Results 21 to 30 of about 31,357 (216)

Preclinical platforms to study therapeutic efficacy of human γδ T cells

Clinical and Translational Medicine, 2022
Background Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell therapy, however, their treatment efficacy is not satisfactory.
Lingling Ou, Huaishan Wang, Hui Huang, Zhiyan Zhou, Qiang Lin, Yeye Guo, Tara Mitchell, Alexander C. Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Wei Guo, Joseph Salvino, Meenhard Herlyn, Xiaowei Xu   +14 more
doaj   +1 more source

Gamma-delta (γδ) T cells: friend or foe in cancer development?

Journal of Translational Medicine, 2018
Background γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity.
Yijing Zhao, Chao Niu, Jiuwei Cui
doaj   +1 more source

Obesity impairs γδ T cell homeostasis and antiviral function in humans. [PDF]

PLoS ONE, 2015
Obese patients are susceptible to increased morbidity and mortality associated with infectious diseases such as influenza A virus. γδ T cells and memory αβ T cells play key roles in reducing viral load by rapidly producing IFN-γ and lysing infected cells.
Anne E Costanzo, Kristen R Taylor, Shelley Dutt, Peggy P Han, Ken Fujioka, Julie M Jameson   +5 more
doaj   +1 more source

Distribution and functions of γδ T cells infiltrated in the ovarian cancer microenvironment

Journal of Translational Medicine, 2019
Background The role of γδ T cells, innate-like lymphocytes with unrestrained MHC, in various malignancies has recently been extensively studied. However, there is limited research regarding γδ T cells in ovarian cancer (OC) patients.
Xian Chen, Wenwen Shang, Rui Xu, Ming Wu, Xiaojie Zhang, Peijun Huang, Fang Wang, Shiyang Pan   +7 more
doaj   +1 more source

Human γδ T Cells Augment Antigen Presentation in Listeria Monocytogenes Infection

Molecular Medicine, 2016
Circulating γδ T cells In healthy Individuals rapidly respond to bacterial and viral pathogens. Many studies have demonstrated that γδ T cells are activated and expanded by Listeria monocytogenes (L.
Yuli Zhu, Huaishan Wang, Yi Xu, Yu Hu, Hui Chen, Lianxian Cui, Jianmin Zhang, Wei He   +7 more
doaj   +1 more source

Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation.

PLoS ONE, 2013
Gammadelta (γδ) T lymphocytes respond quickly upon antigen encounter to produce a cytokine response. In this study, we sought to understand how functions of γδ T cells are differentially regulated compared to αβ T cells.
Hsin-Yuan Cheng, Runpei Wu, Abraham K Gebre, Richard N Hanna, Dan J Smith, John S Parks, Klaus Ley, Catherine C Hedrick   +7 more
doaj   +1 more source

Single-cell differentiation trajectories define early stages of a human cutaneous T-cell lymphoma

Exploration of Immunology, 2022
Aim: The aim of this article is to characterize in detail the γδ T lymphocytes from an adult patient with primary cutaneous T-cell lymphoma of γδ subtype (γδ CTCL). Methods: Here this article reports trajectory mapping on high-resolution differentiation
Juan-Pablo Cerapio, Marion Perrier, Fréderic Pont, Camille Laurent, Stéphane Bertani, Jean-Jacques Fournie   +5 more
doaj   +1 more source

Porcine γδ T cells express cytotoxic cell-associated markers and display killing activity but are not selectively cytotoxic against PRRSV- or swIAV-infected macrophages

Frontiers in Immunology
BackgroundGamma-delta (γδ) T cells are a major immune cell subset in pigs. Approximately 50% of circulating T cells are γδ T cells in young pigs and up to 30% in adult sows.
Leonie Bettin, Leonie Bettin, Joseph Darbellay, Jill van Kessel, Neeraj Dhar, Neeraj Dhar, Neeraj Dhar, Volker Gerdts, Volker Gerdts   +8 more
doaj   +1 more source

Infliximab induces clonal expansion of γδ-T cells in Crohn's disease: a predictor of lymphoma risk? [PDF]

PLoS ONE, 2011
BackgroundConcominant with the widespread use of combined immunotherapy in the management of Crohn's disease (CD), the incidence of hepato-splenic gamma-delta (γδ)-T cell lymphoma has increased sharply in CD patients.
Jens Kelsen, Anders Dige, Heinrich Schwindt, Francesco D'Amore, Finn S Pedersen, Jørgen Agnholt, Lisbet A Christensen, Jens F Dahlerup, Christian L Hvas   +8 more
doaj   +1 more source

Hepatocellular carcinoma‐infiltrating γδ T cells are functionally defected and allogenic Vδ2+ γδ T cell can be a promising complement

Clinical and Translational Medicine, 2022
In hepatocellular carcinoma (HCC), γδ T cells participate in mediating the anti‐tumour response and are linked with a positive prognosis. However, these cells can become pro‐tumoural in the tumour microenvironment (TME).
Wenjing He, Yi Hu, Dan Chen, Yijia Li, Dongmei Ye, Qiang Zhao, Li Lin, Xiaomin Shi, Ligong Lu, Zhinan Yin, Xiaoshun He, Yifang Gao, Yangzhe Wu   +12 more
doaj   +1 more source