Results 61 to 70 of about 1,407,805 (180)

茵陈蒿汤主成分治疗代谢相关脂肪性肝病的配伍剂量优化及作用机制实验研究

浙江大学学报. 医学版
目的探讨茵陈蒿汤主效应组分栀子苷、绿原酸和大黄多糖改善代谢相关脂肪性肝病（MAFLD）的最佳剂量配比和作用机制。方法将C57BL/6小鼠随机分为正常对照组、模型对照组、均匀设计1~6组、茵陈蒿汤组。除正常对照组外，其余各组采用西方饮食饲料建立MAFLD模型，均匀设计1~6组和茵陈蒿汤组在造模8周后通过灌胃给予相应药物。12周后处死所有小鼠，称取小鼠的体重和肝脏质量，苏木精-伊红染色观察肝组织病理学变化，检测血浆丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）水平，检测血浆及肝脏总胆固醇（TC）、甘油三酯（
高 艳艳, 薛 茹云, 徐 芳莹, 陈 林, 邱 剑楠, 窦 晓兵   +5 more
doaj   +1 more source

A Dual‐Function Mitochondria‐Targeted Polyoxometalate Nanomicelle Boosts Pyroptosis‐Dependent Antitumor Immune Response in Triple‐Negative Breast Cancer

Rare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT The efficacy of immunotherapy in triple‐negative breast cancer (TNBC) is often limited, whereas the immunotherapeutic potential of pyroptosis is frequently undermined by a compensatory surge in mitophagy. To address this challenge, this study developed a reactive oxygen species (ROS)‐responsive and mitochondria‐targeted nanomicelle (POM@CTT ...
Qingqing Dou, Peixiao Jiang, Fang Zhang, Kun Yang, Zhichao Li, Mo Zhang, Jing Wang   +6 more
wiley   +1 more source

中药袋泡茶剂的现代定位与关键问题分析

, 2017
中药袋泡茶剂是中药传统剂型的传承与发扬,是传统中医药理论与现代生活的融合,符合简便快捷的中药制剂要求,契合消费者回归自然的养生理念.该文从中药袋泡茶剂的“中医药理论”“物质基础”和“制剂工艺”3个方面揭示其科学内涵,同时还对中药袋泡茶剂的历史沿革、制剂特色 ...
zhao, J, fu, C, Chen, J, GAO, F
core   +1 more source

B细胞内源性拟素化可调控小鼠免疫反应

浙江大学学报. 医学版
目的探究拟素化在B细胞介导免疫应答中的调控作用。方法利用Cre-LoxP系统构建B细胞特异性Ube2m基因敲除的CD19cre/+Ube2mfl/fl小鼠，以同窝出生的Ube2mfl/fl小鼠作为正常对照。分别采用非胸腺依赖性抗原4-羟基-3-硝基苯乙酰基（NP）-脂多糖（LPS）、2，4-二硝基苯基（DNP）-Ficoll和胸腺依赖性抗原NP-鸡丙种球蛋白（CGG）、DNP-匙孔血蓝蛋白（KLH）免疫接种小鼠，采用酶联免疫吸附试验检测血清中各类特异性抗体水平，并对NP-LPS和NP ...
金 鑫, 竺 露瑶, 章 力之, 陈 天杭, 周 明倩   +4 more
doaj   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, Volume 36, Issue 34, 27 April 2026.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

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Lughawiyah: Journal of Arabic Education and Linguistics, 2019
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openaire   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, Volume 18, Issue 4, Page 426-442, April 2026.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

Application of CDIO model in clinical practice training of Traditional Chinese Medicine nursing specialists (CDIO模式在省级中医护理专业化护士临床实践培训中的应用)

中西医结合护理
Objective To evaluate the application of CDIO model in clinical practice training of Traditional Chinese Medicine nursing specialists. Methods A total of 32 nurses who participated in the specialized training program of Traditional Chinese Medicine ...
CHENG Yanfei (程燕飞), WANG Bei (王蓓), LI Jianing (李佳凝), WANG Fengmei (王凤美), ZHANG Xixia (章细霞), CHEN Zhenghong (陈正红), ZHOU Jian (周健)   +6 more
doaj   +1 more source

Developing HMME‐Conjugated NIR‐II Activated Carbon Dots Nanospray for the Treatment of MRSA Biofilm Infections in Diabetic Wound via PTT/CDT/SDT

Rare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT Diabetic wound infections are a common complication of diabetes, which severely impact patients' quality of life. Effective treatment of diabetic wound infections remains one major challenge in the clinic, partially due to the formation of bacterial biofilm and antibiotic resistance.
Liang Zhou, Ning Wang, Zumeng Wang, Pingping Zhang, Yuqin Chu, Yingguang Liu, Wen Liu, Chengwu Zhang, Lili Yan   +8 more
wiley   +1 more source

Threats to and management of Natura 2000 protected areas relative to agricultural practices

Conservation Biology, Volume 40, Issue 2, April 2026.
Abstract The Natura 2000 (N2K) network combines biodiversity protection and socioeconomic targets. Human activities, such as agricultural practices, can affect biodiversity in N2K sites in diverse ways. Limiting activities with negative impacts while enforcing land management that supports biodiversity is crucial for effective conservation.
Giorgio Zavattoni, Elie Gaget, Tyler Hallman, Ineta Kačergytė, Tomas Pärt, Diego Pavón‐Jordán, Thomas Sattler, Jon E. Brommer   +7 more
wiley   +1 more source