Results 71 to 80 of about 117,473 (191)

T cells, the next big target in axSpA?

Arthritis &Rheumatology, Accepted Article.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells.
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Unraveling the role of γδ T cells in the pathogenesis of an oncogenic avian herpesvirus

mBio
Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that causes deadly lymphomas in chickens. In chickens, up to 50% of all peripheral T cells are gamma delta (γδ) T cells.
Mohammad A. Sabsabi, Ahmed Kheimar, Yu You, Dominik von La Roche, Sonja Härtle, Thomas W. Göbel, Theresa von Heyl, Benjamin Schusser, Benedikt B. Kaufer   +8 more
doaj   +1 more source

A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition. [PDF]

, 2013
GABAA receptors (GABARs) are the targets of a wide variety of modulatory drugs which enhance chloride flux through GABAR ion channels. Certain GABAR modulators appear to acutely enhance the function of δ subunit-containing GABAR subtypes responsible for ...
Karakossian, Movses H, Meera, Pratap, Otis, Thomas S, Santhakumar, Vijayalakshmi   +3 more
core   +2 more sources

Influence of Carboxylate Ligand Variation on Structure, Magnetic Exchange, and Magnetocaloric Performance in Hexanuclear Gd(III) Complexes

Chemistry – A European Journal, EarlyView.
ABSTRACT Hexanuclear cyclic Gd(III) coordination compounds are promising candidates for magnetic and magnetocaloric applications, yet systematic series remain rare due to synthetic challenges. We report the synthesis and characterization of five new complexes with the general formula [Gd(H3bt)(carboxylate)]6, employing four different carboxylate ...
Ondřej František Fellner, Kamil Kotrle, Erik Čižmár, Jana Brázdová, Pavel Štarha, Ján Moncoľ, Radovan Herchel, Ivan Nemec   +7 more
wiley   +1 more source

Mature T‐cell leukemia/lymphoma with an NK‐like immunophenotype: A report of 7 cases

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Distinguishing T‐cell from NK‐cell neoplasms can occasionally be challenging, as neoplastic T cells can lose T‐cell markers such as surface CD3 (sCD3) and CD5 while acquiring NK‐cell markers such as CD16, CD56, and CD94. In this study, we present a series of 7 mature T‐cell lymphoma/leukemia cases with NK‐like immunophenotypes to clarify ...
Wei J. Wang, Sa A. Wang, Hong Fang, Jeffrey L. Jorgensen, Shimin Hu, Lianqun Qiu, Jie Xu, L. Jeffrey Medeiros, Wei Wang   +8 more
wiley   +1 more source

γδ T Cell‐mediated Tumor Immunity is Tightly Regulated by STING and TGF‐β Signaling Pathways

Advanced Science
The STING pathway plays a critical role in tumor immunosurveillance. However, the precise mechanisms by which STING regulates gamma delta (γδ) T cell function during tumor progression remain unclear.
Jing Luo, Shengli Wang, Quanli Yang, Qianqian Fu, Chuyun Zhu, Tao Li, Shuxian Yang, Yin Zhao, Rong Guo, Xiaosong Ben, Yuzhen Zheng, Sitao Li, Guang Yang, Hongru Zhang, Hui Xiao, Zhengfan Jiang, Nan Yan, Dieter Kabelitz, Guodong Sun, Zvi Granot, Ligong Lu, Fuping You, Jianlei Hao, Zhinan Yin   +23 more
doaj   +1 more source

The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System

Frontiers in Immunology, 2020
Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses.
Jin Wo, Feng Zhang, Zhizhong Li, Chenghong Sun, Wencai Zhang, Guodong Sun   +5 more
doaj   +1 more source

A természetes immunitás szabályozási zavarainak hatása a terhesség kimenetelére = The effect of disturbed regulation of innate immunity on the outcome of pregnancy [PDF]

, 2011
Ismert, hogy a terhesség egészséges kiviseléséhez az immunrendszer lokális aktivációja és a terhes méh trophoblaszt sejtjein kifejeződő magzati antigének felismerése szükséges.
Barakonyi, Aliz
core  

Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis [PDF]

, 2007
Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS).
Copeland, Esparza, Fitzgerald, Harbige, Harbige, Jones, Karpus, Laurence S. Harbige, Mohammad K. Sharief, Mokhtarian, Ovadia, Santambrogio, Selmaj, Serafina, Thompson, Thompson, Vartanian   +16 more
core   +2 more sources

Support‐Driven Hydrogen Migration Enhances Ammonia Decomposition in Direct Ammonia Protonic Ceramic Fuel Cells

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Enhanced hydrogen species migration enabled by FN/BZY catalyst mitigates intermediate accumulation and improves DA‐PCFC performance during ammonia decomposition. Ammonia, with its high hydrogen density and carbon‐free nature, serves as ideal fuel for direct ammonia protonic ceramic fuel cells (DA‐PCFCs).
Meijuan Fei, Shuai Wang, Zhaohui Cai, Dongliang Liu, Cheng Huang, Xixi Wang, Jie Miao, Huangang Shi, Chuan Zhou, Wei Zhou   +9 more
wiley   +1 more source