Results 21 to 30 of about 29,353 (245)

Potential Use of γδ T Cell-Based Vaccines in Cancer Immunotherapy [PDF]

Frontiers in Immunology, 2014
IMMUNOTHERAPY IS A FAST ADVANCING METHODOLOGY INVOLVING ONE OF TWO APPROACHES: (1) compounds targeting immune checkpoints and (2) cellular immunomodulators. The latter approach is still largely experimental and features in vitro generated, live immune effector cells, or antigen-presenting cells.
Khan, Mohd Wajid A., Eberl, Matthias, Moser, Bernhard   +2 more
openaire   +3 more sources

Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation [PDF]

Frontiers in Immunology, 2015
Despite effective anti-viral therapies, cytomegalovirus (CMV) is still associated with direct (CMV disease) and indirect effects (rejection and poor graft survival) in kidney transplant recipients. Recently, an unconventional T cell population (collectively designated as Vδ2(neg) γδ T cells) has been characterized during the anti-CMV immune response in
Couzi, Lionel, Pitard, Vincent, Moreau, Jean-François, Merville, Pierre, Déchanet-Merville, Julie   +4 more
openaire   +2 more sources

Expression of T-Bet, Eomesodermin, and GATA-3 Correlates With Distinct Phenotypes and Functional Properties in Porcine γδ T Cells

Frontiers in Immunology, 2019
Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional ...
Irene M. Rodríguez-Gómez, Stephanie C. Talker, Tobias Käser, Maria Stadler, Lisa Reiter, Andrea Ladinig, Jemma V. Milburn, Jemma V. Milburn, Sabine E. Hammer, Kerstin H. Mair, Kerstin H. Mair, Armin Saalmüller, Wilhelm Gerner, Wilhelm Gerner   +13 more
doaj   +1 more source

The Jekyll and Hyde story of IL17-Producing γδT Cells [PDF]

Frontiers in Immunology, 2015
In comparison to conventional αβT cells, γδT cells are considered as specialized T cells based on their contributions in regulating immune response. γδT cells sense early environmental signals and initiate local immune-surveillance. The development of functional subtypes of γδT cells takes place in the thymus but they also exhibit plasticity in ...
Patil, Rushikesh S., Bhat, Sajad A., Dar, Asif A., Chiplunkar, Shubhada V.   +3 more
openaire   +2 more sources

Double-edged sword: γδ T cells in mucosal homeostasis and disease

Experimental and Molecular Medicine, 2023
The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in direct contact with pathogens, and γδ T cells perform various roles in the tissue. γδ T cells efficiently
In Kang, Yumin Kim, Heung Kyu Lee
doaj   +1 more source

D-Mannose Suppresses γδ T Cells and Alleviates Murine Psoriasis

Frontiers in Immunology, 2022
Psoriasis is a chronic skin disorder associated with multiple sequelae, such as psoriatic arthritis and cardiovascular diseases. Increasing evidence has shown that γδ T cells, as sources of IL-17A, play critical roles in psoriatic inflammations. However,
Mingyang Li, Mingyang Li, Mingyang Li, Mingyang Li, Haiyan Cheng, Dan Tian, Dan Tian, Dan Tian, Dan Tian, Lu Yang, Lu Yang, Lu Yang, Xiaonan Du, Xiaonan Du, Xiaonan Du, Yuhualei Pan, Yuhualei Pan, Yuhualei Pan, Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang, Xueling Mei   +22 more
doaj   +1 more source

Cancer Immunotherapy Using γδT Cells: Dealing with Diversity [PDF]

Frontiers in Immunology, 2014
The broad and potent tumor-reactivity of innate-like γδT cells makes them valuable additions to current cancer immunotherapeutic concepts based on adaptive immunity, such as monoclonal antibodies and αβT cells. However, clinical success using γδT cells to treat cancer has so far fallen short.
Scheper, Wouter, Sebestyen, Zsolt, Kuball, Jürgen   +2 more
openaire   +3 more sources

Generation and first characterization of TRDC-knockout pigs lacking γδ T cells

Scientific Reports, 2021
The TRDC-locus encodes the T cell receptor delta constant region, one component of the γδ T cell receptor which is essential for development of γδ T cells.
Bjoern Petersen, Robert Kammerer, Antje Frenzel, Petra Hassel, Tung Huy Dau, Roswitha Becker, Angele Breithaupt, Reiner Georg Ulrich, Andrea Lucas-Hahn, Gregor Meyers   +9 more
doaj   +1 more source

γδ T cells as early sensors of tissue damage and mediators of secondary neurodegeneration [PDF]

Frontiers in Cellular Neuroscience, 2014
Spontaneous or medically induced reperfusion occurs in up to 70% of patients within 24 h after cerebral ischemia. Reperfusion of ischemic brain tissue can augment the inflammatory response that causes additional injury. Recently, T cells have been shown to be an essential part of the post-ischemic tissue damage, and especially IL-17 secreting T cells ...
Gelderblom, Mathias, Arunachalam, Priyadharshini, Magnus, Tim   +2 more
openaire   +3 more sources

Activation status of γδ T cells dictates their effect on osteoclast generation and bone resorption

Bone Reports, 2015
γδ T cells, a small subset of T cell population (5–10%), forms a bridge between innate and adaptive immunity. Although the role of γδ T cells in infectious diseases and antitumor immunity is well investigated, their role in bone biology needs to be ...
Swati P. Phalke, Shubhada V. Chiplunkar
doaj   +1 more source