Results 51 to 60 of about 741,455 (295)
Turkish Journal of HematologyObjective: This study aimed to evaluate the predictive value of volumetric metabolic parameters and their longitudinal changes from 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for progression-free survival (PFS) and ...
Hatice Uysal +6 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Secretase promotes AD progression: simultaneously cleave Notch and APP
Frontiers in Aging NeuroscienceAlzheimer’s disease (AD) involves complex pathological mechanisms. Secretases include membrane protein extracellular structural domain proteases and intramembrane proteases that cleave the topology to type I or type II.
Ke-Fan Yang +7 more
doaj +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Το νέο Διεθνές Σύστημα Σταδιοποίησης ΤΝΜ του καρκίνου του πνεύμονος (8η έκδοση) [PDF]
Epistīmonika Chronika, 2018 Η Επιτροπή Σταδιοποίησης της Διεθνούς Ένωσης για τη μελέτη του Καρκίνου του Πνεύμονος δημιούργησε μια διεθνή βάση δεδομένων για τον καρκίνο του πνεύμονος, η οποία αποδείχθηκε χρήσιμη για την επίλυση πολλών θεμάτων σταδιοποίησης της νόσου , η οποία όπως
Ν. Μπαλταγιάννης +1 more
doaj
Automatically derive the parameters δ and K according to the curve of the Δ(M,δ) and Δ(M,δ).
, 2015 First, for each δ in (A), (B) and (C), chose the M1 with the highest Δ (denoted as Δ1), then selected the(δ*,M*) and corresponding K with the highest stability measure α = Mb-Ma among all δ.
Lei Guo (36221) +8 more
core +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
ROS induction and survival of deletion mutants cta1Δ/Δ, grx2Δ/Δ and trx1Δ/Δ.
, 2012 (A) a. Upon neutrophil confrontation with strain grx2Δ/Δ, ROS accumulated. Deletion mutant lacking the catalase coding gene, cta1Δ/Δ, had only a slight and not significant increase in ROS accumulation, when compared to the wild type strain (CAI4 + CIp10).
Pedro Miramón (108557) +6 more
core +1 more source
Gene expression assays of efg1Δ/Δ and TDH3-TF efg1Δ/Δ strains by Nanostring.
, 2023 Nanostring analysis was conducted for SC5314, P87, and P75010 clinical isolate WT, efg1Δ/Δ, efg1Δ/Δ TDH3-BRG1, efg1Δ/Δ TDH3-UME6, efg1Δ/Δ TDH3-WOR3, efg1Δ/Δ TDH3-RFX2, efg1Δ/Δ TDH3-LYS143, efg1Δ/Δ TDH3-TYE7, and efg1Δ/Δ TDH3-orf19.6888. (XLSX)
Max V. Cravener (14504895) +6 more
core +1 more source