Results 111 to 120 of about 40,728 (191)
Association of active γ-secretase complex with lipid rafts
Journal of Lipid Research, 2005 Cholesterol has been implicated in the pathogenesis of Alzheimer's disease (AD). Although the underlying mechanisms are not yet clear, several studies have provided evidence for the involvement of cholesterol-rich lipid rafts in the production of amyloid
Yasuomi Urano +9 more
doaj +1 more source
Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway [PDF]
, 2017 Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule cell progenitors (GCPs) and its misregulation is linked to various disorders, including cerebellar cancer medulloblastoma.
BELLAVIA, Diana +13 more
core +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.ABSTRACT The incidence and mortality of pancreatic cancer are steadily increasing worldwide, and the disease is projected to become the second leading cause of cancer‐related deaths by 2030. Pancreatic tumorigenesis is driven by multiple genetic alterations, underscoring the need to elucidate the molecular mechanisms underlying pancreatic ...
Wei Yu +7 more
wiley +1 more source
Effects of hypertension and anti-hypertensive treatment on Aβ plaque load, Aβ–synthesising and –degrading enzymes in frontal cortex [PDF]
, 2016 Epidemiological data associate hypertension with a predisposition to Alzheimer’s disease (AD), and a number of postmortem and in vivo studies also demonstrate that hypertension increases amyloid-β (Aβ) pathology.
Ashby, Emma L +3 more
core +2 more sources
Psychobiotics and the microbiota–gut–brain axis: Emerging paradigms in mental health modulation
Experimental Physiology, Volume 111, Issue 5, Page 2449-2463, 1 May 2026.Abstract The global rise in mental health conditions has prompted interest in interventions that act beyond conventional psychopharmacology. Psychobiotics, broadly understood as live microorganisms or microbe‐derived products that interact with the microbiota–gut–brain axis, have been suggested to exert neuroactive effects through neural, immune ...
Amir Arsalan Ghahari +4 more
wiley +1 more source
The Scientific World Journal, 2012 Lipids play an important role as risk or protective factors in Alzheimer’s disease (AD). Previously it has been shown that plasmalogens, the major brain phospholipids, are altered in AD.
Tatjana L. Rothhaar +9 more
doaj +1 more source
ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.
PLoS ONE, 2016 ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between cholesterol level in the central nervous system and Alzheimer's disease has ...
Osamu Sano +9 more
doaj +1 more source
Notch signaling in serous ovarian cancer [PDF]
, 2014 Ovarian cancer is the most lethal of all gynecologic malignancies because women commonly present with advanced stage disease and develop chemotherapy refractory tumors.
Foster, Rosemary +4 more
core +1 more source
A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease [PDF]
, 2010 : INTRODUCTION: LY450139 (semagacestat) inhibits gamma-secretase, a key enzyme for generation of amyloid beta (Abeta), the peptide deposited in plaques in Alzheimer disease (AD).
Erik Portelius +6 more
core +1 more source
Neurobiology of Disease, 2009 Most of the Alzheimer's disease (AD)-linked mutations in amyloid precursor protein (APP), which cause abnormal production of β-amyloid (Aβ), are localized at the major β-secretase-and γ-secretase cleavage sites. In this study, using an APP-knockout mouse
Jianxin Tan +5 more
doaj +1 more source