Results 81 to 90 of about 741,455 (295)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

open access: yesFEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao   +23 more
wiley   +1 more source

Plato's concept of ἀνάμνησις in the Phaidon

open access: yesRevista Filosófica de Coimbra, 2021
Dieser Aufsatz betrachtet einige zentrale Aspekte der Charakterisierung der ἀνάμνησις im Phaedo 72e‘ 77a. Er analysiert die innerlich hervorrufende Natur der ἀνάμνησις und die diese Hervorrufung beeinträchtigenden Faktoren von λήθη. Der Phaedo zeigt, 1.
openaire   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Effect of tsa2Δ deletion on the lethality of tsa1Δ rad51Δ trr1Δ.

open access: yes, 2014
Tetrad analysis of meiotic products of diploid strain tsa1Δ/TSA1 tsa2Δ/TSA2 rad51Δ/RAD51 trr1Δ/TRR1. These four loci are unlinked. 220 tetrads were dissected. 55 segregants of each genotype were expected.Effect of tsa2Δ deletion on the lethality of tsa1Δ
Roland Chanet (374699)   +11 more
core   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng   +4 more
wiley   +1 more source

Hemoglobin-δ-gluconolactone assay.

open access: yes, 2013
Results are mean ±SD and were compared with untreated blood (A = control blood; B = blood+δ-glu; C = blood+δ-glu+10 mM AG; D = blood+δ-glu+10 µM MF; E = blood+δ-glu+100 µM MF; F = blood+δ-glu+500 µM MF; G = blood+ δ-glu+1 mM MF; H = blood+ δ-glu+1 mM PM;
Uzma Shahab (285629)   +7 more
core   +1 more source

Pancuronium sensitivity of nAChR chimeras, δ/ε/δ and ε/δ/ε.

open access: yes, 2023
(A1), (B1), Pancuronium dependent inhibition of nAChRs. Data for the δ- and the ε-types are identical to those shown in Fig 1C. Data points are shown as mean ± sem. (A2), (B2), IC50s of chimeric subunits.
Souhei Sakata (17138188)   +1 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket   +14 more
wiley   +1 more source

Observation of the ψð3686ß decays into Σ+ Σ - ω and Σ+ Σ - φ

open access: yes, 2023
Based on (2712.4 +/- 14.3) x 106 events recorded at the psi(3686) nominal mass collected with the BESIII detector operating at the BEPCII collider, the psi(3686) -> E +/- E over bar -omega and E +/- E over bar -phi decays are observed for the first time with statistical significances of 13.8 sigma and 7.6 sigma, respectively.
Ablikim, M.   +7 more
openaire   +1 more source

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