gerald W., Anderson, Davina M., Gough, G.W., Stanley, M.A., Parry, Nigel R., Stanley, Margaret A., Nicholls, P.K., Moore, Peter F., Moore, Richard A., Moore, R.A., Anderson, D.M., Moore, P.F.   +13 more
core   +1 more source

Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males

Nature Communications, 2023
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and adaptive immune responses play an important role in the pathogenesis of TBI.
Hadi Abou-El-Hassan, Rafael M. Rezende, Saef Izzy, Galina Gabriely, Taha Yahya, Bruna K. Tatematsu, Karl J. Habashy, Juliana R. Lopes, Gislane L. V. de Oliveira, Amir-Hadi Maghzi, Zhuoran Yin, Laura M. Cox, Rajesh Krishnan, Oleg Butovsky, Howard L. Weiner   +14 more
doaj   +1 more source