Results 11 to 20 of about 91,305 (122)

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, EarlyView.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu, Ming Deng, Tao Ge, Li Xu, Xinnan Xu, Kaiqi Jin   +5 more
wiley   +1 more source

Comparison of two highly expressed antimicrobial peptides Scygonadin and SCY2 in Scylla paramamosain gonads and their mechanism of reproductive immunology [PDF]

, 2013
拟穴青蟹(Scyllaparamamosain，以下简称青蟹)是我国南方最重要的海水养殖蟹类品种。近些年来，随着青蟹养殖规模的不断扩大，各种病害频繁发生引起养殖青蟹大量死亡，严重影响了我国青蟹养殖业的发展。青蟹以先天性免疫为主，抗菌肽是先天性免疫系统中重要免疫因子，对抵抗病原微生物感染发挥关键作用。 Scygonadin(SCY1)和SCY2是本实验室从雄性拟穴青蟹射精管中发现的两种新抗菌肽基因，前期研究已分别阐明了两种抗菌肽的基因组成与部分特性，并证明SCY1具有生殖免疫功能 ...
乔琨
core  

Prevalence of Eight Viruses in Captive Amur Tigers (Panthera tigris altaica) From Harbin, China 中国哈尔滨市圈养东北虎8种病毒的流行

Wildlife Letters, EarlyView.
The Amur tiger, an endangered flagship species mainly found in the Russia Far East and Northeastern China, holds immense biological importance, and has been listed under the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES).
Wei Xie, Luyao Wang, Mengna Chen, Qinjie Chang, Hongyu Jiang, Haitao Xu, Liu Dan, Xiang Li, Yulong Wang, Xiangwei Zeng, Bin Yang, Miaowei Wang, Yonggang Jiang, Hongliang Chai, Siyuan Yang, Yajun Wang   +15 more
wiley   +1 more source

A Novel Topical Emollient Plus for Canine Atopic Dermatitis: A Clinical Trial Assessing Efficacy and User Acceptance

Veterinary Dermatology, EarlyView.
Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes, António Caldeira Mendes, Susana Paula Alves, Vanessa Schmidt, Ana Filipa Bizarro, Marta Pinto, Hugo Pereira, Joana Marto, Ana Mafalda Lourenço   +8 more
wiley   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, EarlyView.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

Endogenous/Exogenous Dual‐Responsive Bimetallic Hollow Nanozyme for Photothermal/Nanocatalysis/Immune Synergistic Tumor Therapy

Rare Metals, Volume 45, Issue 1, January 2026.
ABSTRACT Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency. However, they still face a major challenge from tumor metastasis. In this work, endogenous/exogenous dual‐responsive bimetallic hollow PdRu (termed HPdRu) nanozymes were prepared.
Nan‐Nan Zheng, Xin Hu, Jun‐Qing Hu
wiley   +1 more source

Developing a Linguistically Valid Japanese Version of the Chronic Pain Attribution Scale: Translation and Cultural Adaptation Process

Neuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
This study reports the development and linguistic validation of the Japanese version of the Chronic Pain Attribution Scale. The tool captures culturally nuanced beliefs about chronic pain causes and provides a foundation for research on treatment responses in Japanese‐speaking populations.
Keiko Yamada, Akihiro Yamamoto, Keita Ueno, Yukari Takahashi, Masaya Ueda, Hui Ming Khoo, Koichi Hosomi, Ryouhei Ishii, Fusao Kato   +8 more
wiley   +1 more source

The effection of everolimus on hamster-to-rat concordant heart xenotransplantation [PDF]

, 2016
背景：器官移植是解决很多终末期疾病最有效的手段，然而器官短缺限制着器官移植术的推广。异种移植是最有可能快速解决器官短缺问题的途径之一。虽然异种移植的超级性排斥反应已经因分子生物学技术的应用而极大减轻，但异种移植的急性排斥反应、延迟性排斥反应等仍旧没有克服。新型免疫抑制剂的开发可能有助于克服这些类型的免疫排斥反应。依维莫司是雷帕霉素衍生物，是一种可用于抗移植排斥的免疫抑制药物，动物实验和临床资料表明它可延长同种器官移植物生存期。依维莫司对免疫系统具有多种调节作用 ...
付嘉钊
core  

Satisfaction With Health Services During the COVID‐19 Pandemic: Results From a Population‐Based Survey in a Municipality in Southeastern Brazil

World Medical &Health Policy, Volume 17, Issue 4, Page 912-920, December 2025.
ABSTRACT In Brazil, the healthcare system is based on the provision of a public system that offers free and universal services to all citizens, supplemented by private initiative. Evaluating user satisfaction plays an important role in identifying improvements and promoting organizational changes that benefit everyone involved.
Patrícia Silva Bazoni, Francisca Janiclecia Rezende Cordeiro, Élida da Silva Timóteo, Ana Luísa Horsth, Alciellen Mendes da Silva, Ronaldo José Faria, Eduardo Frizzera Meira, Jéssica Barreto Ribeiro dos Santos, Michael Ruberson Ribeiro da Silva   +8 more
wiley   +1 more source