Results 31 to 40 of about 25,319 (217)

代谢组学在代谢性脑血管病中的应用研究 Application of Metabolomics in Cerebro-Metabolic Disease

open access: yesZhongguo cuzhong zazhi
脑血管病是全球范围内导致人类死亡和残疾的主要原因,其中很高比例与代谢紊乱相关。代谢性脑血管病是指由传统代谢危险因素和残余代谢危险因素导致的脑血管损害,以血管结构受损及功能障碍为主要病理生理学表现,干预代谢危险因素可有效改善预后的一种临床综合征。代谢组学是采用高通量组学技术对所有代谢物进行鉴定和定量的手段,是未来研究代谢性脑血管病的重要抓手。本文总结了代谢组学、脂质组学在代谢性心脑血管疾病方面的研究,旨在为代谢性脑血管病的代谢组学研究开展及其临床防治提供参考。 Abstract ...
钟文华1,薛婧2,许杰1,2 ( ZHONG Wenhua1, XUE Jing2, XU Jie1,2 )
doaj   +1 more source

A Preliminary Study On Activating AMPK By MED [PDF]

open access: yes, 2010
依赖于5’-AMP激活的蛋白激酶——AMPK在保持细胞微环境的能量稳态上扮演了至关重要的角色,能够被细胞内AMP的增多和ATP的减少所激活,作为代谢感受器调节细胞内ATP相关的代谢途径。AMPK除了调节糖代谢,脂代谢,蛋白质合成等很多能量相关的物质代谢途径外,还在细胞凋亡和血管生成途径中起到重要调节作用。如果能量代谢失衡,则会引起代谢综合症等多种疾病,严重影响现代人的生活,威胁人的健康。作为能量代谢过程中的关键酶,AMPK可以作为代谢综合症的治疗靶点。 AMPK不仅能够被细胞内AMP ...
杨梅
core  

Internal physiological drivers of leaf development in trees: Understanding the relationship between non‐structural carbohydrates and leaf phenology

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Plant phenology is crucial for understanding plant growth and climate feedback. It affects canopy structure, surface albedo, and carbon and water fluxes. While the influence of environmental factors on phenology is well‐documented, the role of plant intrinsic factors ...
Yunpeng Luo   +8 more
wiley   +1 more source

Abnormal lipid metabolism in pterygium [PDF]

open access: yes, 2015
研究背景:翼状胬肉作为一种常见的眼科疾病,其发病机理尚未明确,目前缺乏有效的药物治疗方法,手术切除是唯一有效的治疗方式。深入研究翼状胬肉的病理改变将有助于揭示翼状胬肉的病理生理过程,为发展新的治疗方法奠定基础。近年来,有研究发现翼状胬肉组织中存在异常脂类代谢,但是异常脂类代谢在翼状胬肉发生发展中的作用仍不清楚。 实验目的:检测翼状胬肉组织中的异常脂类代谢,探究脂类代谢异常在翼状胬肉发生发展过程中的作用。 实验方法:本实验收集35例翼状胬肉患者的病理组织和5例患者的正常结膜组织,用于冰冻包埋 ...
邹笃雷
core  

Parental care and bird embryonic metabolism: A comparison between uniparentally incubating Silver‐throated Tits and biparentally incubating Black‐throated Tits

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Studies have shown that organisms may adjust metabolic rates in response to thermal variability, highlighting metabolic plasticity as a key adaptive mechanism. Understanding the extent of metabolic plasticity of an organism is key to predicting its adaptation to climate
Qian Hu   +6 more
wiley   +1 more source

Research progress on the dynamic patterns of physical activity in elderly patients with diabetes mellitus (老年糖尿病患者体力活动动态模式的研究进展)

open access: yes中西医结合护理
With the acceleration of global aging, the prevalence of diabetes among the elderly has been rising year by year. Physical activity, as an essential component of comprehensive diabetes management, plays a positive role in improving the health status of ...
HU Yixiang (胡怡香)   +7 more
doaj   +1 more source

低pH对草鱼呼吸活动和耗氧代谢的影响 [PDF]

open access: yes, 1992
研究了低pH(6.0—3.6)对草鱼呼吸活动机能及耗氧代谢的影响.结果表明,在pH4.6—3.6条件下,草鱼呼吸和气体代谢活动受干扰的程度随酸度增大而急剧加重.其具体表现为:呼吸率加快,咳嗽反应增加,呼吸深度加大.耗氧率起始升高继而迅速下降,并在极端pH(3.6)下最终引起机体组织缺氧而致死.对于pH5.6,草鱼各类呼吸与代谢指标未受明显影响,基本属于正常.供试草鱼对低pH反应的灵敏程度依次为:咳嗽率>呼吸率>耗氧率> ...
余日清,贺锡勤
core  

Self‐Consumption Translation: Exploring Interlingual Translation Within Multilingual (mainland) China

open access: yesInternational Journal of Applied Linguistics, EarlyView.
ABSTRACT Interlingual translation, as defined by Roman Jakobson, refers to the transfer of meaning between languages. However, this concept has often been conflated with linguistic shifts between distinct cultures and nation‐states. To challenge this misconception, I propose the concept of self‐consumption translation (SCT), a subfield of interlingual ...
Bilin (Belen) Liu
wiley   +1 more source

Malignancy-associated metabolic profiling of human glioma cell lines using 1H NMR spectroscopy [PDF]

open access: yes, 2015
胶质瘤恶性转化的原因和机制不明,给临床诊疗带来极大困难。越来越多的研究表明肿瘤恶性转化与细胞代谢紊乱密切相关,但胶质瘤恶性转化相关的细胞代谢特点目前尚不清楚。因此,探寻不同恶性程度胶质瘤细胞的代谢轮廓,将有助于开发监测胶质瘤恶性进展的非入侵式生物标志物和靶向代谢通路的治疗策略。本研究收集5种不同病理级别瘤组织来源的人脑胶质瘤细胞系(CHG5/SHG44/U118/U87/U251),其中CHG5和SHG44为WHOII级来源;U118,U87和U251为WHOIV级来源。体外培养后,首先通过侵袭能力 ...
邵巍
core  

Optimization of mixed fermentation technology of Lactobacillus helveticus andLactobacillus rhamnosus based on high viable count [PDF]

open access: yes, 2016
以瑞士乳杆菌和鼠李糖乳杆菌混合发酵培养,利用两菌株细胞代谢的差异,以静置发酵24 h后得到的活菌数目为指标,通过单因素实验和正交实验,研究了瑞士乳杆菌和鼠李糖乳杆菌高活菌数混合发酵的最适发酵条件。结果表明,瑞士乳杆菌和鼠李糖乳杆菌高活菌数混合发酵的最优条件为:发酵温度37℃,初始pH=6.8,接种量6%,瑞士乳杆菌:鼠李糖乳杆菌=1∶2,瑞士乳杆菌优先接种3 h。最终得到乳酸菌总活菌数为7.2×10~9m L~(-1)。与在相同条件下单独发酵的瑞士乳杆菌和鼠李糖乳杆菌活菌数相比,分别提高了1∶8倍和10.
李敬龙   +3 more
core   +1 more source

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