Results 81 to 90 of about 6,064 (187)

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, EarlyView.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Latent Neoehrlichia mikurensis Infections May Be Reactivated in Patients With B-Cell Lymphomas Treated With Rituximab. [PDF]

Immunology
Eight percent of this cohort of patients had a latent Neoehrlichia mikurensis infection. It was only the latently infected patients who had N. mikurensis‐specific T cells, not the matched B‐cell lymphoma patients without the infection. The T‐cell responses of latently infected patients included perforin‐expressing Th1 and CD8+ T cells that upregulated ...
Wass L, Lewerin C, Jaén-Luchoro D, Lingblom C, Wennerås C.   +4 more
europepmc   +2 more sources

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

gamma delta T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity

, 2020
Γδ T cells in human solid tumors remain poorly defined. Here, we describe molecular and functional analyses of T-cell receptors (TCR) from tumor-infiltrating γδ T lymphocytes (γδ TIL) that were in direct contact with tumor cells in breast cancer lesions ...
Straetemans, Trudy, Kuball, Jurgen, Villacorta Hidalgo, José, Bronsert, Peter, Terrizzi, Antonela R, Ravens, Sarina, Sebestyen, Zsolt, Küppers, Ralf, Follo, Marie, Schmitt-Graeff, Annette, Heise, Kerstin, Prinz, Immo, Fernando, Febilla, Frenkel, Felix E, Chudakov, Dmitriy M, Kock, Sylvia, Malkovsky, Miroslav, Janssen, Anke, Fisch, Paul, van Diest, Eline, Werner, Martin, van Dooremalen, Sanne F.J., Spierings, Eric, Beringer, Dennis X, Kasatskaya, Sofya A   +24 more
core  

A Green Amphoteric Surfactant Derived From Rapeseed Oil for Enhanced Oil Recovery From Carbonate Acidic Oil Reservoirs

Journal of Surfactants and Detergents, EarlyView.
The Green Amphoteric Surfactant Derived From Rapeseed Oil for Enhanced Oil Recovery From Carbonate Acidic Oil Reservoirs. ABSTRACT Surfactants with both positive and negative functional groups (amphoteric or zwitterionic) are particularly advantageous in acidic oil reservoirs because they remain stable under harsh chemical conditions, tolerate acidic ...
Iman Nowrouzi, Amir H. Mohammadi, Abbas Khaksar Manshad   +2 more
wiley   +1 more source

Recognition of Butyrophilin-family Members by gamma-delta T Cells

, 2021
Human gamma-delta (γδ) T cells can respond rapidly with cytotoxic responses to pathogenic infections and malignant cells. Although they are found at low numbers in peripheral blood, these might expand and constitute up to half of the total circulating T ...
Rigau Cortal, Marc
core  

Liquid Crystal Polymers as Intrinsically Magnetic and Programmable Soft Materials for Microrobotics

Small, EarlyView.
Liquid crystal polymers (LCPs) are proposed as intrinsically magnetic, programmable, soft materials for microrobotics. Magnetic torque‐driven manipulation of LCP microobjects is achieved and characterized in terms of the step‐out frequency, reaching ∼0.6 Hz in a ∼250 mT magnetic field. The orientation of LCP microobjects in the magnetic field and their
Alexandra Gruzdenko, Ignacio Becerra Osorio, Max de Sain, Albert P. H. J. Schenning, Jaap M. J. den Toonder, Michael G. Debije   +5 more
wiley   +1 more source

Organic and Inorganic Pollutants, Oxidative Stress Biomarkers, and Electrophoretic Protein Profiles in an Endangered Thresher Shark (Alopias vulpinus) From Southeastern Brazil: A Case Study

Environmental Toxicology, EarlyView.
ABSTRACT A comprehensive screening of different environmental contaminants (total metals, thermostable metal fractions associated with detoxification, and persistent organic pollutants) was conducted in an endangered common thresher shark (Alopias vulpinus ) individual incidentally captured in southeastern Brazil.
Sidney Fernandes Sales Junior, Amanda Pontes Lopes, Heloíse Martins de Souza, Regina Fonseca, Enrico Mendes Saggioro, Francielli Monteiro Casanova, Kamila Cezar Gramlich, Tatiana Dillenburg Saint'Pierre, Carlos German Massone, Renato Carreira, Rachel Ann Hauser‐Davis   +10 more
wiley   +1 more source

Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application

Journal of Immunology Research, 2018
γδ T cells, a subgroup of T cells based on the γδ TCR, when compared with conventional T cells (αβ T cells), make up a very small proportion of T cells.
Yueshui Zhao, Ling Lin, Zhangang Xiao, Mingxing Li, Xu Wu, Wanping Li, Xiaobing Li, Qijie Zhao, Yuanlin Wu, Hanyu Zhang, Jianhua Yin, Lingling Zhang, Chi Hin Cho, Jing Shen   +13 more
doaj   +1 more source