Results 51 to 60 of about 1,820,241 (196)

Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors [version 1; referees: 2 approved]

Wellcome Open Research, 2018
Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state.
Vanessa Pereira, Queensta Millet, Jose Aramburu, Cristina Lopez-Rodriguez, Claire Gaveriaux-Ruff, John N. Wood   +5 more
doaj   +1 more source

Toll‐Like Receptor 4 Signaling in Natural N‐Acylethanolamines and Derivative NAE‐Like Compounds: Mechanisms and Implications for Neuroimmune and Inflammatory Processes in a Systematic Search Approach

Phytotherapy Research, EarlyView.
ABSTRACT N‐acylethanolamines (NAEs) are endogenous fatty acid amides structurally related to the endocannabinoid anandamide and function as bioactive lipid mediators with broad regulatory roles in inflammation and neuroinflammation. Among pattern‐recognition receptors, Toll‐like receptor 4 (TLR4) occupies a central position in innate immune ...
Damiana Scuteri, Francesca Guida, Giacinto Bagetta, Sabatino Maione, Maria Tiziana Corasaniti, Morena Zusso   +5 more
wiley   +1 more source

N -Alkyl-octahydroisoquinolin-1-one-8-carboxamides: Selective and Nonbasic κ-Opioid Receptor Ligands [PDF]

, 2010
Herein, we report that N-alkyl-octahydroisoquinolin-1-one-8-carboxamides are a novel class of readily synthesized, selective κ-opioid receptor (KOR) ligands. A striking feature of this class of compounds is the absence of any basic nitrogen atoms.
Tran, Thuy B., Ghosh, Partha, Roth, Bryan L., Aubé, Jeffrey, Frankowski, Kevin J., Setola, Vincent   +5 more
core   +1 more source

µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice

Translational Psychiatry
Mood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid peptides, are important for emotion regulation.
Khalin E. Nisbett, Leandro F. Vendruscolo, George F. Koob   +2 more
doaj   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source

Effects of κ-opioid receptor activation on myocardium

, 2001
κ-Opioid receptor stimulation of the heart transiently increases twitch amplitude and decreases Ca2+-dependent actomyosin Mg2+-ATPase activity through an undetermined mechanism.
J. W. Lester, P. A. Hofmann, W. G. Pyle
core   +1 more source

Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implicationsCapsule Summary

JAAD International, 2022
Introduction: Treating chronic pruritus is challenging for dermatologists due to the lack of therapeutic options. We review the effects of κ-opioid receptor (KOR) and μ-opioid receptor (MOR) in the modulation of itch, summarize evidence supporting the ...
Sarina Elmariah, MD, PhD, Sarah Chisolm, MD, Thomas Sciascia, MD, Shawn G. Kwatra, MD   +3 more
doaj   +1 more source

The psychometric properties of validated tools to assess cannabis use disorder: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Aims To systematically review the evidence on the psychometric performance and accuracy of screening or diagnostic tools for cannabis use disorder. Method Systematic review and meta‐analysis which included studies conducted in clinical settings, schools, universities, community settings and population‐based surveys in multiple countries and ...
Janni Leung, Daniel Stjepanovic, Stephanie Fong, Danielle Dawson, Giang Vu, Tesfa Yimer, Caitlin McClure‐Thomas, Wayne Denis Hall, Gary Chung Kai Chan   +8 more
wiley   +1 more source

The bidirectional predictive association between methamphetamine use and depression

Addiction, EarlyView.
Abstract Background and aims Co‐occurrence of methamphetamine dependence and depression is high, though the direction of this temporal relationship is unclear. We investigated the direction of the temporal relationship between methamphetamine use and depression.
Lucy T. Tran, Philip J. Clare, Louisa Degenhardt, Dan I. Lubman, Michael Berk, Gregory Carter, Shalini Arunogiri, Alyna Turner, Olivia M. Dean, Peter Kelly, Rebecca McKetin   +10 more
wiley   +1 more source

Clinical features of mental imagery in substance use disorders: A mixed‐methods analysis

Addiction, EarlyView.
Abstract Aims To characterise the frequency, features and content of craving‐related mental imagery among people seeking treatment for substance use disorders (SUDs); examine within‐session change in self‐reported craving following imagery elicitation; and explore perceived links with autobiographical memory, behavioural, cognitive and emotional ...
Gemma Scott, Tim Meynen, Francesca Small, Luke Mitcheson, Elizabeth Appiah‐Kusi, William Barber, Colette Hirsch, John Marsden   +7 more
wiley   +1 more source