Results 51 to 60 of about 117,473 (191)
Frontiers in Immunology, 2016 γδ (gamma delta) T cells, a small population of unconventional T cells, have been seen in central nervous system (CNS) lesions of multiple sclerosis (MS) patients, but their function in disease activity is not clearly understood.
Amit eAwasthi +2 more
doaj +1 more source
Predominant variable region gene usage by gamma/delta T cell receptor-bearing cells in the adult thymus. [PDF]
, 1988 Previous studies have indicated that the diversity of gamma genes expressed by gamma/delta-bearing murine T cells is limited, but comparable information concerning the expressed diversity of delta genes is lacking. In this study, we have investigated the
Korman, A +4 more
core
Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. [PDF]
, 2017 Vδ2+ γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria.
Bowen, Katherine +17 more
core +2 more sources
Advanced Science, EarlyView.This study achieves anisotropic thermal expansion tuning in Nd2(Co1‐xFex)17‐yCry compounds via a magnetoelastic strategy. Variable‐temperature synchrotron X‐ray diffraction reveals that increased Fe content induces switchable lattice responses. Compositional control reduces the volume expansion coefficient αV by 20% (x═0.7) and modulates TC (442–625 K),
Jiayuan Li +8 more
wiley +1 more source
Preclinical platforms to study therapeutic efficacy of human γδ T cells
Clinical and Translational Medicine, 2022 Background Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell therapy, however, their treatment efficacy is not satisfactory.
Lingling Ou +14 more
doaj +1 more source
Defective development of gamma/delta T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor gamma genes. [PDF]
, 1999 Mice lacking the interleukin 7 receptor (IL-7R) generate alpha/beta T cells at a detectable but greatly reduced rate, but gamma/delta T cells are completely absent.
Coles, M, Kang, J, RAULET, David H.
core +1 more source
Single and cross-generation natural hedging of longevity and financial risk [PDF]
, 2012 The paper provides natural hedging strategies among death benefits and annuities written on a single and on different generations. It obtains closed-form Delta and Gamma hedges, in the presence of both longevity and interest rate risk.
Luciano, Elisa +2 more
core +2 more sources
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
Gamma delta T cells and their immunotherapeutic potential in cancer
Biomarker ResearchGamma–delta (γδ) T cells are a unique subset of T lymphocytes that play diverse roles in immune responses, bridging innate and adaptive immunity. With growing interest in their potential for cancer immunotherapy, a comprehensive and inclusive exploration
Stephen G. Cieslak, Reza Shahbazi
doaj +1 more source
Gamma delta (γδ) T cells: origin, phenotype, functions
Медицинская иммунологияThe primary function of γδT cells is to regulate the responses of innate and adaptive immune systems. These cells also play a role in antibacterial, antiviral and antitumor immune responses, regulate inflammation, maintain homeostasis in barrier tissues,
D. I. Sokolov
doaj +1 more source