Results 11 to 20 of about 29,353 (245)
γδ T cell mediated immune responses in Disease and Therapy [PDF]
Frontiers in Immunology, 2014 The role of γδ T cells in immunotherapy has gained specific importance in the recent years because of their prominent function involving directly or indirectly in the rehabilitation of the diseases. γδ T cells represent a minor population of T cells that
Sree Latha eT +6 more
doaj +3 more sources
γδ T cell-mediated antibody-dependent cellular cytotoxicity with CD19 antibodies assessed by an impedance-based label-free real-time cytotoxicity assay [PDF]
Frontiers in Immunology, 2014 γδ T cells are not MHC restricted, elicit cytotoxicity against various malignancies, are present in early post-transplant phases in novel stem cell transplantation (SCT) strategies and have been shown to mediate antibody-dependent cellular cytotoxicity ...
Ursula Jördis Eva Seidel +10 more
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Monitoring Circulating γδ T Cells in Cancer Patients to Optimize γδ T Cell-Based Immunotherapy [PDF]
Frontiers in Immunology, 2014 The success of γδ T cell-based immunotherapy, where the cytotoxic activity of circulating γδ T lymphocytes is activated by nitrogen-containing bisphosphonates (n-BP), or possibly by bispecific antibodies or the combination of both, requires a profound knowledge of patients' γδ T cells.
Oberg, Hans-Heinrich +7 more
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An increased number of circulating γ/δ TCR + T cells in patients with chronic viral hepatitis [PDF]
FEMS Immunology & Medical Microbiology, 1995 Abstract There is evidence that γ δ TCR + T cells are specialized in recognizing different antigens, but their immunologic role as a second TCR is still unclear. The aim of this study was to investigate the percentage and absolute numbers of circulating γ δ TCR + T cells in patients with chronic viral hepatitis (CVH) and to compare with
Vassiliki Nikolopoulou +4 more
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A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans
Journal of Experimental Medicine, 2020 T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR–mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to
Sarah C. Edwards +26 more
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Plasticity of γδ T Cells: Impact on the Anti-Tumor Response [PDF]
Frontiers in Immunology, 2014 The tumor immune microenvironment contributes to tumor initiation, progression, and response to therapy. Among the immune cell subsets that play a role in the tumor microenvironment, innate-like T cells that express T cell receptors composed of γ and δ chains (γδ T cells) are of particular interest.
Lafont, Virginie +6 more
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Multiple Receptor-Ligand Interactions Direct Tissue-Resident γδ T Cell Activation [PDF]
Frontiers in Immunology, 2014 γδ T cells represent a major T cell population in epithelial tissues, such as skin, intestine, and lung, where they function in maintenance of the epithelium and provide a crucial first line defense against environmental and pathogenic insults. Despite their importance, the molecular mechanisms directing their activation and function have remained ...
Witherden, Deborah. A. +2 more
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γδ T Cells in HIV Disease: Past, Present, and Future [PDF]
Frontiers in Immunology, 2015 Human immunodeficiency virus (HIV) type 1 dysregulates γδ T cells as part of an immune evasion mechanism. Nearly three decades of research defined the effects of HIV on γδ T cells and how this impacts disease. With highly effective antiretroviral therapy providing virus suppression and longer survival, we expected a return to normal for γδ T cells ...
Pauza, C. David +4 more
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γδ T Lymphocytes in the Diagnosis of Human T Cell Receptor Immunodeficiencies [PDF]
Frontiers in Immunology, 2015 Human T cell receptor (TCR) immunodeficiencies (TCRID) are rare autosomal recessive disorders caused by mutations affecting TCR, CD3, or CD247 chains, which share developmental, functional, and TCR expression defects (1). Their rapid diagnosis is fundamental for patient survival and early hematopoietic stemcell transplantation.Here,we propose that ...
Garcillan, B +10 more
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Frontiers in Immunology, 2018 T lymphocytes expressing the γδ T cell receptor (γδ TCR) can recognize antigens expressed by tumor cells and subsequently kill these cells. γδ T cells are indeed used in cancer immunotherapy clinical trials.
Claudia Juraske +30 more
doaj +1 more source