Nalfurafine Hydrochloride, a κ-Opioid Receptor Agonist, Induces Melanophagy via PKA Inhibition in B16F1 Cells [PDF]
Cells, 2022 Selective autophagy controls cellular homeostasis by degrading unnecessary or damaged cellular components. Melanosomes are specialized organelles that regulate the biogenesis, storage, and transport of melanin in melanocytes.
Ha Jung Lee +13 more
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κ-opioid receptor: from analgesic target to neuroimmune hub [PDF]
Frontiers in PharmacologyOriginally characterized as a classical mediator of analgesia, the κ-opioid receptor (KOR) has recently emerged as a pivotal regulator at the crossroads of the nervous and immune systems.
Qinsi Tan, Mengjin Zheng, Huaixin Xing
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Effects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors [PDF]
Scientific Reports, 2023 Opioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders.
Soichiro Ide +4 more
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Central δ/κ opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation [PDF]
The Journal of Reproduction and DevelopmentIn mammals, secretion of tonic (pulsatile) gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) is often suppressed during lactation. Suppression of GnRH/LH pulses in lactating dams is assumed to be caused by suckling stimuli and a chronic ...
Yoshihisa UENOYAMA +6 more
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Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development [PDF]
MoleculesThe opioid crisis in the United States is a significant public health issue, with a nearly threefold increase in opioid-related fatalities between 1999 and 2014. In response to this crisis, society has made numerous efforts to mitigate its impact. Recent
Zoe Li +11 more
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Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice. [PDF]
PLoS ONE, 2014 Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system
Zi-long Wang +10 more
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Molecules, 2021 Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid agonists
Yusuke Karasawa +12 more
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Frontiers in Medicine, 2022 BackgroundMyoclonic movement is a very common but undesirable phenomenon during the induction of general anesthesia using etomidate. Such movement may cause unnecessary problems.
Kang-Da Zhang +5 more
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Pain and Therapy, 2020 Buprenorphine is a Schedule III opioid analgesic with unique pharmacodynamic and pharmacokinetic properties that may be preferable to those of Schedule II full μ-opioid receptor agonists.
Jeffrey Gudin, Jeffrey Fudin
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Analyzing Interaction of μ-, δ- and κ-opioid Receptor Gene Variants on Alcohol or Drug Dependence Using a Pattern Discovery-based Method [PDF]
Journal of Addiction Research & Therapy, 2012 Background: Polymorphisms in the μ-, δ- and κ-opioid receptor genes (OPRM1, OPRD1 and OPRK1) have been reported to be associated with substance (alcohol or drug) dependence. The influence of an individual gene on a disease trait should be more evident when analyzed in the context of gene-gene interactions. Thus, we assessed the joint effect of variants
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