Results 11 to 20 of about 250 (105)

Gamma delta T-lymphocytes in hepatitis C and chronic liver disease

Frontiers in Immunology, 2014
Discovered thirty years ago, gamma delta (γδ) T-lymphocytes remain an intriguing and enigmatic T-cell subset. Although in humans they comprise a small fraction of the total circulating T-lymphocyte pool, they represent an important T-cell subset in ...
neil erajoriya, neil erajoriya, Joannah Ruth Fergusson, Jo eLeithead, Paul eKlenerman   +4 more
doaj   +1 more source

Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance

Microbiome, 2023
Background Gamma-delta (γδ) T cells are a major cell population in the intestinal mucosa and are key mediators of mucosal tolerance and microbiota composition.
Rafael M. Rezende, Laura M. Cox, Thais G. Moreira, Shirong Liu, Selma Boulenouar, Fyonn Dhang, Danielle S. LeServe, Brenda N. Nakagaki, Juliana R. Lopes, Bruna K. Tatematsu, Luisa Lemos, Julia Mayrink, Eduardo L. C. Lobo, Lydia Guo, Marilia G. Oliveira, Chantal Kuhn, Howard L. Weiner   +16 more
doaj   +1 more source

The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing

Clinical & Translational Immunology, 2019
Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes ...
Lucy C Sullivan, Evangeline M Shaw, Sanda Stankovic, Gregory I Snell, Andrew G Brooks, Glen P Westall   +5 more
doaj   +1 more source

Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential

Cell Reports Medicine
Summary: Gamma-delta T cells (γδ T cells) play a crucial role in both innate and adaptive immunity within tumors, yet their presence and prognostic value in cancer remain underexplored. This study presents a large-scale analysis of γδ T cell receptor (γδ
Xiaoqing Yu, Li Song, Ling Cen, Biwei Cao, Ranran Tao, Yuanyuan Shen, Daniel Abate-Daga, Paulo C. Rodriguez, Jose R. Conejo-Garcia, Xuefeng Wang   +9 more
doaj   +1 more source

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Frontiers in Immunology, 2018
The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising ...
André E. Simões, Biagio Di Lorenzo, Biagio Di Lorenzo, Bruno Silva-Santos   +3 more
doaj   +1 more source

Potential of gamma/delta T cells for solid tumor immunotherapy

Frontiers in Immunology
Gamma/delta T (γδ T)cells possess a unique mechanism for killing tumors, making them highly promising and distinguished among various cell therapies for tumor treatment.
Dantong Zhu, Xijing Ren, Xijing Ren, Wanting Xie, Jianjun Chen, Shiying Liang, Shiying Liang, Mingzhe Jiang, Junyi Wang, Zhendong Zheng   +9 more
doaj   +1 more source

Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

Frontiers in Immunology, 2017
The unique features of gamma-delta (γδ) T cells, related to their antigen recognition capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates that could be targeted to induce durable immunity in the context of ...
Myriam Lawand, Myriam Lawand, Myriam Lawand, Julie Déchanet-Merville, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +6 more
doaj   +1 more source

Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches

Cells, 2022
Gamma/delta (γδ) T cells are innate-like immune effectors that are a critical component linking innate and adaptive immune responses. They are recognized for their contribution to tumor surveillance and fight against infectious diseases.
Marta Sanz, Brendan T. Mann, Alisha Chitrakar, Natalia Soriano-Sarabia   +3 more
doaj   +1 more source

Three-Dimensional Modeling of Camelus dromedarius T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length

Antibodies
Background: In the adaptive immune response of the dromedary (Camelus dromedarius, Camdro), the T cell receptor (TR) repertoire of the gamma–delta (γδ) T cells is unusually diversified both by somatic hypermutation in rearranged TR gamma (TRG) and delta (
Salvatrice Ciccarese, Marie-Paule Lefranc, Giulia C. M. Perrone, Pietro D’Addabbo, Ciro Leonardo Pierri   +4 more
doaj   +1 more source

Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome

Life Science Alliance, 2021
Single-cell sequencing of γδ-T cells from human blood and tumours revealed novel markers of subtypes with distinct effector functions and a subtype that is associated with favourable clinical outcome.
Katerina Boufea, Victor Gonzalez-Huici, Marcus Lindberg, Nelly N Olova, Stefan Symeonides, Olga Oikonomidou, Nizar N Batada   +6 more
doaj   +1 more source