Results 51 to 60 of about 725,304 (294)

Role of 18F-FDG PET/CT Metabolic Parameters in Treatment Response Evaluation and Prognostic Assessment of Hodgkin Lymphoma: A Retrospective Analysis

Turkish Journal of Hematology
Objective: This study aimed to evaluate the predictive value of volumetric metabolic parameters and their longitudinal changes from 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for progression-free survival (PFS) and ...
Hatice Uysal, Aziz Gültekin, Nil Güler, Nilay Şen Türk, Fikri Selçuk Şimşek, Tarık Şengöz, Doğangün Yüksel   +6 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Secretase promotes AD progression: simultaneously cleave Notch and APP

Frontiers in Aging Neuroscience
Alzheimer’s disease (AD) involves complex pathological mechanisms. Secretases include membrane protein extracellular structural domain proteases and intramembrane proteases that cleave the topology to type I or type II.
Ke-Fan Yang, Jing-Yi Zhang, Mei Feng, Kuo Yao, Yue-Yang Liu, Ming-Sheng Zhou, Hui Jia, Hui Jia   +7 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Το νέο Διεθνές Σύστημα Σταδιοποίησης ΤΝΜ του καρκίνου του πνεύμονος (8η έκδοση) [PDF]

Epistīmonika Chronika, 2018
Η Επιτροπή Σταδιοποίησης της Διεθνούς Ένωσης για τη μελέτη του Καρκίνου του Πνεύμονος δημιούργησε μια διεθνή βάση δεδομένων για τον καρκίνο του πνεύμονος, η οποία αποδείχθηκε χρήσιμη για την επίλυση πολλών θεμάτων σταδιοποίησης της νόσου , η οποία όπως
Ν. Μπαλταγιάννης, Δ. Αναγνωστόπουλος   +1 more
doaj  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The concept of the Sun as ἡγεμονικόν in the Stoa and in Manilius’Astronomica

Revista Archai, 2017
Hegemonikon in Stoic vocabulary is the technical term for the chief part or command-centre’of the soul. As we know, the Stoics considered the cosmos a living organism, and they theorised both about the human soul’s Hegemonikon and about its counterpart in the World-soul.
openaire   +3 more sources

On (μ1, μ2, μ3)-Weakly Generalized Closed Sets

European Journal of Pure and Applied Mathematics, 2020
This paper defines a new generalization of closed sets in a tri-generalized topological space called (μ1, μ2, μ3)-weakly generalized closed set (or briefly (μ1,μ2, μ3)-wg closed set) which is defined as follows: A subset A of X is (μ1, μ2, μ3)-weakly generalized closed set if clμ1(intμ2(A)) ⊆U whenever A ⊆ U and U is μ3-open in X.
Breix Michael Agua, Rolando N. Paluga
openaire   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source