Results 31 to 40 of about 42,433 (259)
[Progress in the metabolic and biotransformation of polycyclic aromatic hydrocarbons and their derivatives in humans]. [PDF]
Se Pu多环芳烃（polycyclic aromatic hydrocarbons，PAHs）广泛存在于各类生产及生活环境中，因毒性高对公众健康构成了严重威胁。PAHs及其衍生物可通过多种途径进入人体，在细胞色素P450酶的催化作用下，生成Ⅰ相代谢产物，并进一步在Ⅱ相代谢阶段与谷胱甘肽、葡萄糖醛酸等物质结合，生成水溶性结合产物。不同代谢阶段的产物在人体内的分布与表现形式可作为PAHs暴露的重要标志物。然而，由于不同结构特征的PAHs在代谢机制及其产物种类方面存在显著差异 ...
Qian JK +6 more
europepmc +2 more sources
Journal of Diabetes, Volume 15, Issue 8, Page 685-698, August 2023., 2023 Highlights Vascular complication is one of the most important causes of death in diabetes patients. Arterial stiffness plays a key role in the progress of diabetes vascular complication; therefore, the improvement of arterial stiffness could inhibit the process of atherosclerosis and reduce the burden of diabetes vascular complications This study first
Jincheng Wang +14 more
wiley +1 more source
[Integrative transcriptomics-metabolomics approach to identify metabolic pathways regulated by glutamine synthetase activity]. [PDF]
Se Pu谷氨酰胺合成酶(GS)是细胞中唯一可以从头合成谷氨酰胺的酶,在癌症代谢中扮演着重要角色。GS酶活缺陷突变往往导致严重的代谢疾病甚至是死亡。理解GS酶活降低对生理功能的影响可能为靶向治疗提供新的方向,同时对其内在机制的探索可以为治疗干预开辟新的途径。已报道的GS酶活缺陷突变包括R324C(第324位精氨酸突变为半胱氨酸)和R341C(第341位精氨酸突变为半胱氨酸)等,本研究新发现了GS的另一个酶活缺陷突变位点K241(第241位赖氨酸)。为了探究GS酶活缺陷突变带来的影响 ...
Ling T +5 more
europepmc +2 more sources
Journal of Diabetes, Volume 15, Issue 8, Page 699-708, August 2023., 2023 Highlights This study is the first to evaluate the efficacy of the closed‐loop system MiniMed 780G in children aged 6 to 17 years with type 1 diabetes previously receiving continuous subcutaneous insulin infusion and intermittent continuous glucose monitoring. This shows early results, with improvement in time in range and all hyperglycemia times, from
Alfonso Lendínez‐Jurado +7 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 8, Page 665-673, August 2023., 2023 Highlights Interventional techniques offer novel therapeutic approaches for metabolic disorders such as obesity and type 2 diabetes mellitus, with advantages such as less invasiveness, fewer potential complications, and lower costs. By embolizing specific arteries feeding ghrelin‐producing cells, bariatric arterial embolization not only promotes weight
Zhi Wang +9 more
wiley +1 more source
基于非靶向代谢组学的茄梨和红茄梨成熟期果皮代谢产物的差异分析
Se pu = Chinese journal of chromatography, 2021 为了探究西洋梨品种茄梨及其红色芽变红茄梨成熟期果皮代谢产物差异,采用超高效液相色谱-质谱联用技术,对茄梨和红茄梨成熟期果皮进行非靶向代谢组学研究。通过主成分分析和正交偏最小二乘判别分析,构建了多变量统计分析模型,结合模型和变量重要性投影与最大差异倍数值,基于精确质量数、二级碎片以及同位素分布,使用PMDB(Plant Metabolome Database)数据库进行定性,筛选并鉴定出茄梨和红茄梨果皮中显著性变化 ...
H. Mu +8 more
semanticscholar +1 more source
Journal of Diabetes, Volume 15, Issue 6, Page 519-531, June 2023., 2023 Highlights For distinguishing glucokinase maturity‐onset diabetes of the young (GCK‐MODY) from hepatocyte nuclear factor 1‐α MODY (HNF1A‐MODY), total triglycerides may help during the follow‐up period. In order to discriminate GCK‐MODY from MODY‐like type 2 diabetes, high‐sensitivity C‐reactive protein may be a suitable indicator in the early stage ...
Jing Liu +3 more
wiley +1 more source
[Impact of arsenic exposure on the hepatic metabolic molecular network in obese pregnant mice using metabolomics and proteomics]. [PDF]
Se Pu砷是普遍存在的环境毒物,可能影响生物体的正常生理过程。尽管已有研究探讨了砷对健康的影响,但砷暴露对肥胖孕妇肝脏代谢的影响及其作用机制尚不明确。本研究旨在通过高脂饮食诱导肥胖孕鼠模型,并采用灌胃方式模拟孕期砷暴露,以探究其对肝脏代谢的影响。孕鼠砷暴露后,我们利用代谢组学和蛋白组学技术,结合病理生化分析,对肝脏组织进行了深入研究。结果显示,砷暴露显著增加了肥胖孕鼠肝脏中的脂质累积,并伴随着炎症因子和氧化应激标志物的升高。代谢组学分析揭示了砷暴露对脂质代谢通路,特别是花生四烯酸代谢的显著影响。此外 ...
Cai LJ +6 more
europepmc +2 more sources
固相萃取-超高效液相色谱-串联质谱法同时测定动物源性食品中11种禁限兽药及代谢物
Se pu = Chinese journal of chromatography, 2021 建立了固相萃取-超高效液相色谱-串联质谱(SPE-UPLC-MS/MS)同时检测鸡蛋、液态奶、鸡肉及淡水鱼中4类(氯霉素类、硝基咪唑类、林可酰胺类与大环内酯类)8种禁限兽药与3种代谢物残留的分析方法。对样品前处理及色谱条件进行优化,样品经0.1 mol/L pH 9.0的磷酸盐缓冲液水解分散,乙腈提取,提取液经乙酸乙酯萃取后浓缩至近干,残留物用0.3 mL甲醇溶解,再加入5.7 mL磷酸盐缓冲液,混匀,溶解液经Oasis HLB固相萃取柱净化后上机分析,以甲醇与0.1%甲酸水溶液作为流动相进行梯度洗脱 ...
Bolin Liu +4 more
semanticscholar +1 more source
Isolation and Identification of Secondary Metabolites from Halophytic Helianthustuberosus Tuber-Derived Fungus [PDF]
, 2016 盐生植物菊芋(Helianthus tuberosus)是一种新型经济作物,特殊生境可能会使其内生真菌产生特殊的次生代谢产物,如结构新颖或活性显著的化合物.为研究这种耐盐植物内生真菌的次生代谢产物以及植物宿主和内生真菌之间可能存在的关系,本实验室从耐盐菊芋块茎中分离纯化出10株内生真菌,对这10株内生真菌进行抗卤虫活性筛选,初步筛选出1株抗卤虫活性良好的菌株Mucor sp.ht-7,规模发酵后通过提取分离技术得到7个化合物,用波谱手段鉴定了7个化合物的结构 ...
季乃云 +3 more
core +1 more source