Generation and first characterization of TRDC-knockout pigs lacking γδ T cells [PDF]
Scientific Reports, 2021 The TRDC-locus encodes the T cell receptor delta constant region, one component of the γδ T cell receptor which is essential for development of γδ T cells.
Bjoern Petersen +9 more
doaj +2 more sources
γδ T cell mediated immune responses in Disease and Therapy [PDF]
Frontiers in Immunology, 2014 The role of γδ T cells in immunotherapy has gained specific importance in the recent years because of their prominent function involving directly or indirectly in the rehabilitation of the diseases. γδ T cells represent a minor population of T cells that
Sree Latha eT +6 more
doaj +3 more sources
The interaction of dendritic cells and γδ T cells promotes the activation of γδ T cells in experimental autoimmune uveitis [PDF]
Journal of Innovative Optical Health Sciences, 2017 Uveitis is a severe inflammatory disease that can cause visual impairment. Recently, activated γδ T cells were proved to play a central role in the development of experimental autoimmune uveitis (EAU).
Beibei Wang +4 more
doaj +2 more sources
γδ T cell-mediated antibody-dependent cellular cytotoxicity with CD19 antibodies assessed by an impedance-based label-free real-time cytotoxicity assay [PDF]
Frontiers in Immunology, 2014 γδ T cells are not MHC restricted, elicit cytotoxicity against various malignancies, are present in early post-transplant phases in novel stem cell transplantation (SCT) strategies and have been shown to mediate antibody-dependent cellular cytotoxicity ...
Ursula Jördis Eva Seidel +10 more
doaj +3 more sources
γδ T cells confer protection against murine cytomegalovirus (MCMV). [PDF]
PLoS Pathogens, 2015 Cytomegalovirus (CMV) is a leading infectious cause of morbidity in immune-compromised patients. γδ T cells have been involved in the response to CMV but their role in protection has not been firmly established and their dependency on other lymphocytes ...
Camille Khairallah +13 more
doaj +2 more sources
IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis [PDF]
, 2023 BACKGROUND: Elicitation of allergic contact dermatitis (ACD), an inflammatory type 4 hypersensitivity disease, induces skin infiltration by polyclonal effector CD8 αβ T cells and precursors of tissue-resident memory T (TRM) cells.
Llorian, Miriam +33 more
core +1 more source
Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses
Nature Immunology, 2023 Kamiya and colleagues examine the effects of chronic social-defeat stress on the intestinal microbiome and show a pathological role played by dectin-1 and interleukin-17 expressed by gut γδ T cells on this behavioral vulnerability.
Xiaolei Zhu +18 more
semanticscholar +1 more source
Clinical & Translational Immunology, 2022 Autologous chimeric antigen receptor (CAR) αβ T‐cell therapies have demonstrated remarkable antitumor efficacy in patients with haematological malignancies; however, not all eligible cancer patients receive clinical benefit.
K. Nishimoto +27 more
semanticscholar +1 more source
Cell Reports, 2021 Gut interleukin-17A (IL-17)-producing γδ T cells are tissue-resident cells that are involved in both host defense and regulation of intestinal inflammation. However, factors that regulate their functions are poorly understood. In this study, we find that
L. Dupraz +15 more
semanticscholar +1 more source
Monitoring Circulating γδ T Cells in Cancer Patients to Optimize γδ T Cell-Based Immunotherapy [PDF]
Frontiers in Immunology, 2014 The success of γδ T cell-based immunotherapy, where the cytotoxic activity of circulating γδ T lymphocytes is activated by nitrogen-containing bisphosphonates (n-BP), or possibly by bispecific antibodies or the combination of both, requires a profound knowledge of patients' γδ T cells.
Oberg, Hans-Heinrich +7 more
openaire +3 more sources