Results 91 to 100 of about 1,001,244 (346)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Modelling the Full-Length Inactive PKC-δ Structure to Explore Regulatory Accessibility and Selective Targeting Opportunities [PDF]

Background/Objectives: Protein kinase C-δ (PKC-δ) is a pivotal regulator of cellular signalling, and its dysregulation contributes to oncogenesis. While certain isolated PKC-δ domains have been crystallised, the full-length architecture and interdomain ...
Dekker, Lodewijk V., Rasha Khader, Khader, Rasha, Lodewijk V. Dekker   +3 more
core   +2 more sources

The Δ/Δ/Δ/Δ mutant is avirulent in a mouse model of systemic candidiasis. [PDF]

, 2015
(A) 2.5 x 105C albicans cells were injected via the tail vein into 8-week old female Balb/c mice. Fourteen mice were injected with the wild type control strain LLF100, and 8 mice each were injected with either the Δ/Δ/Δ/Δ strain LLF060 or the ...
Sahil Sharma (790739), Shamoon Naseem (460666), Lifang Li (790738), James B. Konopka (460667)   +3 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases

Journal of Advanced Pharmaceutical Technology & Research, 2011
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ.
S. Tyagi, Paras Gupta, Arminder Singh Saini, Chaitnya Kaushal, Saurabh Sharma   +4 more
semanticscholar   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Measurements of the time-jitter of coherent terahertz synchrotron radiation with a superconducting detector [PDF]

, 2012
We have applied an ultrafast superconducting YBa2Cu3O7-δ (YBCO) detector to study the time jitter of the propagating electron bunches in a synchrotron. The jitter was determined from the coherent terahertz (THz) synchrotron radiation (CSR)
Hoehl, Arne, Pohl, Andreas, Ulm, Gerhard, Müller, Ralph, Feikes, Jörg, Hofherr, Matthias, Semenov, Alexej, Wüstefeld, Godehard, Hübers, Heinz-Wilhelm, Scheuring, Alexander, Probst, Petra, Ilin, Konstantin, Ries, Markus, Wünsch, Stefan   +13 more
core  

Plato's concept of ἀνάμνησις in the Phaidon

Revista Filosófica de Coimbra, 2021
Dieser Aufsatz betrachtet einige zentrale Aspekte der Charakterisierung der ἀνάμνησις im Phaedo 72e‘ 77a. Er analysiert die innerlich hervorrufende Natur der ἀνάμνησις und die diese Hervorrufung beeinträchtigenden Faktoren von λήθη. Der Phaedo zeigt, 1.
openaire   +1 more source

Observation of the ψð3686ß decays into Σ+ Σ - ω and Σ+ Σ - φ

, 2023
Based on (2712.4 +/- 14.3) x 106 events recorded at the psi(3686) nominal mass collected with the BESIII detector operating at the BEPCII collider, the psi(3686) -> E +/- E over bar -omega and E +/- E over bar -phi decays are observed for the first time with statistical significances of 13.8 sigma and 7.6 sigma, respectively.
Ablikim, M., Adlarson, Patrik, Johansson, Tord, Kupsc, Andrzej, Schönning, Karin, Thoren, V., Wolke, Magnus, Zu, J.   +7 more
openaire   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source