Results 11 to 20 of about 31,357 (216)

Expression of T-Bet, Eomesodermin, and GATA-3 Correlates With Distinct Phenotypes and Functional Properties in Porcine γδ T Cells

Frontiers in Immunology, 2019
Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional ...
Irene M. Rodríguez-Gómez, Stephanie C. Talker, Tobias Käser, Maria Stadler, Lisa Reiter, Andrea Ladinig, Jemma V. Milburn, Jemma V. Milburn, Sabine E. Hammer, Kerstin H. Mair, Kerstin H. Mair, Armin Saalmüller, Wilhelm Gerner, Wilhelm Gerner   +13 more
doaj   +1 more source

Double-edged sword: γδ T cells in mucosal homeostasis and disease

Experimental and Molecular Medicine, 2023
The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in direct contact with pathogens, and γδ T cells perform various roles in the tissue. γδ T cells efficiently
In Kang, Yumin Kim, Heung Kyu Lee
doaj   +1 more source

Generation and first characterization of TRDC-knockout pigs lacking γδ T cells

Scientific Reports, 2021
The TRDC-locus encodes the T cell receptor delta constant region, one component of the γδ T cell receptor which is essential for development of γδ T cells.
Bjoern Petersen, Robert Kammerer, Antje Frenzel, Petra Hassel, Tung Huy Dau, Roswitha Becker, Angele Breithaupt, Reiner Georg Ulrich, Andrea Lucas-Hahn, Gregor Meyers   +9 more
doaj   +1 more source

Activation status of γδ T cells dictates their effect on osteoclast generation and bone resorption

Bone Reports, 2015
γδ T cells, a small subset of T cell population (5–10%), forms a bridge between innate and adaptive immunity. Although the role of γδ T cells in infectious diseases and antitumor immunity is well investigated, their role in bone biology needs to be ...
Swati P. Phalke, Shubhada V. Chiplunkar
doaj   +1 more source

High level expression of A2ARs is required for the enhancing function, but not for the inhibiting function, of γδ T cells in the autoimmune responses of EAU.

PLoS ONE, 2018
We previously reported that activated γδ T cells greatly enhance autoimmune responses, particularly the Th17 response. To determine the mechanisms involved, we made a series of comparisons between activated and non-activated γδ T cells.
Dongchun Liang, Hui Shao, Willi K Born, Rebecca L O'Brien, Henry J Kaplan, Deming Sun   +5 more
doaj   +1 more source

Tumor vaccine based on extracellular vesicles derived from γδ‐T cells exerts dual antitumor activities

Journal of Extracellular Vesicles, 2023
γδ‐T cells are innate‐like T cells with dual antitumor activities. They can directly eradicate tumor cells and function as immunostimulatory cells to promote antitumor immunity.
Xiwei Wang, Yanmei Zhang, Yuet Chung, Chloe Ran Tu, Wenyue Zhang, Xiaofeng Mu, Manni Wang, Godfrey Chi‐Fung Chan, Wing‐Hang Leung, Yu‐Lung Lau, Yinping Liu, Wenwei Tu   +11 more
doaj   +1 more source

Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands

OncoImmunology, 2022
Adoptive transfer of γδ T cells is a novel immunotherapeutic approach to glioblastoma. Few recent studies have shown the efficacy of γδ T cells against glioblastoma, but no previous studies have identified the ligand–receptor interactions between γδ T ...
Haeyoun Choi, Yunkyung Lee, Soon A Park, Ji Hyeon Lee, Junseong Park, Jang Hyun Park, Heung Kyu Lee, Tai-Gyu Kim, Sin-Soo Jeun, Stephen Ahn   +9 more
doaj   +1 more source

The co-stimulatory effects of MyD88-dependent Toll-like receptor signaling on activation of murine γδ T cells. [PDF]

PLoS ONE, 2014
γδ T cells express several different toll-like receptor (TLR)s. The role of MyD88- dependent TLR signaling in TCR activation of murine γδ T cells is incompletely defined. Here, we report that Pam3CSK4 (PAM, TLR2 agonist) and CL097 (TLR7 agonist), but not
Jinping Zhang, Jia Wang, Lan Pang, Guorui Xie, Thomas Welte, Vandana Saxena, Jason Wicker, Brian Mann, Lynn Soong, Alan Barrett, Willi Born, Rebecca O'Brien, Tian Wang   +12 more
doaj   +1 more source

Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells

Frontiers in Immunology, 2018
Epithelial and mucosal barriers are critical interfaces physically separating the body from the outside environment and are the tissues most exposed to microorganisms and potential inflammatory agents.
Camille Khairallah, Timothy H. Chu, Brian S. Sheridan   +2 more
doaj   +1 more source

A close look at current γδ T-cell immunotherapy

Frontiers in Immunology, 2023
Owing to their antitumor and major histocompatibility complex (MHC)-independent capacities, γδ T cells have gained popularity in adoptive T-cell immunotherapy in recent years. However, many unknowns still exist regarding γδ T cells, and few clinical data
Ling Ma, Ling Ma, Yanmin Feng, Zishan Zhou   +3 more
doaj   +1 more source