Results 51 to 60 of about 6,064 (187)

Preclinical platforms to study therapeutic efficacy of human γδ T cells

Clinical and Translational Medicine, 2022
Background Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell therapy, however, their treatment efficacy is not satisfactory.
Lingling Ou, Huaishan Wang, Hui Huang, Zhiyan Zhou, Qiang Lin, Yeye Guo, Tara Mitchell, Alexander C. Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Wei Guo, Joseph Salvino, Meenhard Herlyn, Xiaowei Xu   +14 more
doaj   +1 more source

Immune Cell Responses to the Cattle Lungworm, Dictyocaulus viviparus [PDF]

, 2008
The cattle lungworm, Dictyocaulus viviparus, is a parasitic nematode, which can cause severe pulmonary disease. Repeated natural infections result in protective immunity, and a live attenuated vaccine exists.
Hagberg, Malin
core  

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Gamma/delta T cells and the diagnosis of coeliac disease

, 1991
SUMMARY Gamma/delta T cells are increased in the gut epithelium of patients with coeliac disease compared with normal controls. The aim of this study was to determine whether the increase in yd intraepithelial lymphocytes (IEL) is specific
J SPENCER, J A WALKER-SMITH, T T MACDONALD, P G ISAACSON, A J THOMAS   +4 more
core   +1 more source

Gamma delta (γδ) T cells: origin, phenotype, functions

Медицинская иммунология
The primary function of γδT cells is to regulate the responses of innate and adaptive immune systems. These cells also play a role in antibacterial, antiviral and antitumor immune responses, regulate inflammation, maintain homeostasis in barrier tissues,
D. I. Sokolov
doaj   +1 more source

Infiltrated IL-17A-producing gamma delta T cells play a protective role in sepsis-induced liver injury and are regulated by CCR6 and gut commensal microbes

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionSepsis is a common but serious disease in intensive care units, which may induce multiple organ dysfunctions such as liver injury. Previous studies have demonstrated that gamma delta (γδ) T cells play a protective role in sepsis. However, the
Jian Wan, Qian Zhang, Yilong Hao, Zhang Tao, Wei Song, Song Chen, Long Qin, Weidong Song, Yi Shan   +8 more
doaj   +1 more source

Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function [PDF]

, 2023
Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in mediating antitumor responses to immune checkpoint inhibition is unknown.
Arias-Badia, Marcel, Fong, Lawrence, Diamond Luong, Brandon Chen, Ilano, Arielle, Chang, Hewitt, Li Zhang, Donna L. Farber, Luong, Diamond, Aran, Dvir, Farber, Donna L, Arielle Ilano, Lanier, Lewis L, Rancan, Chiara, Lewis L. Lanier, Chiara Rancan, Zhang, Li, Lawrence Fong, Dogra, Pranay, Meng, Maxwell V, Maxwell V. Meng, Kwek, Serena S, Chen, Brandon, Dvir Aran, Serena S. Kwek, Yang, Hai, Li, Jacky, Hewitt Chang, Pranay Dogra, Hai Yang, Jacky Li, Marcel Arias-Badia   +31 more
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Programmable Multi‐Axially Aligned Aerogels via Sequential Freeze‐Casting for Tailored Anisotropy and Tunable Mechanics

Advanced Science, EarlyView.
Conventional single‐gradient freeze‐casting typically produces unidirectional porous architectures with limited transverse connectivity. The Sequential Hybridization by Infiltration and Freeze‐casting Technique (SHIFT) addresses this constraint by integrating secondary aligned structures within a preformed primary scaffold.
Kiho Sung, Sungchul Shin
wiley   +1 more source

Atomically Modulating Competing Exchange Interactions in Centrosymmetric Skyrmion Hosts GdRu2X2 (X = Si and Ge)

Advanced Electronic Materials, EarlyView.
Our work bridges the gap between skyrmion discovery and material design by demonstrating how atomic‐scale control of exchange interactions enables tunable skyrmion phase transitions in centrosymmetric magnetic metals. ABSTRACT Magnetic skyrmions are topologically protected spin states that hold promise for shaping the future of electronics.
Dasuni N. Rathnaweera, Xudong Huai, K. Ramesh Kumar, Michał J. Winiarski, Tomasz Klimczuk, Allana G. Iwanicki, Satya K. Kushwaha, Martin Mourigal, Tyrel M. McQueen, Thao T. Tran   +9 more
wiley   +1 more source