Results 61 to 70 of about 1,803,893 (333)

γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer

Nature Reviews. Cancer, 2019
The potential of cancer immunotherapy relies on the mobilization of immune cells capable of producing antitumour cytokines and effectively killing tumour cells.
B. Silva‐Santos, Sofia Mensurado, S. Coffelt   +2 more
semanticscholar   +1 more source

A monoclonal antibody against T-cell receptor αβ induces endogenous cytokines and prevents mice from a lethal infection withListeria monocytogenes [PDF]

FEMS Immunology & Medical Microbiology, 1995
In vivo induction of cytokines by a monoclonal antibody (mAb) against T-cell receptor (TCR) alpha beta and the protective effect induced by the mAb on a lethal infection with Listeria monocytogenes were studied. Injection of anti-TCR alpha beta mAb induced rapid production of endogenous tumour necrosis factor in the spleens, and gamma interferon and ...
A, Nakane, S, Nishikawa, S, Sasaki, T, Miura, M, Asano, M, Kohanawa, T, Minagawa   +6 more
openaire   +2 more sources

Preclinical platforms to study therapeutic efficacy of human γδ T cells

Clinical and Translational Medicine, 2022
Background Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell therapy, however, their treatment efficacy is not satisfactory.
Lingling Ou, Huaishan Wang, Hui Huang, Zhiyan Zhou, Qiang Lin, Yeye Guo, Tara Mitchell, Alexander C. Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Wei Guo, Joseph Salvino, Meenhard Herlyn, Xiaowei Xu   +14 more
doaj   +1 more source

Single-cell differentiation trajectories define early stages of a human cutaneous T-cell lymphoma

Exploration of Immunology, 2022
Aim: The aim of this article is to characterize in detail the γδ T lymphocytes from an adult patient with primary cutaneous T-cell lymphoma of γδ subtype (γδ CTCL). Methods: Here this article reports trajectory mapping on high-resolution differentiation
Juan-Pablo Cerapio, Marion Perrier, Fréderic Pont, Camille Laurent, Stéphane Bertani, Jean-Jacques Fournie   +5 more
doaj   +1 more source

Characteristics and significance of γδ T cells in colorectal cancer. [PDF]

Oncoimmunology
Gamma-delta T cells are a subset of T cells that have features of both innate and adaptive immunity. Their role in cancer remains controversial, since both anti- and protumor functions have been reported.
Karjalainen H, Härkönen J, Sirniö P, Elomaa H, Äijälä VK, Kastinen M, Tapiainen VV, Väyrynen SA, Ahtiainen M, Helminen O, Wirta EV, Rintala J, Meriläinen S, Saarnio J, Rautio T, Seppälä TT, Böhm J, Mecklin JP, Tuomisto A, Mäkinen MJ, Väyrynen JP.   +20 more
europepmc   +2 more sources

A Novel Prothrombotic Pathway in Systemic Sclerosis Patients: Possible Role of Bisphosphonate-Activated γδ T Cells [PDF]

Frontiers in Immunology, 2014
Infusions of aminobisphonates (ABP) activate Vγ9δ2T cells in vivo and induce an acute inflammatory response in 30% of patients treated for osteoporosis. Following the observation of digital thrombosis in a systemic sclerosis (SSc) patient after treatment with an intravenous ABP, zoledronate (Zol), we evaluated whether patient and control peripheral ...
Victoria eMarcu-Malina, Alexandra eBalbir-Gurman, Rima eDardik, Yolanda eBraun-Moscovici, Michael eSegel, Ilan eBank, Ilan eBank   +6 more
openaire   +3 more sources

Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells

Frontiers in Immunology, 2018
Epithelial and mucosal barriers are critical interfaces physically separating the body from the outside environment and are the tissues most exposed to microorganisms and potential inflammatory agents.
Camille Khairallah, Timothy H. Chu, Brian S. Sheridan   +2 more
doaj   +1 more source

Pathogen-Specific Immune Fingerprints during Acute Infection: The Diagnostic Potential of Human γδ T-Cells [PDF]

Frontiers in Immunology, 2014
The last 200 years have seen a dramatic reduction in the prevalence and severity of microbial infections, due to the implementation of groundbreaking measures ranging from improved sanitation and hygiene and the introduction of aseptic techniques to the development of successful vaccines and the discovery of effective antibiotics.
Matthias eEberl, Ida M Friberg, Anna Rita eLiuzzi, Matt P Morgan, Matt P Morgan, Nicholas eTopley   +5 more
openaire   +4 more sources

Distribution and functions of γδ T cells infiltrated in the ovarian cancer microenvironment

Journal of Translational Medicine, 2019
Background The role of γδ T cells, innate-like lymphocytes with unrestrained MHC, in various malignancies has recently been extensively studied. However, there is limited research regarding γδ T cells in ovarian cancer (OC) patients.
Xian Chen, Wenwen Shang, Rui Xu, Ming Wu, Xiaojie Zhang, Peijun Huang, Fang Wang, Shiyang Pan   +7 more
doaj   +1 more source

Six-of-the-best: unique contributions of γδ T cells to immunology

Nature reviews. Immunology, 2013
γδ T cells are a unique and conserved population of lymphocytes that have been the subject of a recent explosion of interest owing to their essential contributions to many types of immune response and immunopathology.
P. Vantourout, A. Hayday
semanticscholar   +1 more source