Results 31 to 40 of about 1,803,893 (333)
The Jekyll and Hyde story of IL17-Producing γδT Cells [PDF]
Frontiers in Immunology, 2015 In comparison to conventional αβT cells, γδT cells are considered as specialized T cells based on their contributions in regulating immune response. γδT cells sense early environmental signals and initiate local immune-surveillance. The development of functional subtypes of γδT cells takes place in the thymus but they also exhibit plasticity in ...
Patil, Rushikesh S. +3 more
openaire +2 more sources
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells
Cell, 2019 Summary Lung cancer is closely associated with chronic inflammation, but the causes of inflammation and the specific immune mediators have not been fully elucidated.
C. Jin +15 more
semanticscholar +1 more source
Gamma Delta T Cells (γδ T Cells) in Health and Disease: In Memory of Professor Wendy Havran [PDF]
, 2020 Gamma delta (γδ) T cells are a small subset of CD3-positive T cells in the peripheral blood but occur at increased frequency in mucosal tissues [...]
Dieter Kabelitz, Kabelitz, Dietrich
core +1 more source
γδ T Cells in HIV Disease: Past, Present, and Future [PDF]
Frontiers in Immunology, 2015 Human immunodeficiency virus (HIV) type 1 dysregulates γδ T cells as part of an immune evasion mechanism. Nearly three decades of research defined the effects of HIV on γδ T cells and how this impacts disease. With highly effective antiretroviral therapy providing virus suppression and longer survival, we expected a return to normal for γδ T cells ...
Pauza, C. David +4 more
openaire +3 more sources
Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer
Signal Transduction and Targeted Therapy, 2023 γδ T cells have the unique ability to detect a wide range of tumors with low mutation burdens, making them attractive candidates for CAR-T-cell therapy.
Yue Wang +8 more
semanticscholar +1 more source
γδ T cells as early sensors of tissue damage and mediators of secondary neurodegeneration [PDF]
Frontiers in Cellular Neuroscience, 2014 Spontaneous or medically induced reperfusion occurs in up to 70% of patients within 24 h after cerebral ischemia. Reperfusion of ischemic brain tissue can augment the inflammatory response that causes additional injury. Recently, T cells have been shown to be an essential part of the post-ischemic tissue damage, and especially IL-17 secreting T cells ...
Gelderblom, Mathias +2 more
openaire +3 more sources
Frontiers in Immunology, 2018 T lymphocytes expressing the γδ T cell receptor (γδ TCR) can recognize antigens expressed by tumor cells and subsequently kill these cells. γδ T cells are indeed used in cancer immunotherapy clinical trials.
Claudia Juraske +30 more
doaj +1 more source
γδ T Cells in the Tumor Microenvironment—Interactions With Other Immune Cells
Frontiers in Immunology, 2022 A growing number of studies have shown that γδ T cells play a pivotal role in mediating the clearance of tumors and pathogen-infected cells with their potent cytotoxic, cytolytic, and unique immune-modulating functions.
K. Chan +3 more
semanticscholar +1 more source
Potential Use of γδ T Cell-Based Vaccines in Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2014 IMMUNOTHERAPY IS A FAST ADVANCING METHODOLOGY INVOLVING ONE OF TWO APPROACHES: (1) compounds targeting immune checkpoints and (2) cellular immunomodulators. The latter approach is still largely experimental and features in vitro generated, live immune effector cells, or antigen-presenting cells.
Khan, Mohd Wajid A. +2 more
openaire +3 more sources
Frontiers in Immunology, 2019 Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional ...
Irene M. Rodríguez-Gómez +13 more
doaj +1 more source