Results 151 to 160 of about 5,905 (229)

CP prediction from residual Z2s and Z‾2s symmetries with the latest data

Physics Letters B
The JUNO first data and the recent neutrino global fit results are implemented in the sum rule from the residual Z2s and Z‾2s symmetries to make prediction of the leptonic Dirac CP phase δD.
Shao-Feng Ge, Chui-Fan Kong, João Paulo Pinheiro   +2 more
doaj   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

The hydrogen isotopic composition of water vapor entering the stratosphere inferred from high‐precision measurements of δD‐CH4 and δD‐H2

, 2004
The hydrogen isotopic composition of water vapor entering the stratosphere provides an important constraint on the mechanisms for dehydration of air ascending through the tropical tropopause layer.
D. G. Johnson, E. Atlas, Tyler, S. C, Schauffler, S, S. C. Tyler, Johnson, D. G, Rice, A. L, M. C. McCarthy, McCarthy, M. C, T. Rahn, Atlas, E, K. A. Boering, Boering, K. A, Rahn, T, S. Schauffler, A. L. Rice, J. M. Eiler, Eiler, J. M   +17 more
core   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Leaf water deuterium enrichment shapes leaf wax n-alkane δD values of angiosperm plants II: observational evidence and global implications

, 2013
Leaf wax n-alkanes are long-chain hydrocarbons that can persist in sedimentary records over geological timescales. Since their hydrogen isotopic composition (expressed as a δD value) can be correlated to the δD values of precipitation, leaf wax n-alkane ...
Cernusak, Lucas A., Schefuß, Enno, Arndt, Stefan K., West, Jason B., Schefuβ, Enno, Kahmen, Ansgar, Hoffmann, Bernd, Sachse, Dirk   +7 more
core   +1 more source

Unlocking the Alkynyl Bromide Radical Anion With Alternating Current for Inverse Sonogashira C─H Coupling

Advanced Science, EarlyView.
An alternating current (AC)‐promoted, Pd‐catalyzed ortho‐aryl C─H alkynylation of 2,3‐diaryl acrylaldehydes is described. This synthetic scheme accommodates a broad substrate scope, delivering alkynylated stilbene derivatives with excellent arene site selectivity.
Junya Wang, Xiaozhou Wang, Pui Ying Choy, Chi‐Wai Cheung, Li‐Wen Xu, Hung Kay Lee, Gui‐Juan Cheng, Fuk Yee Kwong   +7 more
wiley   +1 more source

The hydrogen isotopic composition of water vapor entering the stratosphere inferred from high-precision measurements of δD-CH_4 and δD-H_2 [PDF]

, 2004
The hydrogen isotopic composition of water vapor entering the stratosphere provides an important constraint on the mechanisms for dehydration of air ascending through the tropical tropopause layer.
Tyler, S. C., Atlas, E., Boering, K. A., Eiler, J. M., Rahn, T., Schauffler, S., McCarthy, M. C., Johnson, D. G., Rice, A. L.   +8 more
core  

Physics‐Aware Machine‐Learning‐Driven Inverse Design of Broadband Ultra‐Open Acoustic Metamaterials

Advanced Science, EarlyView.
A physics‐aware machine‐learning framework enables inverse design of ultra‐open acoustic silencers by decoupling spectral and radial design spaces. The approach rapidly identifies broadband, compact, and highly ventilated architectures, while revealing hidden linear design rules that link geometry, impedance matching, and acoustic performance.
Zhiwei Yang, Mengyu Li, Xiaohang Xie, Ao Chen, Thomas G. Bifano, Xin Zhang   +5 more
wiley   +1 more source

Voltage‐Driven Non‐Volatile Interconversion Between Giant Single‐Domain and Multidomain Magnetic States in a Multiferroic Heterostructure

Advanced Science, EarlyView.
Non‐volatile voltage control of magnetic configurations is achieved in a strain‐coupled multiferroic heterostructure. Voltage pulses reversibly interconvert giant single‐domain and multidomain magnetic states, which remain stable at zero applied voltage. ABSTRACT Voltage control of magnetic states in multiferroic heterostructures represents a promising
M. Ghidini, S. Valencia, A. Lesaine, R. Mansell, V. Farenkov, X. Moya, N. A. Stelmashenko, F. Maccherozzi, C. W. H. Barnes, F. Kronast, S. S. Dhesi, N. D. Mathur   +11 more
wiley   +1 more source