Results 11 to 20 of about 117,473 (191)

Gamma Delta T Cells (γδ T Cells) in Health and Disease: In Memory of Professor Wendy Havran

Cells, 2020
Gamma delta (γδ) T cells are a small subset of CD3-positive T cells in the peripheral blood but occur at increased frequency in mucosal tissues [...]
Dieter Kabelitz
doaj   +1 more source

Augmenting human gamma delta lymphocytes for cancer therapy with chimeric antigen receptors

Exploration of Immunology, 2022
Gamma delta lymphocytes (γδ T) sit at the interface between innate and adaptive immunity. They have the capacity to recognize cancer cells by interaction of their surface receptors with an array of cancer cell surface target antigens.
Gabrielle M. Ferry, John Anderson
doaj   +1 more source

The protective role of tissue-resident interleukin 17A–producing gamma delta T cells in Mycobacterium leprae infection

Frontiers in Immunology, 2022
Mycobacterium leprae is a kind of disease-causing bacteria and results in leprosy in human. Gamma delta (γδ) T cell is a T-cell subset that is presented in both human dermis and epidermis.
Yan Liu, Chao Shi, Shanshan Ma, Yuelong Ma, Xinyuan Lu, Jianyu Zhu, Degang Yang   +6 more
doaj   +1 more source

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients [PDF]

, 2019
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). ROR gamma t, the key Thelperl7 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ...
Coudenys, Julie, Cypers, Heleen, Decruy, Tine, Elewaut, Dirk, Gyselbrecht, Lieve, Harcken, Christian, Hoyt, Kathleen, Hughes, Robert, Jacques, Peggy, Labadia, Mark E., Martens, Liesbet, Mortier, Céline, Nabozny, Gerald, Piette, Yves, Saeys, Yvan, Schryvers, Nadia, Smith, Dustin, Turner, Michael, Van Calenbergh, Serge, Van den Bosch, Filip, Van Gassen, Sofie, Varkas, Gaëlle, Venken, Koen, Verheugen, Eveline, Wahle, Joseph, Wang, Chao-Ting, Wayne, Anita L., Wittoek, Ruth   +27 more
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Dermal γδ T-Cells Can Be Activated by Mitochondrial Damage-Associated Molecular Patterns. [PDF]

PLoS ONE, 2016
Gamma delta T-cells have been shown to be important to the early immunoinflammatory response to injury, independent of infection. This unique T-cell population acts to regulate cell trafficking and the release of cytokines and growth factors.
Martin G Schwacha, Meenakshi Rani, Susannah E Nicholson, Aaron M Lewis, Travis L Holloway, Salvador Sordo, Andrew P Cap   +6 more
doaj   +1 more source

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours [PDF]

, 2016
Natural killer (NK) lymphocytes are part of the innate immune system and are important in immune protection against tumourigenesis. NK cells display a broad repertoire of activating and inhibitory cell surface receptors that regulate NK cell activity ...
Filtjens, Jessica, Keirsse, Jiri, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Taghon, Tom, Taveirne, Sylvie, Van Acker, Aline, Van Ammel, Els, Van Ginderachter, Jo A, Vandekerckhove, Bart   +10 more
core   +2 more sources

Characterization of Adaptive-like γδ T Cells in Ugandan Infants during Primary Cytomegalovirus Infection

Viruses, 2021
Gamma-delta (γδ) T cells are unconventional T cells that help control cytomegalovirus (CMV) infection in adults. γδ T cells develop early in gestation, and a fetal public γδ T cell receptor (TCR) clonotype is detected in congenital CMV infections ...
Jessica Tuengel, Sanya Ranchal, Alexandra Maslova, Gurpreet Aulakh, Maria Papadopoulou, Sibyl Drissler, Bing Cai, Cetare Mohsenzadeh-Green, Hugo Soudeyns, Sara Mostafavi, Peter van den Elzen, David Vermijlen, Laura Cook, Soren Gantt   +13 more
doaj   +1 more source

Revisiting the Role of γδ T Cells in Anti-CMV Immune Response after Transplantation

Viruses, 2021
Gamma delta (γδ) T cells form an unconventional subset of T lymphocytes that express a T cell receptor (TCR) consisting of γ and δ chains. Unlike conventional αβ T cells, γδ T cells share the immune signature of both the innate and the adaptive immunity.
Ahmed Gaballa, Faisal Alagrafi, Michael Uhlin, Arwen Stikvoort   +3 more
doaj   +1 more source

Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis [PDF]

, 1996
The function of the minor subset of T lymphocytes bearing the gamma delta T cell antigen receptor is uncertain. Although some gamma delta T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen ...
Alderson, Alderson, Augustin, Bellgrau, Born, Brennan, Carding, Cooper, David Lynch, David Wilson, De Libero, Emoto, French, Gavrieli, Goodman, Griffith, Groh, Haas, Haregewoi, Holoshitz, Huber, Janis, Jurg Tschopp, Kagi, Karen Roessner, Leonard H. Sigal, Lowin, Mariani, McMenamin, Michael S. Vincent, Modlin, Morita, Mukasa, Nagata, O'Brien, Parker, Pelegri, Peterman, Ralph C. Budd, Roessner, Rouvier, Rust, Sgorc, Sheldon M. Cooper, Spencer, Suda, Tanaka, Wright, Yssel   +48 more
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Synthesis of analogues of (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate, an isoprenoid precursor and human γδ T cell activator [PDF]

, 2008
(E)-1-Hydroxy-2-methyl-but-2-enyl 4-diphosphate (HMBPP) is an intermediate in the non-mevalonate pathway for the biosynthesis of isoprenoids and also serves as a very strong activator of human gamma delta T cells expressing V gamma 9V delta 2 receptors ...
Jomaa, Hassan, Lacey, Carl Jeffrey, Röhrich, Rene C, Van Calenbergh, Serge, Van Hoof, Steven, Wiesner, Jochen   +5 more
core   +2 more sources