Results 121 to 130 of about 7,842 (168)

[Metabolomic alterations in preterm infants with bronchopulmonary dysplasia]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Wu YY, Bu QQ, Wang X, Li T, Wu HY, Kang L, Wang YY, Liu DP, Guo J, Wang CJ, Kang WQ.   +10 more
europepmc   +1 more source

基于蛋白组学分析蓝光对豚鼠眼球正视化过程的影响

Zhongshan Daxue xuebao. Yixue kexue ban
目的探讨蓝光对豚鼠眼球正视化过程的影响和蓝光在正视化过程中的潜在机制，并评估其在近视防控中的潜在应用价值。方法将20只3周龄雄性豚鼠随机分到白光组和蓝光组，每2周测量屈光度和眼部生物学参数，直至第8周实验结束。并利用蛋白组学技术4D-数据非依赖型采集（4D-DIA）对蓝光组和白光组的豚鼠视网膜进行检测，探索蛋白组成、表达差异以及对应的生物学功能。结果2周后，白光组中豚鼠逐渐向正视状态发展，蓝光组出现远视漂移，组间屈光度存在显著差异（P<0.001）。自第4周起，蓝光组的眼轴长度显著小于白光组（P ...
肖珺心, 权卓娅, 肖虎, Thomas Cheun Lam, 朱敏怡, 王丹阳   +5 more
doaj  

[Applications and Advances of Metabolomics in Lung Cancer Research]. [PDF]

Zhongguo Fei Ai Za Zhi
Wang D, Huang Z, Li B, Wang Y, Wang Z, Zhang N, Wei Z, Liang N, Li S.   +8 more
europepmc   +1 more source

基于代谢组学探究七氟烷吸入麻醉中高血压患者的血清代谢变化

Zhongguo shiyan zhenduanxue
目的探讨七氟烷吸入全身麻醉对高血压患者术前术后血清代谢组学的影响，通过识别差异代谢物并进行KEGG通路富集分析，以揭示七氟烷吸入麻醉在围术期对患者可能产生的潜在效应。方法本研究共纳入了15例拟行全身麻醉下行全髋关节置换的受试者，分别于术前术后1 h采集外周静脉血，共制备30例血清样本。采用气相色谱-质谱代谢组学法检测血清代谢物，使用R语言包对检测数据进行主成分分析（PCA）、正交偏最小二乘判别分析(OPLS-DA)，设置阈值为P<0.05和VIP值> ...
沈吉喆, 黄立政, 韩方雷, 陈曦
doaj  

[Research progress of metabolomics in children with irritable bowel syndrome]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Chen XL, Jiang MZ.
europepmc   +1 more source

[Untargeted metabolomics reveals differential serum metabolites and metabolic pathways in patients with primary Sjögren syndrome and thrombocytopenia]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Xiang Z, Yang L, Yang J.
europepmc   +1 more source

[Analysis of ischemic stroke biomarkers based on non-targeted metabolomics]. [PDF]

Se Pu
Xu F, Liu TP, Guan YJ, Hao WC, Wen DS, Xie SL, Bie YN.   +6 more
europepmc   +1 more source

脂代谢紊乱破坏线粒体功能导致大鼠动脉粥样硬化形成

Zhongguo shiyan zhenduanxue
目的 通过大鼠高脂饮食模型了解脂代谢相关基因mRNA表达水平和线粒体功能在主动脉粥样硬化形成中的作用。方法 高脂饮食联合维生素D3建立大鼠动脉粥样硬化模型，检测血清中血脂指标以及脂质代谢基因和线粒体合成和分解基因mRNA表达水平。结果 模型组主动脉和颈动脉动脉粥样硬化形成明显，并且随着时间的延长病变加重。与对照组比较，模型组Lp(a)、TC、TG和LDL-C水平明显高于对照组(P0.05)。另外，模型组主动脉组织脂代谢相关基因SREBF2、LDL、HMGCR、FDFT1、HMGCS 1 ...
宋子凯, 李忠乐, 赵亚明, 叶琳
doaj  

[Effects of nicotine exposure on endogenous metabolites in mouse brain based on metabolomics and mass spectrometry imaging]. [PDF]

Se Pu
Guo LL, Zhang C, Huang YJ, Liu XY, Liu DS, Long T, Sun JH, Liu SF, Li ZH, Wang JZ, Mao J.   +10 more
europepmc   +1 more source

[Mechanisms of Wandai Decoction in Improving Vaginal Flora of Vulvovaginal Candidiasis of the Spleen Deficiency and Excessive Dampness Type: A Study Based on Metagenomics and Metabolomics]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Han Y, Shen S, Fu J, Ren Q.
europepmc   +1 more source