Results 41 to 50 of about 725,304 (294)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Two-point normalization for reducing inter-laboratory discrepancies in δ 17O, δ 18O, and Δ′17O of reference silicates

Journal of Analytical Science and Technology, 2020
The δ 17O and δ 18O values of a number of terrestrial minerals and rocks have been determined using laser fluorination method worldwide. For the comprehensive and congruous interpretation of oxygen isotope data, the δ-values should be normalized by the ...
Nak Kyu Kim, Changkun Park, Minoru Kusakabe   +2 more
doaj   +1 more source

Ψυχομετρική διερεύνηση μιας ορθογραφικής δοκιμασίας για μαθητές του δημοτικού σχολείου

Ψυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής Εταιρείας, 2020
Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ ...
Γεώργιος Δ. Σιδερίδης, Αγγελική Μουζάκη, Αθανάσιος Πρωτόπαπας, Παναγιώτης Σίμος   +3 more
doaj   +1 more source

On Characterization of δ-Topological Vector Space

Ratio Mathematica, 2021
The main objective of this paper is to present the study of δ-topological vector space, δ-topological vector space are defined by using δ-open sets and δ-continuous mapping which was introduced by J.H.H. Bayati[3] in 2019. In this paper, along with basic
Shallu Sharma, Tsering Landol, Sahil Billawria   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Development of lanthanum nickelate as a cathode for use in intermediate temperature solid oxide fuel cells [PDF]

, 2011
The performance of lanthanum nickelate, La2NiO4+δ (LNO), as a cathode in IT-SOFCs with the electrolyte cerium gadolinium oxide, Ce0.9Gd0.1O2−δ (CGO), has been investigated by AC impedance spectroscopy of symmetrical cells.
Ansart, Florence, Skinner, S. J., Rieu, Mathilde, Lenormand, Pascal, Sayers, R., Kilner, J. A.   +5 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Multi-isotope (δ 2H, δ 13C, δ 15N) feather profiles and morphometrics inform patterns of migratory connectivity in three species of North American swallows

Movement Ecology, 2023
Aerial insectivorous birds have suffered steep population declines in North America over the last 60 years. A lack of information on migratory connectivity between breeding and non-breeding grounds for these species limits our ability to interpret ...
Keith A. Hobson, Kevin J. Kardynal
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source