Results 91 to 100 of about 40,728 (191)

Critical role of endothelial Notch1 signaling in postnatal angiogenesis [PDF]

, 2007
Notch receptors are important mediators of cell fate during embryogenesis, but their role in adult physiology, particularly in postnatal angiogenesis, remains unknown.
Gridley, T., Ii, M., Liao, J. K., Limbourg, F. P., Losordo, D. W., Mukai, Y., Radtke, F., Rikitake, Y., Satoh, M., Silver, M., Takeshita, K.   +10 more
core   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

Neurobiology of Disease, 2008
Alzheimer's disease (AD) is characterized by overproduction of Aβ derived from APP cleavage via β- and γ-secretase pathway. Recent evidence has linked altered cholesterol metabolism to AD pathogenesis. In this study, we show that AD brain had significant
Huaqi Xiong, Debbie Callaghan, Aimee Jones, Douglas G. Walker, Lih-Fen Lue, Thomas G. Beach, Lucia I. Sue, John Woulfe, Huaxi Xu, Danica B. Stanimirovic, Wandong Zhang   +10 more
doaj   +1 more source

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain [PDF]

, 2017
The deposition of amyloid-beta (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from the cleavage of C-terminal fragments of the amyloid precursor protein (APP-CTFs) by γ-secretase, an ...
Alattia, Jean-René, Dimitrov, Mitko, Fraering, Patrick C., Matz, Alexandre, Mosser, Sebastien, Pascual, Justine, Schneider, Bernard L.   +6 more
core  

Characterization of the γ-secretase subunit interactome in Arabidopsis thaliana [PDF]

, 2019
Gamma secretase is a multi-subunit complex with aspartic intramembrane protease activity that is involved in the pathogenesis of Alzheimer's disease in humans. In Arabidopsis thaliana, -secretase subunits are localized to endomembrane system compartments
De Jaeger, Geert, Gevaert, Kris, Krela, Rafal, Lesniewicz, Krzysztof, Skrzypczak, Tomasz, Van De Slijke, Eveline, Wadurkar, Shraddha, Wojtaszek, Przemyslaw   +7 more
core   +1 more source

Genomic and proteomic insights into hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou, Emmanouil Stylianakis, Isis Ricaño‐Ponce, Nick Keur, Theodora Kanni, Dimitra Stergianou, Mihai G. Netea, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis   +8 more
wiley   +1 more source

Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

Neurobiology of Disease, 2004
Generation of Aβ from the β-amyloid precursor protein (APP) requires a series of proteolytic processes, including an intramembranous cleavage catalyzed by an aspartyl protease, γ-secretase.
Jun Wang, Anne L Brunkan, Silva Hecimovic, Emily Walker, Alison Goate   +4 more
doaj   +1 more source

Correlating familial Alzheimer’s disease gene mutations with clinical phenotype [PDF]

, 2010
Alzheimer’s disease (AD) causes devastating cognitive impairment and an intense research effort is currently devoted to developing improved treatments for it.
Rossor, M.N., Ryan, N.S.
core   +1 more source

Selective amyloid-β lowering agents [PDF]

, 2012
The amyloid-\(\beta\) peptide (A\(\beta\)), implicated in the pathogenesis of Alzheimer's disease (AD), is produced through sequential proteolysis of the A\(\beta\) precursor protein (APP) by \(\beta\)- and \(\gamma\)-secretases. Thus, blocking either of
Michael S Wolfe, D Beher, DR Howlett, H Cai, Y Luo, M Willem, L Hong, AK Ghosh, MS Wolfe, R Kopan, GH Searfoss, GT Wong, S Weggen, S Weggen, Y Zhou, T Sato, TL Kukar, WJ Netzer, PC Fraering, P Bakshi   +19 more
core   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source