Results 31 to 40 of about 1,820,241 (196)
Characterization of BU09059:A novel potent selective κ-receptor antagonist [PDF]
, 2014 Kappa-opioid receptor (κ) antagonists are potential therapeutic agents for a range of psychiatric disorders. The feasibility of developing κ-antagonists has been limited by the pharmacodynamic properties of prototypic κ-selective antagonists, that is ...
Ostovar, Mehrnoosh +7 more
core +1 more source
Cellular Physiology and Biochemistry, 2017 Background/Aims: In a previous study, we showed that κ-opioid receptor stimulation with the selective agonist U50,488H ameliorated hypoxic pulmonary hypertension (HPH).
Yaguang Zhou +13 more
doaj +1 more source
Quantitative Receptor Autoradiography in Opioid Peptide and Receptor Knockout Mice. [PDF]
, 2020 1. The ORL1 receptor and its endogenous peptide nociceptin or orphanin FQ (N/OFQ) are novel members of the opioid receptor family. Despite the homology displayed between the opioid and ORL1 systems the ORL1 receptor and nociceptin display anti-opioid ...
Clarke, Sian.
core +1 more source
Bidirectional Regulation of Opioid and Chemokine Function
Frontiers in Immunology, 2020 The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
doaj +1 more source
coupling to the rat κ‐opioid receptor
, 1995 We have expressed the cloned rat κ-opioid receptor in human embryonic kidney 293 cells and studied the ability of κ-selective ligands to inhibit adenylyl cyclase. In transfected 293 cells, activation of the κ-opioid receptor by U50,488 and the dynorphins
Yung H. Wong +7 more
core +1 more source
Hypoxia Induces Internalization of κ-Opioid Receptor
, 2017 Background It has been demonstrated that κ-opioid receptor agonists can reduce hypoxia–ischemia brain injury in animal models. However, it is unclear how the κ-opioid receptor responds to hypoxia–ischemia.
Chunhua Chen +5 more
core +1 more source
In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor [PDF]
, 2013 Accumulating evidence supports a role for κ−opioid receptor antagonists in the treatment of mood disorders. Standard κ-antagonists have an unusual pharmacodynamic action, with a single injection blocking receptor signaling for several weeks.
Clark, M. +4 more
core +1 more source
Central nicotine induces browning through hypothalamic κ opioid receptor
Nature Communications, 2019 Nicotine reduces food intake and increases energy expenditure in brown adipose tissue. Here the authors show that nicotine also induces white adipose tissue browning via central kappa opioid receptor action.
Patricia Seoane-Collazo +21 more
doaj +1 more source
κ-Opioid Receptor Agonists Modulate Visceral Nociception at a Novel, Peripheral Site of Action
, 2000 κ-opioid receptor agonists (κ-ORAs) have been shown to modulate visceral nociception through an interaction with a peripheral, possibly novel, κ-opioid-like receptor.
Xin Su +3 more
core +1 more source
Molecules, 2022 Opioid receptors are members of the group of G protein-couple receptors, which have been proven to be effective targets for treating severe pain. The interactions between the opioid receptors and corresponding ligands and the receptor’s activation by ...
Peng Xie +8 more
doaj +1 more source