Silencing of δ‐aminolevulinic acid dehydratase via virus induced gene silencing promotes callose deposition in plant phloem [PDF]
Plant Signaling & Behavior, 2022 The δ-aminolevulinic acid dehydratase (ALAD) enzyme is an intermediate in the biosynthetic pathway of tetrapyrroles. It combines two δ‐aminolevulinic acid (δ‐ALA) molecules to form the pyrrole, porphobilinogen, an important precursor for plant pigments ...
Nabil Killiny +2 more
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Pharmacokinetic‐pharmacodynamic model of urinary δ‐aminolevulinic acid reduction after givosiran treatment in patients with acute hepatic porphyria [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2023 Givosiran, an RNA interference‐based therapeutic, is a recent addition to the limited treatment armamentarium for acute hepatic porphyria (AHP). As a small interfering RNA that is selectively taken up in the liver, both the mechanism and targeted ...
Jongtae Lee +2 more
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Research Note: Improvement of eggshell strength and intensity of brown eggshell color by dietary magnesium and δ-aminolevulinic acid supplementation in laying hens [PDF]
Poultry Science, 2022 : The objective of the current experiment was to investigate the effect of dietary magnesium (Mg) and δ-aminolevulinic acid (ALA) supplementation on productive performance and egg quality in laying hens.
Jong Hyuk Kim +3 more
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Metabolic engineering of microorganisms for the production of multifunctional non‐protein amino acids: γ‐aminobutyric acid and δ‐aminolevulinic acid [PDF]
Microbial Biotechnology, 2021 Summary Gamma‐aminobutyric acid (GABA) and delta‐aminolevulinic acid (ALA), playing important roles in agriculture, medicine and other fields, are multifunctional non‐protein amino acids with similar and comparable properties and biosynthesis pathways ...
Anping Su +5 more
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Derivative Matrix-Isopotential Synchronous Spectrofluorimetry and Hantzsch Reaction: A Direct Route to Simultaneous Determination of Urinary δ-Aminolevulinic Acid and Porphobilinogen [PDF]
Frontiers in Chemistry, 2022 Early and sensitive detection of δ-aminolevulinic acid (δ-ALA) and porphobilinogen (PBG) is the cornerstone of diagnosis and effective treatment for acute porphyria. However, at present, the quantifying strategies demand multiple solvent extraction steps
Muhammad Ajmal +5 more
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Effects of the δ-aminolevulinic acid dehydratase polymorphism rs1800435 on blood lead levels: a new systematic review and meta-analysis [PDF]
Scientific ReportsExposure to lead has various health effects. Studies have correlated the δ-aminolevulinic acid dehydratase (ALAD) polymorphism rs1800435 (ALAD1 and ALAD2) with blood lead levels, but the results have been inconsistent.
Jiukun Jiang, Xiujing Xie
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Effects of δ‐aminolevulinic acid dehydratase silencing on the primary and secondary metabolisms of citrus [PDF]
Plant Direct, 2018 δ‐aminolevulinic acid dehydratase (ALAD) is an important enzyme in tetrapyrrole synthesis. ALAD combines two δ‐aminolevulinic acid (δ‐ALA) molecules to form the pyrrole molecule, porphobilinogen, an important precursor for plant pigments involved in ...
Nabil Killiny +4 more
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A versatile δ-aminolevulinic acid (ΑLA)-cyclodextrin bimodal conjugate-prodrug for PDT applications with the help of intracellular chemistry [PDF]
Beilstein Journal of Organic Chemistry, 2014 Grafting of δ-aminolevulinic acid (1) moieties on the narrow periphery of a β-cyclodextrin (β-CD) derivative through hydrolysable bonds was implemented, in order to generate a water-soluble, molecular/drug carrier with the capacity to undergo ...
Chrysie Aggelidou +4 more
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Treating a patient with ADP porphyria through suppression of both hepatic and erythroid ALA production [PDF]
Orphanet Journal of Rare Diseasesδ-Aminolevulinic acid dehydratase deficient porphyria (ADP) is an exceedingly rare form of acute porphyria, with only fifteen published cases worldwide.
Niels C. Veldhoen +4 more
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Assessment of Lead Exposure and Urinary-δ-aminolevulinic Acid Levels in Male Lead Acid Battery Workers in Tamil Nadu, India [PDF]
Journal of Health and Pollution, 2018 Background. Exposure to lead (Pb) affects multiple health outcomes and physiological systems. In adults, even small increases in blood Pb levels have been associated with decreased glomerular filtration rate, increased risk of hypertension and increased ...
Ravibabu Kalahasthi, Tapu Barman
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