Results 11 to 20 of about 1,820,241 (196)
Journal of Pharmacological Sciences, 2003 : κ-Opioid receptor agonists decrease the levels of extracellular dopamine in vivo and in vitro. However, the mechanism(s) underlying these actions are unclear.
Nuannoi Chudapongse +3 more
doaj +2 more sources
Journal of Pharmacological Sciences, 2005 The supraspinal and spinal antinociceptive effects of several κ-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.
Masahiro Ohsawa, Junzo Kamei
doaj +2 more sources
Ligand and G-protein selectivity in the κ-opioid receptor. [PDF]
Nature, 2023 The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective ...
Han J +13 more
europepmc +2 more sources
Butorphanol: Effects of a Prototypical Agonist-Antagonist Analgesic on κ-Opioid Receptors
Journal of Pharmacological Sciences, 2005 The opioid analgesic, butorphanol (17-cyclobutylmethyl-3,14-dihydroxymorphinan) tartrate is a prototypical agonist-antagonist opioid analgesic agent whose potential for abuse has been the cause of litigation in the United States.
Stephen Commiskey +3 more
doaj +1 more source
Κ-opioid receptor stimulation improves endothelial function in hypoxic pulmonary hypertension. [PDF]
PLoS ONE, 2013 The present study was designed to investigate the effect of κ-opioid receptor stimulation with U50,488H on endothelial function and underlying mechanism in rats with hypoxic pulmonary hypertension (HPH).
Qi Wu +11 more
doaj +1 more source
Molecules, 2021 Opioid analgesics are clinically used to relieve severe pain in acute postoperative and cancer pain, and also in the long term in chronic pain. The analgesic action is mediated by μ-, δ-, and κ-receptors, but currently, with few exceptions for k-agonists,
Sandra Piras +12 more
doaj +1 more source
IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics
Pharmacological Research, 2023 Though efficacious in managing chronic, severe pain, opioid analgesics are accompanied by significant adverse effects including constipation, tolerance, dependence, and respiratory depression.
Kyle J. Rehrauer +1 more
doaj +1 more source
Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands [PDF]
, 2013 Salvinorin A, the active ingredient of the hallucinogenic plant Salvia divinorum is the most potent known naturally occurring hallucinogen and is a selective κ-opioid receptor agonist.
Polepally, Prabhakar R. +5 more
core +1 more source
Role of Endogenous Opioid System in Ischemic-Induced Late Preconditioning. [PDF]
PLoS ONE, 2015 Opioid receptors (OR) are involved in myocardial late preconditioning (LPC) induced by morphine and δ1-opioid receptor (δ1-OR) agonists. The role of OR in ischemic-induced LPC is unknown.
Jan Fraessdorf +6 more
doaj +1 more source
Journal of Pharmacological Sciences, 2006 .: Generalizations of NMDA-receptor antagonists to the discriminative stimulus effects of κ-opioid receptor agonists in rats were examined. Phencyclidine, MK-801, and ketamine, noncompetitive NMDA-receptor antagonists, generalized to the discriminative ...
Tomohisa Mori +6 more
doaj +1 more source