Results 31 to 40 of about 29,353 (245)

The co-stimulatory effects of MyD88-dependent Toll-like receptor signaling on activation of murine γδ T cells. [PDF]

PLoS ONE, 2014
γδ T cells express several different toll-like receptor (TLR)s. The role of MyD88- dependent TLR signaling in TCR activation of murine γδ T cells is incompletely defined. Here, we report that Pam3CSK4 (PAM, TLR2 agonist) and CL097 (TLR7 agonist), but not
Jinping Zhang, Jia Wang, Lan Pang, Guorui Xie, Thomas Welte, Vandana Saxena, Jason Wicker, Brian Mann, Lynn Soong, Alan Barrett, Willi Born, Rebecca O'Brien, Tian Wang   +12 more
doaj   +1 more source

Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation [PDF]

Frontiers in Immunology, 2015
The contributions of γδ T-cells to immunity to infection or tumors critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells. These processes are molecularly controlled by surface receptors that capture key extracellular cues and convey downstream intracellular ...
Ribeiro, Sérgio T, Ribot, Julie, Silva-Santos, Bruno   +2 more
openaire   +4 more sources

High level expression of A2ARs is required for the enhancing function, but not for the inhibiting function, of γδ T cells in the autoimmune responses of EAU.

PLoS ONE, 2018
We previously reported that activated γδ T cells greatly enhance autoimmune responses, particularly the Th17 response. To determine the mechanisms involved, we made a series of comparisons between activated and non-activated γδ T cells.
Dongchun Liang, Hui Shao, Willi K Born, Rebecca L O'Brien, Henry J Kaplan, Deming Sun   +5 more
doaj   +1 more source

Tumor vaccine based on extracellular vesicles derived from γδ‐T cells exerts dual antitumor activities

Journal of Extracellular Vesicles, 2023
γδ‐T cells are innate‐like T cells with dual antitumor activities. They can directly eradicate tumor cells and function as immunostimulatory cells to promote antitumor immunity.
Xiwei Wang, Yanmei Zhang, Yuet Chung, Chloe Ran Tu, Wenyue Zhang, Xiaofeng Mu, Manni Wang, Godfrey Chi‐Fung Chan, Wing‐Hang Leung, Yu‐Lung Lau, Yinping Liu, Wenwei Tu   +11 more
doaj   +1 more source

Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands

OncoImmunology, 2022
Adoptive transfer of γδ T cells is a novel immunotherapeutic approach to glioblastoma. Few recent studies have shown the efficacy of γδ T cells against glioblastoma, but no previous studies have identified the ligand–receptor interactions between γδ T ...
Haeyoun Choi, Yunkyung Lee, Soon A Park, Ji Hyeon Lee, Junseong Park, Jang Hyun Park, Heung Kyu Lee, Tai-Gyu Kim, Sin-Soo Jeun, Stephen Ahn   +9 more
doaj   +1 more source

Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells [PDF]

Frontiers in Immunology, 2014
Lymphocytes of the gamma delta (γδ) T-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. γδ T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoid cells.
Vasileios eBekiaris, Vasileios eBekiaris, John S Šedý, Carl F Ware   +3 more
openaire   +3 more sources

Human Vδ2+ γδ T Cells Differentially Induce Maturation, Cytokine Production, and Alloreactive T Cell Stimulation by Dendritic Cells and B Cells [PDF]

Frontiers in Immunology, 2014
Human γδ T cells expressing the Vγ9Vδ2 T cell receptor can induce maturation of dendritic cells (DC) into antigen-presenting cells (APC) and B cells into antibody-secreting plasma cells. Since B cells are capable of presenting antigens to T cells, we investigated if Vγ9Vδ2 T cells can influence antigen-presentation by these cells. We report that Vγ9Vδ2
Doherty, Derek, Phelan, Andreea
openaire   +5 more sources

A monoclonal antibody against T-cell receptor αβ induces endogenous cytokines and prevents mice from a lethal infection withListeria monocytogenes [PDF]

FEMS Immunology & Medical Microbiology, 1995
In vivo induction of cytokines by a monoclonal antibody (mAb) against T-cell receptor (TCR) alpha beta and the protective effect induced by the mAb on a lethal infection with Listeria monocytogenes were studied. Injection of anti-TCR alpha beta mAb induced rapid production of endogenous tumour necrosis factor in the spleens, and gamma interferon and ...
A, Nakane, S, Nishikawa, S, Sasaki, T, Miura, M, Asano, M, Kohanawa, T, Minagawa   +6 more
openaire   +2 more sources

Expanded Human Blood-Derived γδT Cells Display Potent Antigen-Presentation Functions [PDF]

Frontiers in Immunology, 2014
Cell-based immunotherapy strategies target tumors directly (via cytolytic effector cells) or aim at mobilizing endogenous anti-tumor immunity. The latter approach includes dendritic cells (DC) most frequently in the form of in vitro cultured peripheral blood monocytes-derived DC.
M. W. A. Khan, S. M. Curbishley, H. Chen, A. D. Thomas, H. Pircher, D. Mavilio, N. M. Steven, M. Eberl, B. Moser   +8 more
openaire   +4 more sources

Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells

Frontiers in Immunology, 2018
Epithelial and mucosal barriers are critical interfaces physically separating the body from the outside environment and are the tissues most exposed to microorganisms and potential inflammatory agents.
Camille Khairallah, Timothy H. Chu, Brian S. Sheridan   +2 more
doaj   +1 more source