Results 21 to 30 of about 1,803,893 (333)

Function of γδ T cells in tumor immunology and their application to cancer therapy

Experimental and Molecular Medicine, 2021
T cells of the γδ lineage are unconventional T cells with functions not restricted to MHC-mediated antigen presentation. Because of their broad antigen specificity and NK-like cytotoxicity, γδ T-cell importance in tumor immunology has been emphasized ...
Jang Hyun Park, H. Lee
semanticscholar   +1 more source

An increased number of circulating γ/δ TCR + T cells in patients with chronic viral hepatitis [PDF]

FEMS Immunology & Medical Microbiology, 1995
Abstract There is evidence that γ δ TCR + T cells are specialized in recognizing different antigens, but their immunologic role as a second TCR is still unclear. The aim of this study was to investigate the percentage and absolute numbers of circulating γ δ TCR + T cells in patients with chronic viral hepatitis (CVH) and to compare with
Vassiliki Nikolopoulou, Athanasios Skoutelis, Konstantinos Thomopoulos, Bassam Salsaa, Nicholas Zoumbos   +4 more
openaire   +1 more source

IL-1β-activated mTORC2 promotes accumulation of IFN-γ+ γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis

Cell Death and Disease, 2022
Liver fibrosis represents a severe stage of liver damage, with hallmarks of inflammation, hepatic stellate cell activation, and extracellular matrix accumulation.
Qihui Liu, Quanli Yang, Zengfeng Wu, Yanfang Chen, Miaomiao Xu, Hua Zhang, Jiliang Zhao, Zonghua Liu, Zerong Guan, Jing Luo, Zhi-yong Li, Guodong Sun, Qiong Wen, Yan Xu, Zhenhua Li, Kebing Chen, Xiaosong Ben, Wanchun He, Xueshi Li, Zhinan Yin, Jianlei Hao, Ligong Lu   +21 more
doaj   +1 more source

Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function

Nature Immunology, 2023
γδ T cells contribute to cancer immunity by killing tumor cells, but their function in the context of immune checkpoint inhibition is less clear. Here the authors show that a Vδ2^− subset of γδ T cells in human kidney tumors phenotypically resembles ...
Chiara Rancan, Marcel Arias-Badia, P. Dogra, Brandon Chen, D. Aran, Hai Yang, Diamond Luong, A. Ilano, Jacky Y. Li, Hewitt Chang, S. Kwek, Li Zhang, L. Lanier, M. Meng, D. Farber, L. Fong   +15 more
semanticscholar   +1 more source

γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation. [PDF]

PLoS ONE, 2013
Both antigen recognition and CD28 costimulation are required for the activation of naïve αβ T cells and their subsequent differentiation into cytokine-producing or cytotoxic effectors.
Renee M Laird, Benjamin J Wolf, Michael F Princiotta, Sandra M Hayes   +3 more
doaj   +1 more source

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

Journal of Experimental Medicine, 2020
T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR–mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to
Sarah C. Edwards, Caroline E. Sutton, Kristin Ladell, Emma J. Grant, James E. McLaren, Fiona Roche, Pradyot Dash, Nopporn Apiwattanakul, Walid Awad, Kelly L. Miners, Stephen J. Lalor, Julie C. Ribot, Song Baik, Barry Moran, Aoife McGinley, Valerie Pivorunas, Lori Dowding, Michael Macoritto, Jesus Paez-Cortez, Anthony Slavin, Graham Anderson, Bruno Silva-Santos, Karsten Hokamp, David A. Price, Paul G. Thomas, Rachel M. McLoughlin, Kingston H.G. Mills   +26 more
openaire   +4 more sources

Plasticity of γδ T Cells: Impact on the Anti-Tumor Response [PDF]

Frontiers in Immunology, 2014
The tumor immune microenvironment contributes to tumor initiation, progression, and response to therapy. Among the immune cell subsets that play a role in the tumor microenvironment, innate-like T cells that express T cell receptors composed of γ and δ chains (γδ T cells) are of particular interest.
Lafont, Virginie, Sanchez, Françoise, Laprevotte, Emilie, Michaud, Henri-Alexandre, Gros, Laurent, Eliaou, Jean-François, Bonnefoy, Nathalie   +6 more
openaire   +2 more sources

Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation. [PDF]

PLoS ONE, 2013
Gammadelta (γδ) T lymphocytes respond quickly upon antigen encounter to produce a cytokine response. In this study, we sought to understand how functions of γδ T cells are differentially regulated compared to αβ T cells.
Hsin-Yuan Cheng, Runpei Wu, Abraham K Gebre, Richard N Hanna, Dan J Smith, John S Parks, Klaus Ley, Catherine C Hedrick   +7 more
doaj   +1 more source

γδ T Lymphocytes in the Diagnosis of Human T Cell Receptor Immunodeficiencies [PDF]

Frontiers in Immunology, 2015
Human T cell receptor (TCR) immunodeficiencies (TCRID) are rare autosomal recessive disorders caused by mutations affecting TCR, CD3, or CD247 chains, which share developmental, functional, and TCR expression defects (1). Their rapid diagnosis is fundamental for patient survival and early hematopoietic stemcell transplantation.Here,we propose that ...
Garcillan, B, Marin, AVM, Jimenez-Reinoso, A, Briones, AC, Munoz-Ruiz, M, Garcia-Leon, MJ, Gil, J, Allende, LM, Martinez-Naves, E, Toribio, ML, Regueiro, JR   +10 more
openaire   +7 more sources

NK-like CD8+ γδ T cells are expanded in persistent Mycobacterium tuberculosis infection and chronic inflammation

Science immunology, 2023
The response of gamma delta (γδ) T cells in the acute versus chronic phases of the same infection is unclear. How γδ T cells function in acute Mycobacterium tuberculosis (Mtb) infection is well characterized, but their response during persistent Mtb ...
Roshni Roy Chowdhury, John R. Valainis, M. Dubey, L. von Boehmer, E. Solà, J. Wilhelmy, Jing Guo, Oliver Kask, M. Ohanyan, Meng-Kun Sun, Huang Huang, Xianxi Huang, Patricia K. Nguyen, T. Scriba, Mark M. Davis, S. Bendall, Y. Chien   +16 more
semanticscholar   +1 more source