Results 41 to 50 of about 741,455 (295)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Two-point normalization for reducing inter-laboratory discrepancies in δ 17O, δ 18O, and Δ′17O of reference silicates

open access: yesJournal of Analytical Science and Technology, 2020
The δ 17O and δ 18O values of a number of terrestrial minerals and rocks have been determined using laser fluorination method worldwide. For the comprehensive and congruous interpretation of oxygen isotope data, the δ-values should be normalized by the ...
Nak Kyu Kim   +2 more
doaj   +1 more source

Ψυχομετρική διερεύνηση μιας ορθογραφικής δοκιμασίας για μαθητές του δημοτικού σχολείου

open access: yesΨυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής Εταιρείας, 2020
Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ ...
Γεώργιος Δ. Σιδερίδης   +3 more
doaj   +1 more source

On Characterization of δ-Topological Vector Space

open access: yesRatio Mathematica, 2021
The main objective of this paper is to present the study of δ-topological vector space, δ-topological vector space are defined by using δ-open sets and δ-continuous mapping which was introduced by J.H.H. Bayati[3] in 2019. In this paper, along with basic
Shallu Sharma   +2 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Multi-isotope (δ 2H, δ 13C, δ 15N) feather profiles and morphometrics inform patterns of migratory connectivity in three species of North American swallows

open access: yesMovement Ecology, 2023
Aerial insectivorous birds have suffered steep population declines in North America over the last 60 years. A lack of information on migratory connectivity between breeding and non-breeding grounds for these species limits our ability to interpret ...
Keith A. Hobson, Kevin J. Kardynal
doaj   +1 more source

Development of lanthanum nickelate as a cathode for use in intermediate temperature solid oxide fuel cells [PDF]

open access: yes, 2011
The performance of lanthanum nickelate, La2NiO4+δ (LNO), as a cathode in IT-SOFCs with the electrolyte cerium gadolinium oxide, Ce0.9Gd0.1O2−δ (CGO), has been investigated by AC impedance spectroscopy of symmetrical cells.
Ansart, Florence   +11 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

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