Results 31 to 40 of about 12,951 (170)
Pyruvate kinase M2 inhibits cisplatin induced caspase-dependent apoptosis via ERK-mediated signaling pathway in hepatocellular carcinoma cells [PDF]
M2型丙酮酸激酶(pyruvatekinaseisoenzymetypeM2,PKM2)在肿瘤代谢 和生长等方面发挥重要作用。此外,PKM2还可作为蛋白激酶及辅助转录因子, 调控相关基因的转录表达,促进肿瘤细胞的增殖。我们实验室前期已经证实了 PKM2在肝细胞癌中高表达,并通过EGF/EGFR及TGFβ/TGFβR信号通路调控 肝癌细胞的迁移、侵袭。本课题研究目的在于进一步探索PKM2在肝癌细胞增 殖与凋亡方面的调控作用及相关分子生物学机制。 采用短发夹RNA转染HepG2和Huh7两株肝癌细胞株 ...
谌小春
core
ABSTRACT High‐power piezoelectric ceramics which have a wide operating temperature range are essential for sensor and actuator applications in extreme conditions. However, their development is fundamentally hindered by the inherent trade‐off among key parameters (TC, d33, Qm).
Rui Yan +10 more
wiley +1 more source
HREELS investigations of Oxygen absorption and oxidation of Mo(110) surface [PDF]
模型催化一直以来都是表面科学的研究热点。模型催化研究通过在单晶表面构建二 维模型催化剂,在理想条件下简化催化过程。其目的是为了研究催化反应机理,建立催 化剂结构与性能之间的微观联系,从而指导实际催化剂的合成与改进。制备规整结构的 表面氧化物膜是其中关键的一步。 通过HREELS,AES和LEED,本论文研究了Mo(110)表面与氧的相互作用,包括 氧在Mo(110)表面的吸附,Mo(110)的氧化和氧化钼膜的制备。HREELS发现在0.67ML 覆盖度下,大部分氧吸附在Mo(110)的穴位(600cm ...
徐超毅
core
ABSTRACT MCrAlX coatings are widely used as bond coats in thermal barrier coating systems to protect turbine blades from high‐temperature oxidation. However, their oxidation resistance is often restricted by uncontrolled microstructures, surface roughness, and aggregation of reactive elements (REs). In this study, high‐repetition‐rate femtosecond laser
Wei Qian +7 more
wiley +1 more source
A Green Anodic Electrolysis Strategy for Recovering Copper and Selenium From Cuprous Selenide
ABSTRACT Selenium, a rare strategic metal, is essential for advanced technologies and biological systems. Cuprous selenide (Cu2Se), a selenium‐rich compound found in copper anode slime and a promising thermoelectric material, holds great potential for recovery.
Jihua Li +7 more
wiley +1 more source
【目的】观察miR-34a在低氧诱导的大鼠肺动脉平滑肌细胞增殖中的作用并探讨其可能的机制。【方法】原代分离和培养大鼠肺动脉平滑肌细胞(PASMC),并给予3%低氧处理后,用Real-time PCR法检测miR-34a和Notch1mRNA在大鼠PASMC中的表达;低氧条件下用细胞转染法过表达和抑制miR-34a、沉默Notch1基因的表达后用EDU法观察细胞增殖情况,并用Real-time PCR和Western blot法检测细胞核增殖抗原PCNA的表达。【结果】分离和培养大鼠PASMC并给予3 ...
马兰
doaj
通过改变氧化锑的含量,分析不同含量对氧化锌电阻片电位梯度、泄漏电流等性能的影响。氧化锑在烧结过程中与氧化锌可以形成尖晶石相,可以抑制氧化锌晶粒尺寸的大小,进而调整电阻片电位梯度。在传统五元配方体系中,通过改变氧化锑的增加,电阻片收缩率逐渐增大,致密度逐渐增加;掺杂适量的氧化锑可以提高电位梯度,降低泄漏电流;掺杂过量的氧化锑会降低电位梯度。
刘亚芸, 厍海波, 杨军, 刘明新
doaj
Research on the structure and properties of SiC ceramic containing titanium and boron [PDF]
碳化硅(SiC)陶瓷具有高强度、高硬度、耐高温、抗氧化、抗化学腐蚀、低热膨胀系数、高热传导率等众多特点,不仅被广泛应用在功能陶瓷、高级耐火材料、磨料及冶金原料等民用领域,还应用于航空航天领域,用作发动机的热端部件。为了提高先驱体转化法制备碳化硅陶瓷的耐高温性和吸波性能,本文将钛、硼元素引入陶瓷先驱体中,利用二者高温下生成的二硼化钛作为SiC陶瓷的烧结助剂,提高SiC陶瓷的耐高温性能,并利用钛元素提高陶瓷的吸波性能,系统研究了钛硼的引入,陶瓷结构与性能的演变规律。 首先,固定先驱体中硼元素的含量 ...
李风萍
core
ABSTRACT NiFe‐based MIL‐55 metal‐organic frameworks (MOFs) face challenges in achieving atomically precise composition and reliable methods for uniform growth. This study addresses these challenges by applying a slow evaporation crystallization technique to crude colloidal MIL‐55 products from hydrothermal synthesis, resulting in highly uniform ...
H. R. Haris +10 more
wiley +1 more source
目的应用纳米孔长读长测序技术,深入分析正常肝实质细胞和肝癌细胞在低氧环境下的特异性转录组变化,以期阐明肿瘤细胞在低氧条件下生存与转移的内在机制,从而为肿瘤的精准靶向治疗开辟新的视角与策略。方法实验选取正常肝实质细胞系THLE-3与肝癌细胞系Hep3B作为研究对象,分别置于常氧与低氧条件下培养48 h后,提取其总RNA。随后,采用纳米孔测序技术,对这两种细胞系在不同氧浓度下的转录组进行高通量、高精度的测序分析。结果本研究成功构建了基于纳米孔三代测序技术的低氧转录本数据集,展现了前所未有的测序精度。通过GO(
高力, 沈晟齐, 高平
doaj +2 more sources

