Results 31 to 40 of about 117,473 (191)

Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome

Life Science Alliance, 2021
Single-cell sequencing of γδ-T cells from human blood and tumours revealed novel markers of subtypes with distinct effector functions and a subtype that is associated with favourable clinical outcome.
Katerina Boufea, Victor Gonzalez-Huici, Marcus Lindberg, Nelly N Olova, Stefan Symeonides, Olga Oikonomidou, Nizar N Batada   +6 more
doaj   +1 more source

Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer. [PDF]

, 2019
Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy.
Bruni E, Cazzetta V, Cimino M, Dieli F, Donadon M, Leonardi G, Mavilio D., Mikulak J, Spata G, Torzilli G   +9 more
core   +1 more source

Three-Dimensional Modeling of Camelus dromedarius T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length

Antibodies
Background: In the adaptive immune response of the dromedary (Camelus dromedarius, Camdro), the T cell receptor (TR) repertoire of the gamma–delta (γδ) T cells is unusually diversified both by somatic hypermutation in rearranged TR gamma (TRG) and delta (
Salvatrice Ciccarese, Marie-Paule Lefranc, Giulia C. M. Perrone, Pietro D’Addabbo, Ciro Leonardo Pierri   +4 more
doaj   +1 more source

Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

Frontiers in Immunology, 2017
The unique features of gamma-delta (γδ) T cells, related to their antigen recognition capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates that could be targeted to induce durable immunity in the context of ...
Myriam Lawand, Myriam Lawand, Myriam Lawand, Julie Déchanet-Merville, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +6 more
doaj   +1 more source

Activated Chicken Gamma Delta T Cells Are Involved in Protective Immunity against Marek’s Disease

Viruses, 2023
Gamma delta (γδ) T cells play a significant role in the prevention of viral infection and tumor surveillance in mammals. Although the involvement of γδ T cells in Marek’s disease virus (MDV) infection has been suggested, their detailed contribution to ...
Ayumi Matsuyama-Kato, Bahram Shojadoost, Nitish Boodhoo, Sugandha Raj, Mohammadali Alizadeh, Fatemeh Fazel, Charlotte Fletcher, Jiayu Zheng, Bhavya Gupta, Mohamed Faizal Abdul-Careem, Brandon L. Plattner, Shahriar Behboudi, Shayan Sharif   +12 more
doaj   +1 more source

Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males

Nature Communications, 2023
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and adaptive immune responses play an important role in the pathogenesis of TBI.
Hadi Abou-El-Hassan, Rafael M. Rezende, Saef Izzy, Galina Gabriely, Taha Yahya, Bruna K. Tatematsu, Karl J. Habashy, Juliana R. Lopes, Gislane L. V. de Oliveira, Amir-Hadi Maghzi, Zhuoran Yin, Laura M. Cox, Rajesh Krishnan, Oleg Butovsky, Howard L. Weiner   +14 more
doaj   +1 more source

In vitro-differentiated T/natural killer-cell progenitors derived from human CD34+ cells mature in the thymus [PDF]

, 2010
Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a treatment option for patients with hematopoietic malignancies that is hampered by treatment-related morbidity and mortality, in part the result of opportunistic infections, a direct
Borsotti, C, Bos, G M, Cloosen, S, Germeraad, W T, Hesselink, R, Katsura, Y, Kawamoto, H, Leewis, B, Manz, M G, Meek, B, Schnijderberg, M C, van der Poel, M W, Van Elssen, C H, Vanderlocht, J   +13 more
core   +1 more source

Role of innate T cells in anti-bacterial immunity [PDF]

, 2015
Innate T cells are a heterogeneous group of αβ and γδ T cells that respond rapidly (
Aggarwal, Arigoni, Battistini, Behr, Bendelac, Berzins, Berzofsky, Billerbeck, Bonneville, Brandes, Brennan, Brigl, Brigl, Buchmeier, Carreno, Carvalho, Chackerian, Chua, Cohen, Collins, Darmoise, De Libero, DiTirro, Dusseaux, Eguchi, Espinosa, Fergusson, Fernandez, Fletcher, Fujita, Gao, Georgel, Giabbai, Godfrey, Gold, Gold, Grimaldi, Harly, He, Horikoshi, Ivanov, Joyce, Joyee, Kalyan, Kawakami, Kee, Kinjo, Kinjo, Kinjo, Kjer-Nielsen, Kroca, Lanier, Le Bourhis, Leslie, Lo, Luoma, Maggi, Martin, Mattner, Meierovics, Miyagawa, Morita, Nauciel, Olszak, Paget, Paget, Paget, Paget, Park, Pechhold, Reantragoon, Reantragoon, Russano, Sada-Ovalle, Salio, Sandstrom, Sarikonda, Seach, Shin, Silva, Skeen, Sriram, Stanic, Takahashi, Tessmer, Tilloy, Tupin, Turtle, Uldrich, Ussher, van der Sluijs, Van Kaer, Vavassori, Voyle, Wingender, Wong, Wong, Wu, Xiao, Yuling, Zheng   +100 more
core   +1 more source

Mixing signals: Molecular turn ons and turn offs for innate γδ Τ cells

Frontiers in Immunology, 2014
Lymphocytes of the gamma delta (γδ) T cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors a large proportion respond as innate effectors. γδ T cells are poised to combat infection by responding rapidly
Vasileios eBekiaris, Vasileios eBekiaris, John S Šedý, Carl F Ware   +3 more
doaj   +1 more source

Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes. [PDF]

, 1988
Analyses of TCR-bearing murine and human T cells have defined a unique subpopulation of T cells that express the TCR-gamma/delta proteins. The specificity of TCR-gamma/delta T cells and their role in the immune response have not yet been elucidated. Here
Bluestone, JA, Cotterman, M, Cron, RQ, Houlden, BA, Matis, LA   +4 more
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