Results 111 to 120 of about 26,551 (120)

ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons

EMBO Journal, 2010
Peer-Hendrik Kuhn, Huanhuan Wang, Bastian Dislich   +2 more
exaly  

A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis

Cell Research, 2010
Jian Zhao, Feifei Wang, Lan Ma
exaly  

Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ‐secretase modulators

EMBO Journal, 2019
Dieter Petit, Manuel Hitzenberger, Katarzyna Marta Zoltowska   +2 more
exaly  

Substrate specificity of γ-secretase and other intramembrane proteases

Cellular and Molecular Life Sciences, 2008
Charles R Sanders
exaly  

Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain

Proceedings of the National Academy of Sciences of the United States of America, 2016
David M Bolduc, Dennis J Selkoe, Michael S Wolfe   +2 more
exaly  

Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead

European Journal of Medicinal Chemistry, 2018
Devendra Kumar, Ankit Ganeshpurkar, Dileep Kumar   +2 more
exaly  

The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity

EMBO Journal, 2004
Christoph Kaether, Anja Capell, Dieter Edbauer   +2 more
exaly  

Endoplasmic reticulum retention of the γ‐secretase complex component Pen2 by Rer1

EMBO Reports, 2007
Christoph Kaether, Keiro Shirotani, Harald Steiner   +2 more
exaly  

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor

Cell Metabolism, 2018
Kyeongjin Kim, Ira J Goldberg, Mark J Graham   +2 more
exaly  

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

Progress in Neurobiology, 2012
Gael Barthet, Anastasios Georgakopoulos, Nikolaos K Robakis   +2 more
exaly