Results 11 to 20 of about 6,064 (187)

Key players of immunosuppression in epithelial malignancies: Tumor‐infiltrating myeloid cells and γδ T cells

Cancer Reports
Background The tumor microenvironment of solid tumors governs the differentiation of otherwise non‐immunosuppressive macrophages and gamma delta (γδ) T cells into strong immunosuppressors while promoting suppressive abilities of known immunosuppressors ...
Baishali Tamuli, Sakshi Sharma, Meena Patkar, Subir Biswas   +3 more
doaj   +2 more sources

Gamma delta T cells and their immunotherapeutic potential in cancer

Biomarker Research
Gamma–delta (γδ) T cells are a unique subset of T lymphocytes that play diverse roles in immune responses, bridging innate and adaptive immunity. With growing interest in their potential for cancer immunotherapy, a comprehensive and inclusive exploration
Stephen G. Cieslak, Reza Shahbazi
doaj   +2 more sources

Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications [PDF]

Frontiers in Immunology, 2017
The unique features of gamma-delta (γδ) T cells, related to their antigen recognition capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates that could be targeted to induce durable immunity in the context of ...
Myriam Lawand, Myriam Lawand, Myriam Lawand, Julie Déchanet-Merville, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +6 more
doaj   +3 more sources

The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing

Clinical & Translational Immunology, 2019
Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes ...
Lucy C Sullivan, Evangeline M Shaw, Sanda Stankovic, Gregory I Snell, Andrew G Brooks, Glen P Westall   +5 more
doaj   +2 more sources

Dermal γδ T-Cells Can Be Activated by Mitochondrial Damage-Associated Molecular Patterns. [PDF]

PLoS ONE, 2016
Gamma delta T-cells have been shown to be important to the early immunoinflammatory response to injury, independent of infection. This unique T-cell population acts to regulate cell trafficking and the release of cytokines and growth factors.
Martin G Schwacha, Meenakshi Rani, Susannah E Nicholson, Aaron M Lewis, Travis L Holloway, Salvador Sordo, Andrew P Cap   +6 more
doaj   +2 more sources

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Frontiers in Immunology, 2018
The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising ...
André E. Simões, Biagio Di Lorenzo, Biagio Di Lorenzo, Bruno Silva-Santos   +3 more
doaj   +2 more sources

The emerging roles of gamma-delta T cells in tissue inflammation in experimental autoimmune encephalomyelitis

Frontiers in Immunology, 2016
γδ (gamma delta) T cells, a small population of unconventional T cells, have been seen in central nervous system (CNS) lesions of multiple sclerosis (MS) patients, but their function in disease activity is not clearly understood.
Amit eAwasthi, Sakshi eMalik, Muzamil Yaqub Want   +2 more
doaj   +2 more sources

CD8+γδ T Cells Are More Frequent in CMV Seropositive Bone Marrow Grafts and Display Phenotype of an Adaptive Immune Response

Stem Cells International, 2019
The role of gamma delta (γδ) T cells in human cytomegalovirus (HCMV) immune surveillance has been the focus of research interest for years. Recent reports have shown a substantial clonal proliferation of γδ T cells in response to HCMV, shedding light on ...
Ahmed Gaballa, Lucas C. M. Arruda, Emelie Rådestad, Michael Uhlin   +3 more
doaj   +2 more sources

Characteristics and significance of γδ T cells in colorectal cancer [PDF]

OncoImmunology
Gamma-delta T cells are a subset of T cells that have features of both innate and adaptive immunity. Their role in cancer remains controversial, since both anti- and protumor functions have been reported.
Henna Karjalainen, Jouni Härkönen, Päivi Sirniö, Hanna Elomaa, Ville K. Äijälä, Meeri Kastinen, Vilja V. Tapiainen, Sara A. Väyrynen, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Anne Tuomisto, Markus J. Mäkinen, Juha P. Väyrynen   +20 more
doaj   +2 more sources

Gamma-delta (γδ) T cells: friend or foe in cancer development? [PDF]

J Transl Med, 2018
Background γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity.
Zhao Y, Niu C, Cui J.
europepmc   +2 more sources