Results 81 to 90 of about 2,357,602 (292)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The wind of rotating B supergiants, I : domains of slow and fast solution regimes [PDF]

, 2016
In the scenario of rotating radiation-driven wind theory for massive stars, three types of stationary hydrodynamic solutions are currently known: the classical ( fast) m-CAK solution, the Ω-slow solution that arises for fast rotators, and the so-called δ-
Araya, I., Cidale, Lydia Sonia, Curé, M., Venero, Roberto Oscar José   +3 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Διάχυτη Ενδοαγγειακή Πήξη: Παθοφυσιολογία, Διάγνωση, Αντιμετώπιση και η σχέση της με την κύηση και τον καρκίνο [PDF]

Epistīmonika Chronika, 2018
Η διάχυτη ενδαγγειακή πήξη (ΔΕΠ) χαρακτηρίζεται από συστηματική ενεργοποίηση του μηχανισμού της πήξης με αποτέλεσμα την παραγωγή ινώδους και την δημιουργία θρόμβων σε διάφορα όργανα, με τελική κατάληξη την πολυοργανική ανεπάρκεια.
Α. Περδίου, Δ. Συμεωνίδης, Κ. Σταθερού, Α. Κουσουλάκου   +3 more
doaj  

Electrochemical characteristics of the La0.9Sr0.1Sс0.4Mn0.6O3 – δ cathode contacting the La0.9Sr0.1SсO3 – δ proton-conducting electrolyte [PDF]

Электрохимическая энергетика
In this work, the material La0.9Sr0.1Sс0.4Mn0.6O3 – δ was synthesized using the citrate-nitrate method. The electrochemical characteristics of the material were studied using impedance spectroscopy on symmetric cells and compared with the ...
Bervitskaya, Olga S., Ichetovkina, Victoria A., Bobro, Mark S., Stroeva, Anna Y., Kuzmin, Anton Valerievich   +4 more
doaj   +1 more source

Almost Bi-Γ-Ideals and Fuzzy Almost Bi-Γ-Ideals of Γ-Semigroups

European Journal of Pure and Applied Mathematics, 2020
In this paper, we introduce the notions of almost bi-Γ-ideals and fuzzy almost bi-Γ-ideals of Γ-semigroups and give properties of them. Moreover, we investigate relationship between almost bi-Γ-ideals and fuzzy almost bi-Γ-ideals.
Anusorn Simuen, Saleem Abdullah, Winita Yonthanthum, Ronnason Chinram   +3 more
openaire   +2 more sources

Diversified Top-k Graph Pattern Matching [PDF]

, 2013
Graph pattern matching has been widely used in e.g., social data analysis. A number of matching algorithms have been developed that, given a graph pattern Q and a graph G , compute the set
Fan, Wenfei, Wang, Xin, Wu, Yinghui
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Συσχέτιση ισχαιμικού εγκεφαλικού επεισοδίου με δείκτη μάζας σώματος, κολπική μαρμαρυγή, δυσλιπιδαιμία, πορεία νοσηλείας κι έκβαση νόσου [PDF]

Epistīmonika Chronika, 2017
Εισαγωγή: Αρκετοί παράγοντες κινδύνου έχουν συσχετισθεί με την εμφάνιση αγγειακού εγκεφαλικού επεισοδίου ισχαιμικού τύπου (ΑΕΕ), ορισμένων εκ των οποίων ο κίνδυνος μπορεί να μειωθεί αρκετά με την κατάλληλη θεραπευτική αγωγή και συμμόρφωση του ατόμου. Η
Δ. Συμεωνίδης, Α. Καλέση, Γ. Χριστόπουλος, Σ. Αντωνόπουλος   +3 more
doaj  

On approximation f by (α,β,γ)-Baskakov Operators

Journal of Al-Qadisiyah for Computer Science and Mathematics, 2017
  In the present paper, we study some application properties of the approximation for the sequences  and   . These sequences depend on the arbitrary (but fixed) parameters  and . Here, we study the effect of these parameters on tends speed of the two families of operators  and  and the CPU times which are occurring on the approximation by a choosing ...
openaire   +2 more sources